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Generic Name: Pancreatin [PAN-kree-a-tin]
Names of Brands: Hi-Vegi-Lip, Pancreatin 4X, Donnazyme Digi Pepsin
Dosage Format: Oral tablet (-)
Drug Class: Digestive enzymes

What is Pancreatin?

Pancreatin is a mixture of digestive enzymes (proteins). These enzymes are made by the pancreas and are vital for digesting proteins, fats, and sugars.

Pancreatin is a replacement for digestive enzymes in cases where the body is not able to produce adequate amounts of these enzymes. Certain medical conditions can trigger this deficiency of enzymes, for example, cystic fibrosis, pancreatitis, pancreatic cancer, and pancreas operations.

Pancreatin is also utilized to manage a problem known as steatorrhea (loose and fatty stools).Pancreatin is also used for reasons not mentioned in this guideline for medication.

Side effects of Pancreatin

See a doctor immediately. If you experience any of the following symptoms that indicate an allergic reaction, difficulty breathing or swelling of your lips, face, or tongue.

Pancreatin can cause severe adverse effects. Consult your physician right away in the event that you experience:

  • Severe nausea, vomiting, or diarrhea;
  • Severe stomach pain;
  • Joint pain, swelling,
  • Any modifications in your health.

Common adverse effects of pancreatin could include:

  • Nausea, mild stomach pain;
  • Diarrhea;
  • Mild skin rash.

This isn't a complete list of all the side effects. Other side effects could occur. Contact your physician for advice regarding medical effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Pancreatin is not a good option if you are allergic to pork proteins or if you suffer from an abrupt onset of pancreatitis or the escalation of a longer-term issue within the pancreas.

Before you take this drug

It is not recommended to take pancreatin if you are allergic to pork proteins or if you suffer from acute pancreatitis or the deterioration of a problem that has been lingering for a long time in the pancreas.

To ensure that pancreatin is safe for you, ask your doctor if you have:

  • Gout;
  • Asthma
  • Any allergies.

FDA classification for pregnancy C It isn't known whether pancreatin can cause harm to an unborn baby. Don't take pancreatin unless you have a physician's recommendation when you are pregnant.

It is unclear if pancreatin is absorbed into breast milk or if it can harm the baby who is nursing. Do not take this medication without seeking a doctor's guidance if you breastfeed babies.

How to take Pancreatin?

Take it exactly as stated on the label or as directed by your physician. Your doctor might alter the dosage to ensure that you receive the most effective outcomes. Don't use in greater quantities, in smaller amounts, or for longer periods than prescribed.

Pancreatin is best taken in conjunction with a meal or a snack.Consume pancreatin along with a large cup of water.Don't keep tablets in the mouth. The medicine could cause irritation in the mouth's interior.Don't crush, chew, or break a tablet of pancreatin. Take it in whole.

To ensure that this medication will help your condition, it is possible that you will require regular blood tests. You might not notice any changes in your symptoms, but your blood test results will assist your doctor in determining the length of time you will be treated with pancreatin.Consult your doctor if symptoms do not improve or if they become worse when you use pancreatin.

Pancreatin could be a component of a comprehensive treatment that also includes a diet plan. Follow the diet plan developed by your physician or nutritionist. Be familiar with the list of food items you should avoid eating to control your illness.

Utilize pancreatin frequently to get the greatest benefits. Refill your prescription prior to the time you're out of medicine completely. It is possible that you will need this medication for the rest of your life.Place it in a cool, dry place far from heat and moisture.

If your doctor has changed the strength, brand, or type of pancreatin you receive, your requirements for dosage may alter. Consult your pharmacist if you have any concerns about the brand new type of pancreatin available at the pharmacy.

What happens If I miss a dose?

You should take the missed dose as quickly as you can remember. Avoid any missed doses if you are nearing the time for the next dose. Do not take any additional medicine to make up for the missed dose.Always take pancreatin when eating.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

What should be avoided?

Do not use or take any digestive enzymes unless your doctor advises you to.Do not take an antacid for more than 1 hour prior to or after taking pancreatin.

Interaction with other drugs

Other medications can interfere with pancreatin, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Be sure to inform your health professionals about any medications you take currently and any medicines you stop or start using.