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Genric Name: estradiol oral (also known as ess-traDYE-ole “ess-tra-DYE”
Names of brands: Estrace, Femtrace, Gynodiol
Drug class: estrogens

There is no evidence that the Femtrace brand name was taken off the market in the U.S. If the generic versions of this product are approved by the FDA, There may be alternatives that are generic.

What is Femtrace?

Femtrace is one of the forms of estrogen, which is a female sex hormone that is produced by the ovaries. Estrogen is required for numerous processes within the body.

Femtrace is a treatment for menopausal symptoms such as hot flashes, vaginal dryness, burning, and irritation. Other applications include preventing osteoporosis in women who are postmenopausal and replacing estrogen for women who suffer from ovarian failure or other medical conditions that lead to an absence of estrogen naturally within the body. Femtrace can be used in conjunction with cancer treatment for both men and women.

Femtrace is also used for different purposes that aren't mentioned in this guideline.


Femtrace may harm a newborn baby or result in a birth defect. Don't use Femtrace when you are expecting. It is not recommended to take Femtrace in the event of abnormal vaginal bleeding or liver disease such as breast or uterine cancers, hormone-dependent cancers, or a history of a heart attack, stroke, or stroke if you're pregnant, have experienced an occurrence of a blood clot (especially in your lungs or lower body), or are allergic to any medicine or food coloring. The use of hormones may increase the chances of developing stroke, blood clots, and heart attacks, particularly in those with diabetes or high blood pressure, excessive cholesterol or triglyceride smoking, or who are overweight.

In the long run, Femtrace treatment could increase your risk of developing breast cancer, ovarian cancer, and uterine cancer. Discuss with your physician your specific risks prior to taking Femtrace for long-term use. Your doctor should review your performance every 3 to 6 months to determine if you need to continue the treatment.

If you are taking progesterone during the use of Femtrace, it can reduce your chances of getting uterine cancer. If your uterus hasn't yet been eliminated, your physician might prescribe a progestin for you to use while you're taking Femtrace.

Femtrace is not recommended to treat heart disease, stroke, or dementia because the medication could increase the risk of developing these diseases.

Make sure you have regular physical examinations and mammograms. You can also examine any lumps in your breasts on a regular basis using femtrace.

Prior to use this drug

Femtrace is not recommended in the event that you are allergic to estradiol or suffer from:

  • Liver disease;
  • Abnormal vaginal bleeding, which the doctor hasn't checked;
  • Any kind of cancer of the uterus, breast, or hormone-dependent cancers;
  • A recent history of stroke or heart attack;
  • If you are pregnant,
  • If you've ever experienced a clot in your blood (especially in your lung or lower body) or
  • If you're allergic to certain medicines or food dyes,

Intake of hormones can increase the risk of blood clots, stroke, or heart attack, particularly if you are prone to high-risk factors like diabetes, high blood pressure, excessive cholesterol or triglycerides, smoking cigarettes, or are overweight.

To ensure that you are able to safely use femtrace, consult your physician if you suffer from any of these ailments:

  • Heart disease;
  • Kidney disease
  • Family background of blood clots
  • An occurrence of jaundice that was caused by hormonal changes or due to pregnancy;
  • Endometriosis;
  • Lupus;
  • Porphyria;
  • Gallbladder disease
  • Underactive thyroid gland;
  • Asthma;
  • Epilepsy or another seizure disorder;
  • Migraines;
  • Low levels of calcium in your blood.
  • If you've taken your uterus out (hysterectomy),

FDA classification for pregnancy: "XFemtrace can harm an unborn baby or cause birth defects. Avoid using Femtrace in the event that you are expecting. Contact your physician immediately in case you fall pregnant while receiving treatment. Femtrace may be passed in breast milk and harm a nursing child. It can also reduce the production of breast milk. Breastfeeding is not advised when you take Femtrace. Estradiol shouldn't be used to treat stroke, heart disease, or dementia, as Femtrace can increase the risk of developing these ailments.

