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Cedazuridine and decitabine

What is Cedazuridine and decitabine?

Cedazuridine combined with decitabine can be used to treat certain types of myelodysplastic disorders (blood or bone marrow disorders).Cedazuridine or decitabine can be used in other ways not mentioned in this guide.

Side effects of Cedazuridine and decitabine

Symptoms of allergic reaction that you should seek medical help for include hives, difficulty breathing and facial or throat swelling.

Cedazuridine or decitabine can cause serious side effects. If you experience:

  • Easy bruising, unusual bleeding, or purple or red patches under the skin
  • Low red blood cells (anaemia): pale skin, unusual fatigue, feeling lightheaded or hort of breath,, cold hands and/or feet
  • Low white blood cell count: fever; mouth sores or skin sores; sore neck; cough.
  • Signs of a lung infection include fever, chills, a mucusy cough, chest pains, and shortness of breath.

If you experience certain side effects, your treatment may be halted or delayed.

Some of the common side effects associated with cedazuridine or decitabine include:

  • Fever and low blood cell count
  • The bruised or bleeding area;
  • Abnormal liver function tests
  • Feeling tired, having a headache, or having dizziness?
  • Your arms or legs may experience swelling.
  • Joint or muscle pain
  • Painful mouth sores;
  • Shortness of breath, lung infection
  • Nausea, loss of appetite
  • Diarrhoea, constipation;
  • Is a rash
  • Cold symptoms include stuffy noses, sneezing, coughs, and sore throats.

There may be other side effects. Call your doctor immediately if any adverse side effects arise; otherwise contact the FDA's Hotline at 1-800-FDA-1088 in order to report adverse events.


Cedazuridine, decitabine, and other drugs can affect your immune system. You could get more serious infections, including fatal ones.

Before you take this drug

Tell your doctor immediately of any of the following symptoms:

  • Kidney disease
  • Liver disease.

Before beginning treatment, a pregnancy test should be taken. Cedazuridine or decitabine may harm an unborn child or cause birth defects if either the mother or father uses cedazuridine or decitabine.

  • Do not take cedazuridine or decitabine while pregnant if you're a woman. Use birth control during treatment and for 6 months following your last dose.
  • Use effective birth control if you're a man and your partner can get pregnant. Continue to use birth control at least three months after your last dose.
  • Do not hesitate to tell your doctor if you become pregnant while using this medication.

Cedazuridine (and decitabine) can affect men's fertility. It is still important to use birth control to avoid pregnancy, as the medication can harm an unborn child. Cedazuridine or decitabine should not be taken for 2 weeks following your last dose. Cedazuridine or decitabine should not be used by anyone under the age of 18.

How to take Cedazuridine and decitabine?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed. Cedazuridine is administered in 28-day cycles. The medicine may only be needed during the first five days of a cycle. Your doctor will decide how long you should take this medication.

Cedazuridine or decitabine should be taken on an empty stomach at least two hours before or after eating. Take your medicine every day at the same time. Do not chew or crush the tablet.

You should not stop taking a medication or change the dose without consulting your doctor. Other medications may be prescribed to prevent nausea or vomiting. Continue to take the medication as prescribed by your doctor.

Do not take another dose if you vomit soon after taking decitabine and cedazuridine. Do not take another dose until you have taken your next scheduled dosage. Cedazuridine and decitabine can affect your immune system. You could get more infections, including serious or deadly infections. You will need to be examined by your doctor on a regular schedule. Store away from moisture or heat at room temperature. Store each tablet in its blister pack until ready to use.

Details on dosage

Adult dose for myelodysplastic syndrome:

One tablet (containing 100 mg of cedazuridine and 35 mg of decitabine) orally on Days 1–5 of every 28-day cycle Continue for at least 4 cycles or until the disease progresses or toxicities are unacceptable.
Consider administering antiemetics before each dose to reduce nausea and vomiting.
Use: For myelodysplastic syndromes (MDS), including previously treated and untreated de novo and secondary MDS with the following French-American-British subtypes (refractory anaemia, refractory anaemia with ringed sideroblasts, refractory anaemia with excess blasts, and chronic myelomonocytic leukaemia [CMML]) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups

What happens if I miss the dose?

If you miss a dose, take it as soon as possible. However, if the missed dose is more than 12 hours late, skip the dose. Take only one dose at a time. Continue to take all the daily doses of the treatment cycle, even if it means adding an extra day.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Cedazuridine or decitabine should not be taken for 2 hours prior to or after eating.

Interaction with other drug

Cedazuridine or decitabine may be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop using.




Prescription only

Pregnancy & Lactation

CSA Schedule*

Generic name: cedazuridine and decitabine [SED-az-URE-i-deen-and-de-SIT-a-been]
Brand name: Inqovi
Oral tablet (100–35 mg)
Combinations of antineoplastic drugs

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