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Antihemophilic factor (human)

Generic name: antihemophilic factor (human) [an-tee-hee-moe-FIL-ik-FAK-tor]
Brand names: Hemofil-M, Koate-DVI, Monoclate-P
Dosage format: intravenous powder for injection (human)
Classification of drugs: Miscellaneous coagulation modifiers

What is Antihemophilic factor (human)?

The antihemophilic factor (also known as ADD) is a natural protein that is found in blood and assists blood in clotting. The absence of antihemophilic factor VIII is the reason for haemophilia A. Human antihemophilic factors work by temporarily increasing levels of factor VIII in the blood to assist in clotting.Human antihemophilic factors are used to prevent or treat bleeding events in people suffering from haemophilia A. It can also be used to stop bleeding from surgeries or dental procedures for those suffering from haemophilia.Human antihemophilic factors are not to be used in patients suffering from von Willebrand disease.Human antihemophilic factor can also be used to treat conditions that are not mentioned in this guideline for medication.

Side effects of Antihemophilic factor (human)

Seek medical attention immediately. If you exhibit symptoms that indicate an allergic reaction, such as hives, tension in your chest, wheezing, trouble breathing, feeling lightheaded, fainting, or swelling of your lips, face, and tongue,

Human antihemophilic factors can cause serious adverse side effects. Stop using human antihemophilic factors and consult your physician immediately if you experience:

  • Feeling the tingling sensation in your face, ears, or arms
  • Headache, blurred vision, feeling jittery
  • Fever, colds, tiredness, and a runny nose that is and drowsiness, followed by a skin eruption along with joint discomfort 2 weeks later;
  • Nausea, vomiting nausea, stomach pain nausea, vomiting, loss of appetite urine, stools that are clay-colored, and  jaundice (yellowing of the eyes or skin).

Common side effects of antihemophilic factors could include:

  • Swelling, itching, or irritation in the area where the injection was administered.
  • Chills;
  • Mild nausea, slight nausea
  • An allergic reaction.

This isn't a complete list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on the effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


Do not take antihemophilic factors if you've experienced a severe allergy to the antihemophilic factors previously.Your body could create antibodies to antihemophilic factors, and this can make it less efficient. Contact your doctor when this medication appears to not be as effective in controlling the bleeding.Be sure to follow the instructions regarding how to store this medication. Each brand of human antihemophilic factor could include specific instructions for conserving the medication in an airtight container or at room temperature and only for a specific quantity of months.

Before you take this drug

This medication is recommended if you've ever suffered a severe reaction to antihemophilic factors or if you're allergic to the mouse protein.Before you can use human antihemophilic factor, the specific blood clotting disorder needs to be diagnosed as a factor VIII deficiency. Human antihemophilic factors cannot treat von Willebrand disease.Your physician may ask you to get a hepatitis vaccine prior to when you begin using humans with antihemophilic factors.It is unclear if this medication could affect a newborn baby. Inform your doctor if you are expecting or planning to be pregnant.It isn't known if the human antihemophilic factor is absorbed into the milk of a nursing mother or the extent to which it may affect a nursing child. Inform your physician immediately if you plan to breastfeed your infant.Certain types of human antihemophilic factors are not permitted for use by those who are younger than 18. Contact your doctor for any queries about the specific brands used in this drug.Human antihemophilic factors are made from plasma from humans (part from the blood) that could contain viruses and other infectious agents. Plasma donated to the clinic is analysed and treated to decrease the chance of it being contaminated by infectious agents; however, there's a chance that it could still carry the possibility that it may transmit the disease. Discuss with your physician the dangers and benefits of this drug.

How to take Antihemophilic factor (human)?

Follow the directions on the prescription label. Don't use antihemophilic factor in greater or lesser quantities or for longer than the recommended time. Always confirm your dose of medication in the prescription to make certain that you're using the correct dosage.Human antihemophilic factors are injected into a vein by way of an IV. It is possible to be taught how to administer an IV at home. Do not inject yourself with this medication if you do not know how to apply the injection correctly, and eliminate IV tubing, needles, and other equipment employed.Check all the information about your patient, including the medication guides and instructions provided to you. Talk to your pharmacist or doctor for assistance if you have concerns.Wash your hands thoroughly after making your injection and before giving it.Human antihemophilic factor is a powder medicine that has to be mixed with liquid (diluent) prior to use. If you're taking injectables yourself, make certain you know how to blend and keep the medication.After mixing the medicine with diluent, make sure to keep your mixture in a cool place until you are ready to make use of it within 3 hours. Don't put the mixture in the refrigerator.Prepare your dose using the syringe, and when you're ready, administer an injection. A single-use syringe is designed for one-time use only. After you have measured your dose, discard the vial, regardless of whether there's medicine in it.Don't use the human antihemophilic factor if it's changed colour or contains particles within it. Consult your pharmacist about the latest medication.Utilise the disposable needle and syringe just once. Be sure to follow any local or state regulations regarding the disposal of needles and syringes that are no longer in use. Make sure you use a puncture-proof "sharps" disposal container (ask your pharmacist for one and what to do with the container away). Make sure this container is away from animals and children.

You might need to monitor your pulse before and after the injection. If your pulse is fast, reduce or cease the treatment until the pulse rate is back to normal.If you're using human antihemophilic factors, you may require regular blood tests.Your body can develop antibodies against antihemophilic factor, and this can make it less efficient. Consult your physician. If this medication appears to not be as effective in reducing the bleeding,Follow all directions on how to store the medicine. Each type of human antihemophilic factor could include specific storage guidelines.The medicine and the diluting solution were in the original container within the fridge. Don't freeze. Before preparing your dosage, remove these items from the refrigerator and allow them to reach room temperature.It is also possible to store the diluent and medication at room temperature up to the end date on the prescription label. Certain medicines can be kept at room temperature only for the specified amount of time up to the date of expiration (whichever occurs first). Follow the instructions for storage on the label.If you keep this medication at room temperature, don't bring it back to the refrigerator.Don't store this medication in direct sunlight. Dispose of any remaining medicine and diluent when the expiration date has come and gone.Wear a medical alert tag or carry an ID document stating that you suffer from hemophilia. Any dentist, doctor, or emergency medical professional who cares for you must know you have an issue with blood clotting or bleeding.

What happens if I miss the dose?

Human antihemophilic factor can be utilized only in the event of need and you might not be on a dose schedule. If you're in a routine, you should take the missed dose as quickly as you can remember. Do not take your missed dosage if you are close to the time of the next dose scheduled. Don't use any extra medication to replace the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding any restrictions on your food, drink, or activities.

Interaction with other drug

Other medications can interact with human antihemophilic factors, such as prescription and over-the-counter drugs, vitamins, and herbal remedies. Be sure to inform your health professionals about any medications you take currently and all medicines that you decide to stop or modify your use of.