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Afstyla (recombinant)

Generic Name: Antihemophilic factor (recombinant) [ant-ee-hee-moe-FIL-ik-FAK-tor] Brand names: Advate, Adynovate, Afstyla, Eloctate with Fc Fusion Protein, Esperoct,… Show all 14 brands
Drug Class: Miscellaneous coagulation modifiers

What is the recombinant Afstyla?

Afstyla (clotting factor) is a natural protein that is found in blood. People suffering from hemophilia A suffer from a deficit in clotting factor VIII. Recombinant medicine substitutes the clotting factor VIII within the blood.

Recombinant Afstyla is used to treat or stop bleeding episodes in adults as well as children suffering from hemophilia A. Afstyla is often prescribed prior to a surgical procedure. Recombinant Afstyla may help stop joint damage in children who suffer from hemophilia A but have not had prior joint damage. Recombinant Afstyla is not recommended for the treatment of von Willebrand disease.

Jivi is not allowed to be used by anyone less than twelve years of age. Recombinant Afstyla can also be used to treat conditions that are not mentioned in this medication guideline.

Side Effects of Recombinant Afstyla

Seek medical attention immediately. If you notice symptoms that are warning signs of an allergic reaction, itching, hives, or numbness; tingling; nausea, dizziness, or fever; rapid pulses and chest tightness; breathing difficulties; wheezing; and pale skin. Cold sweat, feeling lightheaded, fainting, swelling of your lips, face, and throat

  • The frequency of bleeding episodes increases;
  • Any bleeding that doesn't stop;
  • Chest pain,
  • Feeling lightheaded, as if you're going to faint.

Adverse Effects.

  • Nose bleeds.
  • Nausea, vomiting, diarrhea;
  • Headache, dizziness;
  • Muscles or joint discomfort;
  • Rash;
  • Flushing (sudden heat, redness, or tingly sensation);
  • Fever, chills;
  • Cough;
  • Weakness;
  • Itching, pain, swelling, or redness in the area at the site of injection.

This isn't an exhaustive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Be sure to follow the directions for mixing and storing Afstyla. Different types of recombinant Afstyla might have different storage requirements. Your body can develop antibodies against Afstyla, which makes it less efficient. Contact your physician when this medication seems not to be effective in controlling the bleeding.

Before taking you take this drug

It is not recommended to use this medication if you've ever experienced an extreme allergy to Afstyla or are sensitive to hamster or mouse proteins. It is not recommended to use recombinant proteins if you are allergic to beef proteins. Recombinant when you are sensitive to proteins from beef.

Speak to your doctor if you are ever diagnosed with:

  • Coronary disease;
  • A lax allergy.
  • If you've ever been told that you are suffering from an inhibitor for Factor VIII.

Inform your doctor if you are breastfeeding or pregnant.

How to take Afstyla?

Your doctor will run an analysis of your blood to make sure that recombinant Afstyla is the best treatment to treat your clotting factor deficiency. Follow all instructions on your prescription label and go through all medication guides or instruction sheets. Follow the medication precisely as directed.

The doctor might modify your dosage. Always verify the potency of your medication in the prescription to make certain you are taking the right dosage. Recombinant Afstyla is administered by infusion into veins. The healthcare professional will provide your first dose and instruct you on how to make use of the drug on your own. Take note of and follow the instructions for use that come along with your medication. Recombinant Afstyla should be mixed with liquid (diluent) prior to use. Talk to your pharmacist or doctor to help you understand how to combine and preserve the medication. Make sure to wash your hands after making your injection and before giving it. Make an injection only when you are ready to administer it. Avoid using any medicine that changes color or has particles. Consult your pharmacist about new medications. Recombinant Afstyla doses are determined by weight. Your dose needs may change if you gain or lose weight. You'll need to undergo frequent medical examinations.

The body can create antibodies to Afstyla, which makes it less efficient. Contact your physician if Afstyla appears to be less effective in regulating the bleeding.B Make sure you refill your prescription before the expiration date of your medication. When you leave home, ensure that you carry enough medication and injection equipment with you. Keep unmixed recombinant Afstyla within the original container in an air-tight container in a refrigerator. Don't freeze. Take the medicine out of the refrigerator and allow it to be at room temperature prior to preparing your dosage. You can also keep unmixed recombinant Afstyla at ambient temperature, but you are not allowed to bring it into the fridge. Certain kinds of this medicine may be kept at room temperature for the specified amount of time or until the expiration date (whichever occurs first). Follow all directions on the storage of this medication. Different kinds of Afstyla that are recombinant Afstyla might come with different storage requirements.

Don't store it in direct sunlight. Do not use it after the expiration date. time limit in the packaging. After mixing the mixture and diluting agent, store the mixture at room temperature (not in the refrigerator) and make use of it after 3 hours. Every through (bottle) is intended for only one usage. It is discarded after just one use, even if there's a little medicine within. Use a needle or syringe just once, and then put them in the puncture-proof "sharps" container. Be sure to follow the laws of your state or city regarding how to dispose of the container. Make sure it is out of reach of pets and children. In the event of an emergency, wear a medical identification card to notify others that you suffer from a bleeding disorder or blood-clotting issue.

What happens if I miss a dose?

Because recombinant Afstyla is prescribed only when required, it is possible that you are not on a routine dose schedule. You may have to take the medication for a few days at a time to manage a bleeding event. Use the medicine according to instructions and notify your doctor if bleeding persists. Take any dose you missed immediately when you remember. Do not take two doses at once.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Other medications can affect the recombinant Afstyla, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor the medicines you are currently taking and any medications you begin or stop taking.