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Hyaluronidase (injection)

Brand names: Amphadase. Hylenex. Wydase. Vitrase. Hydase.
Injectable solution: (150 units/mL, human recombinant)
Drug class: unclassified agents

What is Hyaluronidase?

Hyaluronidase is a protein that has been genetically engineered.Injecting fluids into the body along with hyaluronidase can treat dehydration. Hyaluronidase is also used to help your body absorb other injected medicines.Hyaluronidase can also be used to make contrast dyes more visible on certain types of x-rays and scans.This medication guide does not list all uses of hyaluronidase.

Side effects of Hyaluronidase

If you experience any of the following signs and symptoms of an allergic reaction: hives, difficulty breathing, swelling of lips, face, tongue or throat - seek medical help immediately!

Hyaluronidase may cause serious side effects. If you experience:

  • You may experience swelling of your hands, feet, or other parts of the body.
  • Pain, swelling, itching or redness at the site of injection are possible side effects.

There may be other side effects.For medical advice about side effects, speak to your physician. To report side effects directly, call the FDA's help line at 1-800-FDA-1088.

Warnings

When certain drugs are combined with hyaluronidase, serious drug interactions may occur. Inform your physician of all medications you are currently taking.

Similar/related drugs

Hyaluronidase, Hylenex, Amphadase, Vitrase, and Dexrazoxane

Before you take this drug

If you have an allergy to hyaluronidase, it should be avoided.Before you take the medication, your doctor may conduct a skin test to determine if you're allergic to hyaluronidase.

Certain medicines can have unwanted or harmful effects when combined with hyaluronidase. If you use:

  • Furosemide (Lasix);
  • Dilantin (phenytoin)
  • A sedative (such as Valium, Xanax, or Ativan) or an anxiety medicine
  • Salicylates or aspirin?
  • Cortisone or ACTH (corticotropin);
  • Estrogens;
  • Antihistamines (such as cold or allergy medicines)

Inform your doctor about pregnancy.Ask your doctor if you are concerned about any risks. You should consult your doctor if you are concerned about any risks.

How to take Hyaluronidase?

Injecting hyaluronidase under the skin or into a muscular tissue, as well as into other body tissues, is the most common way to treat hyaluronidase.Healthcare providers will administer this injection.Hyaluronidase shouldn't be injected intravenously (as an intravenous injection).

What happens if I miss the dose?

You are unlikely to miss a dosage because you will be receiving hyaluronidase in a clinical environment.

What happens if I overdose?

Contact 1-800-222-1222 immediately in case of poisoning and seek immediate medical advice.

What should be avoided?

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Interaction with other drug

Other drugs, such as vitamins and herbal remedies, may also affect hyaluronidase. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using.