The Web Health



Generic name: or  pantoprazole (oral/injection) [pan-TOE-pra-zole]
The brand name is Protonix.
Drug class: Proton pump inhibitors

What is Pantoprazole?

Pantoprazole is a proton pump inhibitor that reduces the amount of acid that is produced by the stomach. Pantoprazole can be used to treat the condition known as erosive stomachitis (damage of the stomach due to stomach acids that is caused by gastroesophageal reflux disorder, or GERD) in adults and young children who are at or above five years old. Pantoprazole is typically prescribed for at least 8 weeks until your oesophagus is healed.Pantoprazole can also be used to treat Zollinger-Ellison disorder and other ailments that require excessive stomach acid.


Pantoprazole is not a remedy for instant relief from the symptoms of heartburn. Heartburn can be confused with the first signs of an attack on the heart. Take immediate medical attention when you experience chest pain, a heavy feeling, pain that extends to the shoulder or arm, nausea, sweating, or a general feeling of ill-health. The long-term use of pantoprazole could cause difficulty for the body to absorb Vitamin B-12, which could result in a deficit in this vitamin. Discuss this with your doctor in the event that you require long-term pantoprazole treatment and are concerned about vitamin B12 deficiency. Pantoprazole could cause kidney issues. Tell your doctor when you're urinating less than normal or if you notice some blood in the urine. Diarrhea could be an indication of an infection that has just started. Consult your physician in the event of diarrhea that is swollen or has the presence of blood.Pantoprazole can result in the onset or escalation of symptoms of Lupus. Inform your doctor if you are experiencing joint pain and a rash of skin on your arms or cheeks that gets worse in the sun. You could be more likely to sustain fractured bones while taking this medicine for long periods of time or more than once per day.

Before Taking this Medication

Heartburn is a common sign of a cardiac attack. You should seek medical assistance immediately when you are experiencingare symptoms of chest pain that is spreading to your shoulder or jaw and when you are feeling anxious or lightheaded.

This medicine If:

  • Also, you may take a medication that contains the ingredient rilpivirine (Edurant Complera, Edurant, Juluca, Odefsey);
  • If you have had breathing issues, kidney issues, or a severe allergic reaction to pantoprazole previously,
  • You have an allergy to pantoprazole or other similar medications (lansoprazole and omeprazole, Nexium, Prevacid, Prilosec, and more).

Speak to your doctor if you have ever suffered from:

  • The magnesium levels in your blood are low.
  • Lupus; or osteoporosis, or low bone mineral density.

There is a higher chance of suffering a fractured bone if you are taking pantoprazole for a long time or more than a day. Discuss with your physician ways to maintain your bones' health, particularly if you're an older adult.It isn't known if this medication will affect a newborn baby. Inform your doctor if you are expecting or planning to be pregnant.It is not recommended to breastfeed when taking this medication.Pantoprazole is not a prescription drug for use by children younger than five years old.

How to Take Pantoprazole?

Follow the exact dosage as directed by your physician. Follow all instructions on the prescription label and study all medication guides or instruction sheets. Make sure you use the medicine precisely as prescribed. Take the dose that is lowest and will last the least amount of time required to cure your problem. Pantoprazole is consumed by mouth (oral) or administered by infusion to the vein (injection). The healthcare professional may instruct you on the proper use of the injection on your own. Pantoprazole tablets can be taken by mouth, whether with or without meals. The granules for oral use should be consumed 30 minutes prior to eating. Do not chew, crush, or tear your tablet. Take it in whole. The oral granules must be mixed with apple juice or applesauce and administered either through the mouth or via the Nasogastric (NG) tube.

Follow and read carefully any instructions that are included along with your prescription. Consult your physician or pharmacist for any additional concerns. Make sure to take this medicine for the entire prescribed duration, even if symptoms do not improve immediately.

Consult your physician if your symptoms don't improve or worsen during the course of this medication.Pantoprazole could produce false results in certain tests for medical purposes. Inform your doctor or lab personnel that you're using this medication.Pantoprazole can also alter the results of a urine test for drug screening and cause inaccurate results. Inform the lab staff that you are taking this medication.Place this medicine in a refrigerator at room temperature that is free of heat, moisture, and light.

Details on Dosage

Usual Adult Dose for Erosive Esophagitis:

Treatment of Erosive Esophagitis:
40 mg once orally, every day, up to 8 weeks. However, an additional 8 weeks could be considered for patients who haven't recovered from the initial treatment. The safety and effectiveness of this treatment after 16 weeks of treatment have not yet been established.

Maintenance of Healing of Erosive Esophagitis:
40 mg once orally, every day. The controlled studies have been limited to 12 to 18 months of therapy with pantoprazole.

Usual Adult Dose for Gastroesophageal Reflux Disease:

Adults: 40 mg twice daily for 7–10 days, administered through intravenous injection over a period of between 15 and 30 minutes. Injecting intravenous therapy should stop when the patient is in a position to resume oral treatment.

For oral use, 40 mg is taken orally daily for short-term treatment (up to 8 weeks), but the possibility of an additional 8 weeks can be considered in the case of patients who have not fully recovered following the initial treatment. The safety and effectiveness of this treatment after 16 weeks of treatment have not been proven.