How to take Femtrace?

You should take Femtrace exactly as prescribed to you. Don't use the drug in greater amounts or for a longer period than the time recommended by your physician.

The long-term Femtrace treatment could increase the risk of breast cancer, ovarian cancer, and uterine cancer. Consult your doctor about the risks specific to you prior to making use of Femtrace for long-term use.

Utilizing progestin when using Femtrace can reduce the chance of developing uterine cancer. If your uterus hasn't had it removed yet, your physician may recommend a progestin for you to use while you're taking Femtrace.

Make sure you have regular physical exams and mammograms. You should also check the breasts to detect lumps every month during the use of Femtrace. Your doctor should review your improvement at intervals of three to six months to decide whether or not you need to continue the treatment.

If you require surgical or medical tests or are being placed on bedrest, it is possible to discontinue using this drug for a brief period of time. Any surgeon or doctor who cares for you must know that you're taking Femtrace.

Keep Femtrace in a cool, dry place free of heat, moisture, and light.

What happens if I miss the dose?

You should take the dose you missed as quickly as you remember. Avoid any missed doses if you are nearing the time for the next dose. Do not take any additional medicine to make up for the missed dose.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

The effects of an overdose could result in nausea, vomiting, and vaginal bleeding.

What should be avoided?

Do not smoke when using Femtrace. Smoking cigarettes can increase the chances of having blood clots, strokes, and heart attacks caused by estrogen.

Side effects of Femtrace

Contact a medical professional immediately in the event that you exhibit any of the following symptoms: warnings of an allergic reaction, such as hives; difficulty breathing; and swelling of your lips, face, and tongue. Stop taking Femtrace and contact your physician immediately if you notice an adverse reaction that is serious, like:

  • Abnormal vaginal bleeding (especially in the case of the menopausal stage);
  • Chest pain or feeling heavy in the chest; pain spreading into the shoulder or arm; nausea; sweating; general feeling of discomfort;
  • The sensation of weakness or numbness suddenly in one area of the body.
  • Suddenly severe headache, confusion, or problems in speech, vision, or balance
  • Stabbing chest pain, a sudden cough, wheezing, rapid breathing, and rapid heart rate
  • Discomfort, swelling, or redness on either or both legs;
  • Nausea nausea, vomiting, lack of appetite, thirst, weak muscles, confusion, and a feeling of being tired or uneasy;
  • A lump on your breast
  • Feeling like you might pass out;
  • Discomfort, swelling, or tenderness in your stomach;
  • Jaundice (yellowing of the eyes or skin)

Not as grave Femtrace adverse effects could include:

  • Mild nausea, vomiting, bloating, and stomach cramps;
  • Tenderness, pain in the breasts, or swelling;
  • Freckles, or darkening of facial skin
  • Loss of hair on the scalp
  • Discharge or vaginal itching or discharge from the vagina;
  • Menstrual changes or breakthrough bleeding

This isn't an exhaustive list of possible side effects, and others could happen. Consult your physician to seek medical advice on the effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Inform your physician about any other medications you take, particularly:

  • A blood thinner, such as warfarin (Coumadin);
  • cimetidine (Tagamet);
  • carbamazepine (Carbatrol, Tegretol);
  • phenobarbital (Luminal, Solfoton);
  • Phenytoin (Dilantin);
  • rifampin (Rifadin, Rifater, Rifamate, Rimactane); or
  • Ritonavir (Norvir);
  • John's Wort;
  • An antibiotic like clarithromycin (Biaxin) or the antibiotic erythromycin (E-Mycin, E.E.S., Erythrocin, and Ery-Tab)
  • antifungal medicine like ketoconazole (Extina, Ketozole, Nizoral, and Xolegal).

This list isn't exhaustive, and other medications may be incompatible with Femtrace. Inform your doctor about the medications you are taking. This includes prescriptions, over-the-counter vitamins, herbal products, and vitamin products. Don't begin an entirely new drug without consulting your physician.




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