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Generic name: hyaluronidase (injection) [HYE-al-ure-ON-i-dase]
Brand names: Amphadase, Hylenex, Vitrase
Drug class: unclassified agents

What is Vitrase?

Vitrase is an engineered protein.Vitrase can be used in conjunction with fluids injected directly into the body for the treatment of dehydration. Hyaluronidase is also used to help your body absorb other medications you inject.

Vitrase can also be used to make contrast dyes more visible on certain types of x-rays and scans.


Vitrase can cause serious drug interactions when used with certain medications. Please inform your physician of all medications you are currently taking.

Tell your doctor if any of these drugs are being used: furosemide, phenytoin, Xanax or Tranxene, aspirin, salicylates, corticotropin, ACTH, oestrogens, or antihistamines (such as a cold medicine or allergy medication).Before using Vitrase, your doctor may conduct a skin test to determine if you're allergic to hyaluronidase.

Before you take this drug

Vitrase should not be used if you have an allergy to hyaluronidase.Before you take the medication, your doctor may conduct a skin test in order to determine if you're allergic to hyaluronidase.

Certain medicines can have unwanted or harmful effects when combined with hyaluronidase. If you take any of these drugs, your doctor may have to alter your treatment plan.

  • Furosemide (Lasix)
  • Phenytoin (Dilantin)
  • A sedative (such as Valium, Xanax, or Ativan) or an anxiety medicine
  • Aspirin and salicylates
  • Cortisone or ACTH (corticotropin);
  • Oestrogens;
  • Antihistamines (such as cold or allergy medicines)

Inform your doctor of any pregnancy or plans to become pregnant.Vitrase may cause problems if breast-feeding is being done. You should consult your doctor if you are concerned about any risks.

Similar/related drugs

Hyaluronidase, Hylenex, Amphadase, and Dexrazoxane

How to take Vitrase?

Vitrase can be injected into the muscle or other tissues.Vitrase is administered by a healthcare professional.Vitrase shouldn't be injected intravenously (into a vein).

What happens if I miss the dose?

You are unlikely to miss a dosage because you will be receiving Vitrase in a clinic setting.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Side effects of Vitrase

If you experience any of the following symptoms of an allergic reaction to Vitrase: difficulty breathing, swelling of the face, lips, throat, or tongue

If you experience any of these common Vitrase side effects, call your doctor immediately.

  • You may experience swelling of your hands, feet, or other parts of the body.
  • An injection may result in pain, swelling, itching or redness at its site of administration.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Interaction with other drug

Other drugs, such as prescription and over-the-counter medicines, herbal products, vitamins, and supplements, may also interact with hyaluronidase. Inform your healthcare providers of all the medicines you are taking and those you plan to take.