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Name of the Generic: Anagrelide an-AH-gre-lide an-AH-gre-lide [an-AH-gree-lide]
Classification of Drugs: Miscellaneous coagulation modifiers

What is Agrylin?

Agrylin is a treatment for the blood cell disorder known as thrombocythemia (also known as thrombocytosis) that occurs in the body when it produces excessive platelet cells. Agrylin can also be used for reasons not mentioned in this guideline.

Side Effects of Agrylin

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, and tongue,

Adverse reactions of Agrylin:

  • Bleeding or easy bruising (nosebleeds and bleeding gums);

  • Symptoms of stomach bleeding: bloody or black stools, the spouting of blood, or vomiting that appears like coffee grounds.

  • Chest pain, pressure, or achymus;

  • Heartbeats that are fast or rapid, the chest fluttering, and suddenly feeling dizzy (like you're about to pass out);

  • Breathlessness;

  • Swelling in your lower legs;

  • Blue-colored lip or the skin.

Negative side effects of Agrylin:

  • Rapid heartbeats as well as chest pain and breathing difficulties;

  • Numbness, tingling, or burning pain;

  • Headache, weakness, and dizziness;

  • Stomach discomfort, gas, and indigestion, as well as a lack of appetite;

  • Nausea, vomiting, diarrhea;

  • Swelling of your feet or hands;

  • High fever, cough, and not feeling well.

  • Lower back pain

  • Rash, itching.

This is not a complete list of all the side effects. Other side effects could occur. Contact your doctor to seek medical advice on adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


Follow the directions on your prescription label and the package. Inform your health care providers about your medical issues, allergies, and any other medications you take.

Before you take this drug

Inform your doctor if you have ever suffered from:

  • Bleeding issues;

  • Long QT syndrome (in either you or a member of your family);

  • Issues with the lung or heart;

  • The liver condition or

  • An electrical imbalance (such as a low level of potassium in your blood).

It isn't known if agrylin could harm a newborn baby. Consult your physician if you are pregnant or planning to be pregnant. This medication can affect fertility (your capacity to bear children). It is not recommended to breastfeed when you are using Agrylin. Agrylin isn't approved for use by anyone less than 7 years old.

How to take Agrylin?

Your heart's function could need to be monitored by using an electrocardiograph, or ECG (sometimes known as an EKG), prior to or during your treatment. It is also possible that you will require frequent blood tests while taking Agrylin. Follow the directions on the prescription label and read the medication guide or instructions sheets. The doctor might alter the dosage. Make sure you take the medicine precisely as directed.

If you are in need of surgery, inform the surgeon beforehand that you're using Agrylin. Maintain at room temperature, free of heat, moisture, and light.

What happens if I miss a dose?

Do not take the medicine for as long as you are able, but avoid any missed doses if you are close to the time of the next dose. Don't take two doses at once.

What happens when I Overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Take aspirin only unless your doctor has advised you not to. Follow your doctor's instructions regarding the dosage of aspirin to take and how often you should take it.

Consult a physician or pharmacist prior to using any medication for fever, pain, swelling, symptoms of

a cold, or influenza symptoms. They may contain aspirin or similar components (such as ibuprofen, ketoprofen, and naproxen), which may increase the chances of bleeding.

Interaction with other drugs

Agrylin may cause serious heart issues. The risk is greater if you are also taking different medicines to treat asthma, infections, heart conditions, high blood pressure, mental illness, depression, malaria, cancer, or HIV.

Inform your doctor about any other medications you take, particularly:

  • An antidepressant

  • Medication to increase blood flow

  • A bleeding thinner (such as warfarin or Coumadin) or a different medication to prevent or treat blood clots

  • These are NSAIDs (nonsteroidal anti-inflammatory drugs): aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and many more.

This list isn't complete. Other medications may interact with Agrylin, such as medications that are prescribed and available over the counter, vitamins, and herbal supplements. Some interactions with drugs are not listed here. are listed here.



Prescription only

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