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Antihemophilic factor (recombinant)

Generic name: antihemophilic factor (recombinant) [ant-ee-hee-moe-FIL-ik-FAK-tor]
Brand names: Advate, Adynovate, Afstyla, Eloctate with Fc Fusion Protein, Esperoct,… Show all 14 brands
Forms of dosage: intravenous kit (recombinant albumin-free) intravenous powder to be used to inject (aucl Recombinant PEGylated; Exei, the recombinant glycopegylated form; porcine; Recombinant; Recombinant albumin-free; Fc fusion protein that is recombinant; Recombinant PEGylated)
The class of drug: miscellaneous coagulation modifiers

What is Antihemophilic factor (recombinant)?

Antihemophilic factors (clotting factors) are naturally occurring proteins found in blood. People suffering from haemophilia A are deficient in the clotting factor VIII. Recombinant antihemophilic factors replace clotting factor VIII in blood.Recombinant antihemophilic factor is used to prevent or treat bleeding in adults as well as children suffering from haemophilia A. The antihemophilic factor may be administered prior to a surgical procedure.Recombinant antihemophilic factors can prevent joint injuries in children with haemophilia A with no previous joint damage.Recombinant antihemophilic factor should not be used in the treatment of von Willebrand disease.Jivi is not a valid format for anyone under 12 years of age.Recombinant antihemophilic factors can also be used for other purposes that are not mentioned in this guideline.

Side effects of Antihemophilic factor (recombinant)

Seek medical attention immediately. If you notice symptoms or warning signs of an allergic reaction, itching, hives and tingling, numbness; nausea, dizziness, or fever; rapid beats in your heart; tightening of the chest; wheezing; difficulty breathing; pale skin; cold sweat; feeling lightheaded and faint; and swelling of your lips, face, or tongue.

Antihemophilic factors may cause serious side effects. Contact your physician immediately in the event of:

  • More frequent bleeding episodes;
  • Any bleeding that does not stop;
  • Chest pain;
  • Sensations of lightheadedness; feeling as though one could faint.

Common adverse reactions to antihemophilic factors could include:

  • Nose bleeds;
  • Nausea, vomiting, diarrhoea;
  • Headache, dizziness;
  • Muscles or joint discomfort;
  • Rash;
  • Flushing (sudden heat, redness, or a tingly sensation);
  • Fever, chills;
  • Cough;
  • Weak
  • Itching, pain, swelling, or redness at the site after the injection

These side effects may not be all-inclusive and others could also occur.Consult your physician to seek medical advice on the effects.Report all adverse reactions directly to the FDA at 1-800-FDA-1088.

Similar/related drugs

Traexamic acid, desmopressin, DDAVP, Cyklokapron, antihemophilic factor, and Roctavian


Be sure to follow the instructions on mixing and storing antihemophilic factors. Different types of recombinant antihemophilic factors may come with different storage instructions.Your body could develop antibodies against antihemophilic factor, and this can make it less efficient. Contact your doctor when this medication appears to not be effective in reducing the bleeding.

Before you take this drug

Do not take this medication if you have suffered an extremely allergic reaction to the antihemophilic factor or if you're allergic to hamster or mouse proteins. It is not recommended to use Recombinate if you are allergic to any of the brands. Recombinate when you are sensitive to beef proteins.

Inform your doctor if you were ever diagnosed with:

  • Coronary disease;
  • A lax allergy
  • If you've ever been told that you are suffering from an inhibitor for factor viii,

Inform your doctor if you are nursing or pregnant.

How to take Antihemophilic factor (recombinant)?

The doctor will conduct tests on your blood to be sure that recombinant hemophilic factor is the correct treatment for your deficiency in clotting factors.Follow the instructions on your prescription label, and go through all medication guides or instructions sheets. Follow the medication exactly as prescribed.The doctor might alter your dosage. Always be sure to check for the potency of your medication in the prescription to make certain you are taking the correct dosage.Recombinant antihemophilic factor is administered as an injection into the vein. Your healthcare professional will administer the first dose and guide you on how to make use of the medication on your own.Take note of and follow the instructions for use that are included in your medication. Recombinant antihemophilic factors must be mixed with liquid (diluent) prior to use. Consult your physician or pharmacist for help if you aren't sure how to combine and preserve the drug.Wash your hands thoroughly prior to taking your injections and preparing them.Make an injection only if you are able to administer it. Don't use any medicine that has changed colour or contains particles. Consult your pharmacist about the latest medication.Doses of recombinant antihemophilic factors are determined by weight. Your dose needs may alter if you gain or lose weight, as your dosage requirements could alter accordingly.You'll need to take regular medical tests.

Your body could develop antibodies against antihemophilic factor, and this can make it less efficient. Consult your physician when antihemophilic factor is found to not be as effective in controlling the bleeding.Make sure you refill your prescription before the expiration date of your medication. If you are away from home, ensure that you've got enough medicine and injectors to take with you.Recombinant antihemophilic factor that is not mixed with the original packaging in an airtight container in a refrigerator Don't freeze. Take the medicine out of the refrigerator and allow it to be at room temperature prior to preparing your dosage.You can also store recombinant antihemophilic factors that are not mixed in a cool, dry place; however, you are not allowed to take them back to your refrigerator. Certain types of this medicine may be kept at room temperature for the specified amount of time or until the expiration date (whichever is earlier).Follow all directions on how to store the medicine. Different types of recombinant antihemophilic factors may have different storage requirements.Avoid storage in bright sunlight. Do not consume it after its expiration date has passed.time limit printed on the package.After mixing the medicine with the diluting agent, store the mixture at room temperature (not in the refrigerator) and make use of it after 3 hours.Every throughl (bottle) is intended for only one usage. It is discarded after one use, regardless of whether there is medicine in the bottle.Make use of a needle and syringe just once, and then put them into a puncture-proof "sharps" container. Be sure to follow the laws of your state or city on how to dispose of the container. Keep it away from pets and children to prevent accidental ingestion or spills.In the event of an emergency, be sure to wear a medical identification card to inform others that you are suffering from a bleeding disorder or a blood clotting issue.

What happens if I miss the dose?

Since recombinant antihemophilic factors are utilised when they are needed, it is possible that you are not on a regular dose schedule. You may have to take the medication for a few days consecutively to manage a bleeding event. Continue to use the medication according to instructions and notify your doctor if bleeding persists.Take any dose missed within a few minutes of remembering. Do not take two doses at the same time.

What happens if I overdose?

For medical emergencies, immediately seek emergency care or contact the Poison Help Line at 1-800-222-1222 for support.

What should be avoided?

Follow the instructions of your physician regarding restrictions on drinks, food, or activities.

Interaction with other drug

Other drugs can impact the recombinant factor for antihemophilic, which includes prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about the medicines you are currently taking and any medication you begin or stop taking.