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Antihemophilic and von Willebrand factor complex

Generic name: antihemophilic and von Willebrand factor complex [AN-tye-HEE-moe-FIL-ik-and-von-WIL-e-brand-FAK-tor-KOM-plex]
Brand names: Alphanate, Humate-P, Wilate, Wilstart, Dried Factor VIII Fraction Type 8Y, Haemate P, Optivate
Formulation for dosage: intravenous powder for injection
The class of drug: miscellaneous coagulation modifiers

What is Antihemophilic and von Willebrand factor complex?

The antihemophilic factor and the von Willebrand factor are natural proteins found in blood that aid in the clotting of blood.A deficiency in the antihemophilic factor VIII is the main cause of haemophilia A. The absence of the von Willebrand factor is the main cause of the condition known as von Willebrand disease. Antihemophilic and von Willebrand factors complex functions by temporarily increasing levels of factor VIII, also known as von Willebrand factors, in blood to assist in the process of clotting.Antihemophilic and Von Willebrand factor complex is a combination medication that is used to treat or prevent bleeding events in people suffering from von Willebrand disease.Antihemophilic and Von Willebrand factor complexes can also be used to prevent or treat bleeding episodes in people suffering from haemophilia A.Antihemophilic, as well as the Willebrand factor complex, may be used to treat conditions that are not mentioned in this guideline.

Side  effects of Antihemophilic and von Willebrand factor complex

Take immediate medical assistance in the event that you exhibit symptoms that indicate an allergic reaction, such as chest tightness, hives, wheezing, difficulty breathing, feeling like you're going to faint or pass out, or swelling of your lips, face, tongue, throat, or face.

Antihemophilic and the von Willebrand factor complex can result in serious adverse negative side effects. Should You Experience: If You experience:

  • Hot flashes when an injection is provided;
  • Sudden weakness or numbness (especially on the opposite or both sides of the body) or slurred speech. Difficulties with balance or vision;
  • A sudden cough and bloody cough
  • The sensation of warmth, pain, swelling, or redness on either or both legs;
  • Yellowed or pale skin; dark-coloured urine; the feeling of fever and weakness;
  • Bleeding from a wound or an area where it was the case that medicine had been injected
  • Bleeding that isn't controlled.

Common adverse effects of the antihemophilic and von Willebrand factor complexes could be:

  • Nosebleeds;
  • Itching (or scratching;
  • Tingling or numbness
  • Headache, dizziness,
  • Lower back pain.

This list does not represent all possible side effects. Other side effects could occur. Consult your physician to seek medical advice on the effects. Report any adverse reactions directly to the FDA at 1-800-FDA-1088.


It is not recommended to use this medication if you've suffered an extreme allergic reaction to antihemophilic factors before.The body could develop antibodies against antihemophilic factor, which makes it less efficient. Contact your physician if you are antihemophilic and the Willebrand factor complex appears to not be as effective in regulating the bleeding.Follow all directions regarding how to store this medication. Each brand of antihemophilic as well as the Willebrand factor complex could contain specific storage guidelines.

Before you take this drug

It is not recommended to use this medication if you've experienced a severe reaction to antihemophilic factors.To ensure that you are able to safely take this medication, consult your physician in the event that you've had a stroke or blood clot.Your physician may ask you to get a hepatitis vaccine prior to when you begin using antihemophilics or the Willebrand factor complex.It isn't known if this medication could affect a newborn baby. Inform your doctor if you are expecting or planning to be pregnant.It isn't known if antihemophilic and the von Willebrand factor complex are absorbed into breast milk or if they can harm the nursing infant. Consult a physician if breastfeeding your infant child.The antihemophilic and von Wilhelm factor complexes are derived by consuming human plasma (parts of the blood), which could be contaminated with viruses and other infectious agents. Plasma donated is analysed and treated to decrease the chance of it being contaminated by infectious agents; however, there is a slight possibility that it can transmit the disease. Discuss with your physician the potential risks and benefits of this treatment.

How to take Antihemophilic and von Willebrand factor complex?

Follow the instructions on the prescription label. Don't use antihemophilic or Von Willebrand Factor Complex in greater or less quantities or for longer duration than is recommended. Always verify the dose of medication in the package to make sure that you are taking the right dose.Antihemophilic and Willebrand factor complexes can be injected into veins via an IV. You might be shown how to inject an IV at home. Don't give yourself this medication if you do not know how to apply the injection properly and get rid of the IV tubing, needles, and other equipment employed.Take note of all information for patients, including medication guides and instructions sheets that you receive. Talk to your pharmacist or doctor for assistance if you have concerns.Make sure to wash your hands prior to making your injection and before giving it.Antihemophilic and von Willebrand complex is a medicine in powder form that needs to be mixed with liquid (diluent) prior to use. If you're taking injectables yourself, make certain you know how to blend and keep the medication.After mixing the medication with a diluting agent, keep it at room temperature and take it out after 3 hours. Don't refrigerate or freeze it.Don't shake or stir the mixture of medicine. Make sure to prepare your dose using the syringe when it is time to inject yourself. A single-use vial can be used for only one purpose. After you've measured your dosage, you can throw the container away, regardless of whether there's still medicine inside it.

Do not take an antihemophilic or von Willebrand factor compound if it's changed colour or contains particles within it. Contact your pharmacist to inquire about a new medication.Make use of the disposable needle and syringe just once. Make sure you follow any state or local regulations on disposing of needles and syringes that are no longer in use. Make sure you use a puncture-proof "sharps" disposal container (ask your pharmacist where you can get one and what to do with the container). Make sure this container is away from pets and children.When you are taking this medication, it is possible that you will require frequent blood tests.Your body can develop antibodies against antihemophilic factor, and this can make it less efficient. Contact your physician should this medication appear to be less effective in reducing the bleeding.Follow all directions on how to store this medication. Every brand of antihemophilic and of Willebrand factor complex could have storage instructions specific to the brand.Keep the diluent and medicine within the room at room temperature and away from heat and moisture. Get rid of any medicine not utilised prior to the deadline for expiration on the label of the medicine.It is recommended that the Wilate brand of this medication be kept inside the container that it came in within the refrigerator. Don't freeze. Before preparing your dosage, you should take these items out of the refrigerator and let them reach room temperature.If you keep this medication at ambient temperature, do not take it out of the refrigerator.Wear a medical alert tag or have an ID card that states that you suffer from haemophilia or Willebrand disease. Any medical professional who sees you should be aware that you suffer from an underlying blood-clotting or bleeding disorder.

What happens if I miss the dose?

Since this medicine is usually utilised only for emergencies, it is possible that you are not on a schedule for dosing. If you're following a routine, you should take the missed dose as quickly as you can remember. Do not take your missed dosage if you are nearing the time for the next dose scheduled. Do not attempt to compensate by taking additional medication than what was missed.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.

Interaction with other drug

Other medications can interact with antihemophilic as well as the Willebrand factor complexes, which include medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your health professionals about any medications you are taking currently and all medicines that you decide to stop or modify your use of.