The Web Health



Generic name: Hyaluronidase (injection) [HYE-al-ureON-i-dase]
Brand name: Amphadase, Hylenex, Vitrase
Classification of drugs: miscellaneous uncategorized agents

What is Amphadase?

Amphadase is a gene-engineered protein that has been genetically engineered.Amphadase is a component of fluids that are injected into your body in order to relieve water deficiency. Hyaluronidase is also used to aid in helping your body absorb other medicines.Amphadase also helps assist in ensuring that contrast dyes inside your body appear more clearly when you look at certain types of x-rays or scans.


Drug interactions that are serious can happen when certain medications are used alongside amphadase. Discuss with your doctor your medications and the dosages you use.Before taking Amphadase, inform your physician whether you're taking any of the following medications: furosemide (Lasix) and the drug phenytoin (Dilantin), as well as an anti-anxiety or sedative (such as Valium, Xanax, or Tranxene), aspirin or salicylates, cortisone or ACTH (Corticotropin), oestrogens, and antihistamines (such as a cold or allergy medication).The doctor might perform an examination of your skin prior to using amphadase in order to determine if you are allergic to the hyaluronidase.

Prior to use this drug

It is not recommended to be treated by amphadase if you are allergic to hyaluronidase.The doctor could conduct a skin test to determine if you're allergic to hyaluronidase before you take the medication.

Certain medications can trigger unwanted or harmful effects when they are taken in conjunction with amphadase. Your physician might need to alter your treatment plan in the event that you are taking any of the following medications:

  • Furosemide (Lasix);
  • Phenytoin (Dilantin);
  • A sedative or an anxiety medicine (such as diazepam or lorazepam; alprazolam Valium, Xanax, Tranxene, Ativan, and many others);
  • Salicylates or aspirin;
  • Cortisone or ACTH (corticotropin);
  • Oestrogens;
  • An antihistamine (such as an allergy or cold medication).

Inform your doctor if you are expecting or planning to be pregnant.It might not be safe to breastfeed while taking amphadase. Talk to your doctor regarding any risks.

Similar/related drugs

hyaluronidase, Hylenex, and dexrazoxane

How to take Amphadase?

Amphadase can be injected under the skin. It can also be injected into muscle or into other body tissues.A doctor will administer this injection.Amphadase shouldn't be injected into veins (as an injection intravenously).

What happens if I miss the dose?

Since you'll be receiving amphadase in a clinical setting, you're not likely to miss a dose.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding any limitations on foods, drinks, or activities.

Side effects of Amphadase

Seek medical attention immediately. If you are experiencing symptoms that indicate an allergic reaction, amphadase asthmatic hives or swelling of your lips, face, and throat.

Consult your physician right away. If you experience any of the common side effects from amphadase, like:

  • Swelling in your feet, hands, or other body parts swelling in your hands, feet, or other body areas
  • Discomfort, swelling, itching, or redness at the site of the injection.

This list does not encompass every possible side effect.Others could happen.Consult a medical expert if experiencing adverse side effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications can interfere with hyaluronidase. This includes medications that are prescribed and available over the counter, as well as vitamins and herbal products. Be sure to inform your health professionals about any medications you take in the present and about any medication you stop or start taking.