Usual Adult Dose for Duodenal Ulcer:

Study (n=54)
40 mg once per day. The dosage was increased each 12 weeks in increments of 40 mg, up to a maximum of 120 mg daily for 28 weeks. The results of the study have shown that monotherapy with daily doses of 20 mg is connected with total healing of the duodenal ulcer in up to 87% and 94 percent of patients following 4 and 8 weeks, respectively.

Usual Adult Dose for Gastric Ulcer:

40 mg taken orally every day. Studies have shown that monotherapy using dosages daily of up to 40 mg has been linked to the complete healing of gastric ulcers, with up to 87% and 97 percent of patients following 8 and 4 weeks, respectively.

Usual Adult Dose for Helicobacter pylori Infection:

Study (n = 242): Triple therapy:
40 mg taken orally twice a day for 7 days Usually when used in conjunction with clarithromycin, metronidazole, or amoxicillin to eliminate Helicobacter pylori. This is followed by 40 mg of pantoprazole taken orally every day up to day 28. Triple therapy has produced an eradication rate of more than 95 percent.

The Quadruple Study (n = 405): Quadruple therapy:
40 mg twice a day orally for 7 days. It is taken in conjunction with bismuth subcitrate as well as tetracycline, each four times a day, and metronidazole, 200 mg three times a day and 400 mg at night. Helicobacter Pylori elimination was achieved in 82 percent of patients.

Usual Adult Dose for Zollinger-Ellison Syndrome:

Parenteral: 80 mg once every 12 hours, administered via 15 minutes of infusion. Daily doses greater than 240 mg administered in equally divided doses with 15 minutes of infusion or for longer than 6 days have not been investigated.

Oral: 40 mg once a day for a maximum of 242 mg daily. Certain patients have been treated with pantoprazole for over 2 years.

Usual Adult Dose for Stress Ulcer Prophylaxis:

Study (n = 21): Stress Ulcer bleeding prevention within the Critical Care Setting:
80 mg twice a day, as a bolus-infusion for fifteen minutes, up to a maximum daily dosage of 240 mg, broken into three equal doses.

Study (n = 20): 20 participants received peptic ulcer prophylaxis for rebleeding after an hemostasis within the Critical Care Setting:
Infusion of 80 mg, then a continuous infusion of 8 mg/hr over 3 days. Following this, the treatment may be repeated using an oral PPI.

Usual Adult Dose for Peptic Ulcer:

Study (n = 21): Stress Prophylaxis for Bleeding from Ulcers within the Critical Care Setting:
80 mg twice a day, as a bolus infusion spread over 15 minutes, for a total daily dose of 240 mg broken into 3 equal doses.

Study (n = 20) Study (n = 20) of peptic ulcer prophylaxis to prevent rebleeding following bleeding in the Critical Care Setting:
Infusion of 80 mg, then a continuous infusion of 8 mg/hr for three days. Following this, treatment can be repeated with the use of an oral PPI.

What Happens If I Miss a Dose?

Utilize the medicine as quickly as you can; however, do not miss your missed dose if it's nearing the time to take the next dose. Do not take two doses at once.

What Happens If I Overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What Should be Avoided?

This medication can induce diarrhea. This can be a sign of a new infection. If you experience diarrhea that is bloody or watery, contact your physician. Do not use the anti-diarrhea medication unless your doctor has told you to.

Side Effects of Pantoprazole

See a doctor immediately. If you are experiencing symptoms that you are experiencing an allergic reaction due to the drug pantoprazole, such as itching, breathing difficulties, or swelling of your lips, face, and tongue.

See your doctor right away. If you are suffering from:

  • Extreme stomach discomfort; vomiting that is bloody or watery;
  • Unintentional pain or discomfort in your wrist, hip, or back
  • Swelling or bruising after intravenous pantoprazole injections were administered;
  • Kidney issues (fever, rash, nausea, lack of appetite, not urinating as often as usual, the presence of blood or urine in your system, excess weight)
  • Low magnesium dizziness, rapid or irregular heartbeat, shaking (shaking) or muscles that jerk and feeling nervous, muscle spasms or cramps, cramps in your feet and hands, coughing or a choking sensation,
  • New or worsening symptoms of Lupus joint pain and a rash that appears on your arms or cheeks that gets worse in the sun.

Long-term use of pantoprazole can cause stomach tumors, also known as fundic gland polyps. Consult your doctor regarding this danger. If you take pantoprazole for more than three years, you could be developing vitamin B-12 deficiencies. Discuss with your physician how to deal with this issue in the event that you are diagnosed with it.

Common side effects of pantoprazole include:

  • Headache, dizziness;
  • Stomach pain, gas, nausea, vomiting, and diarrhea;
  • Joint pain, fever or rash. signs of a cold (most frequent in children).

This isn't a complete list of all the side effects. Other side effects could be present. Consult your physician for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with Other Drugs

Inform your doctor about any other medications you are taking. Certain medicines may interact with pantoprazole, particularly:

  • Digoxin;
  • Methotrexate; or
  • A diuretic is also known as a "water pill."

This list isn't complete. Other medications could influence pantoprazole. This includes medications that are prescribed and available over the counter, such as vitamins and medicines, as well as natural products. There are many possible interactions between drugs, which are included here.