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Indapamide (in-DAP-a-mide)
Brand name:Lozol
Oral tablet (1.25%; 2.5%)
Drug class: thiazide diuretics

What is Indapamide?

Indapamide (also known as a water pill) is a thiazide that prevents your body from absorbing excessive salt. This can lead to fluid accumulation.

Indapamide is used to treat fluid retention (edema)  in patients with congestive heart failure. Indapamide can also be used to treat hypertension.  Indapamide can be used in other ways not mentioned in this guide.

Side effects of Indapamide

Seek immediate medical care if you have any of these symptoms: difficulty breathing, swelling in your face, lips, throat, or tongue.

If you notice any of the following signs, call your doctor immediately.

  • Tiredness, fatigue, feeling drowsy;
  • Leg cramps, muscle weakness, or a limp feeling
  • Feeling unsteady, severe weakness, and loss of coordination;
  • Feeling restless, feeling fluttering, or having fast heartbeats
  • Numbness or tingling
  • Vomiting, constipation;
  • Headache confusion, slurred words;
  • Feeling lightheaded, like you might pass out.
  • Increased thirst;
  • Little or no urinating.

Indapamide can cause a number of side effects.

  • Dizziness;
  • Weakness, tiredness;
  • Muscle cramps;
  • Feeling anxious or agitated
  • Headache
  • Runny nose

There may be other side effects. Call your doctor for medical advice about side effects. To report adverse effects, you can contact the FDA at 1-800-FDA-1088.

Similar/related drugs

Amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide, and spironolactone


Indapamide should not be used if you have an allergy to Sulfa drugs or if your urination is impaired.

Before you take this drug

Indapamide should not be used if you have an allergy to it or if

  • You are unable to urinate
  • You are allergic to sulfa medications.

Tell your doctor about any of the following to ensure that indapamide will be safe for you:

  • Cirrhosis, or other liver diseases.
  • Kidney disease
  • Low levels of potassium or sodium
  • Gout;
  • Diabetes;
  • Lupus;
  • If you're on a diet low in salt,

It is unlikely that indapamide will harm an unborn child.Tell your doctor immediately if you plan to get pregnant.

Indapamide does not pass into breast milk. It is also unknown if it can harm a baby who is nursing. This medicine should not be taken while breastfeeding.Indapamide should not be used by anyone under the age of 18.

How to take Indapamide?

Please follow all the instructions on the prescription label. Your doctor may change your dosage from time to time in order to get you the best results. Use indapamide only at the recommended dose. Do not exceed it.Indapamide should be taken in the morning. Don't forget to listen to your doctor.If you experience persistent nausea or diarrhea or are experiencing more sweating than normal, call your doctor. This medicine can cause you to become dehydrated, leading to low pressure and a serious electrolyte imbalance.You may require frequent blood pressure and medical tests while using indapamide. If you are vomiting or dehydrated, your blood and urine will be tested.

Even if you're feeling well, continue to take this medication if you have high blood pressure. Often, high blood pressure has no symptoms. Blood pressure medication may be needed for the rest of your life.Store away from heat, moisture, and light. When not in use, keep the bottle tightly shut.

Details on dosage

Adult dose for oedema:

Initial dose: oral, 2.5 mg once daily.

Usual Adult Dose for Hypertension:

Initial dose: oral, 1.25 mg once daily.

What happens if I miss the dose?

Take the missed dose as soon you remember. Skip the missed dosage if your next dose is scheduled soon. Do not increase your dose to make up for the missed one.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.Overdose symptoms include nausea, vomiting, dizziness, and thirst.

What should be avoided?

Drink enough fluids to avoid becoming dehydrated or overheated during exercise or in hot weather. You should follow your doctor's advice on the amount and type of fluids to drink. Drinking too much liquid is as dangerous as not drinking enough.

Interaction with other drug

Tell your doctor if you are taking any new medications or if you will stop taking any of your current ones.

  • Digoxin, digitalis;
  • Lithium;
  • Blood pressure medication
  • Steroids (prednisone and others)

This list is incomplete. Indapamide may interact with other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. The drug guide doesn't list every possible interaction.



Prescription only

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