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Remodulin (injection)

Generic name: treprostinil (injection) [tre-PROS-ti-nil]

Brand name: Remodulin
Drug class: agents to treat pulmonary hypertension

What is Remodulin?

Remodulin widens your arteries (dilates) and reduces the number of platelets that clot blood in your body. These effects reduce blood pressure in the pulmonary arteries that lead from the heart to the lungs.Remodulin is used in the treatment of pulmonary arterial hypertension (PAH). Remodulin can improve your ability to exercise and help you prevent your condition from worsening.This medication guide does not list all possible uses of Remodulin.

Side effects of Remodulin

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of the face, lips, or throat.A catheter placed in your intravenous line can increase the risk of developing a severe infection known as sepsis. When using intravenous remodulin, be aware of symptoms like fever, flu symptoms, mouth and throat ulcers, rapid heart rate, or rapid and shallow breath.Call your doctor if you notice any of the symptoms.

Remodulin can cause serious side effects. If you experience:

  • Pain, swelling, redness, or bleeding where the catheter has been placed;
  • You may experience swelling in your hands or feet.
  • A feeling of lightheadedness, as if you could pass out.
  • Symptoms of PAH (fatigue, pallor, chest pain, difficulty breathing) worsen.

Remodulin can cause the following side effects:

  • Pain, swelling, bruising, or bleeding around the catheter
  • Jaw pain;
  • Diarrhea, nausea,
  • Flushing (warmth, redness, or tingling)

There may be other side effects. Call your doctor for medical advice about side effects. To report adverse effects, you can contact the FDA at 1-800-FDA-1088.

Similar/related drugs

Sildenafil, Tadalafil, Adcirca, Revatio, Ambrisentan, and Opsumit


You should read the entire label and package instructions before taking your medicine. Tell your doctor about any medical conditions you may have, including allergies and medications.

Before you take this drug

If you have an allergy to remodulin, do not use it.

Inform your doctor if you experience any of these symptoms:

  • Liver disease
  • Kidney disease is a serious condition.

You should not stop or start using Remodulin without consulting your doctor. PAH can be harmful to both mother and child. If you become pregnant, inform your doctor as soon as possible.Remodulin may make it unsafe to breastfeed. You should consult your doctor if you are concerned about any risks.

How to take Remodulin?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the medication. This medicine may be needed for many years.Your first dose may be administered in a hospital setting or clinic to treat any serious side effects.Remodulin can be given continuously using an infusion device attached to a catheter that is placed either under the skin (subcutaneously) or directly into a vein. You can learn how to use the infusion pumps by yourself with the help of a healthcare provider.Please read and follow all instructions for use that come with your medicine. Remodulin should not be used if you do not understand the instructions. Ask your pharmacist or physician if you have questions.Remodulin may be mixed with a liquid. You should know the correct way to store and mix your injections if you plan on using them yourself.Prepare your injection only when you are ready to administer it. If the medication has become discolored or contains particles, do not use it. For new medication, call your pharmacist.If your symptoms don't improve or worsen, call your doctor.

You shouldn't reduce your dosage or stop Remodulin abruptly. Your condition may worsen if you stop suddenly.You may need a backup infusion pump, batteries, and infusion sets to ensure that your treatment is not interrupted. Refill your prescription before you run completely out.Keep unopened treprostinil vials or bottles at room temperature, away from heat and moisture. After 30 days, throw away the vial, even if it still contains medicine.You will have to use your medicine within a few hours or days after mixing it. The type of diluent you use and whether or not you store your mixture in the refrigerator or at room temperature will determine the time frame. Follow the instructions for mixing and storing your medicine. If you have any questions, ask your pharmacist.Only use a needle or syringe once, and then store them in a "sharps container" that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.

What happens if I miss the dose?

Remodulin can be taken at any time, so you shouldn't miss a dosage if you take it properly. If your Remodulin treatment is interrupted, call your doctor immediately.

What happens if I overdose?

For poison assistance, call 1-800-222-1222 or get immediate medical help.The symptoms of an overdose may include tingling, warmth, or diarrhea.

What should be avoided?

Follow your doctor's instructions if he or she prescribes restrictions on food, drink, and activity.

Interaction with other drug

Taking certain medicines together can be dangerous.Some drugs may affect the blood levels of drugs that you are taking, causing side effects or making them less effective.Remodulin may be affected by other drugs, such as vitamins and herbal supplements. Tell your doctor about all medications you take, including those you start or stop using.