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Generic name: rilonacept [ ril-ON-a-sept ]
Drug class: Interleukin inhibitors

What is Arcalyst?

Arcalyst can be used to treat certain symptoms of rare genetic disorders like Familial Cold Auto-Inflammation Syndrome (FCAS) or Muckle-Wells Syndrome (MWS).MWS and FCAS are conditions that cause inflammation in which the body experiences certain symptoms when exposed to heat, cold, stress, or fatigue. These symptoms usually include rashes as well as fever, joint pain, and eye irritation and discomfort. The more serious symptoms could be deafness as well as kidney disease.Arcalyst could treat or help stop some symptoms of Familial Cold Auto-Inflammation Syndrome (FCAS) or Muckle-Wells Syndrome (MWS) in children and adults who are less than 12 years old.Arcalyst can also be used to treat symptoms of a disorder known as deficiency in the interleukin-1 antagonist (DIRA), which is a condition that affects adults and children weighing at least 22 pounds (10 kilograms). DIRA is a rare genetic condition that can trigger an extreme inflammatory reaction in the early days of life. It can result in an organ malfunction throughout your body.Arcalyst is not an effective treatment for these genetic ailments.Arcalyst can also be utilised to treat episodes of repeated pericarditis (RP) in adults and children who are at least twelve years of age. The condition can trigger heartbeats that are pounding, breathing problems, and extreme chest pain that can spread into your neck or back.


Sometimes fatal and serious infections could occur while using Arcalyst. Contact your doctor immediately if you notice symptoms of infection, such as fever, chills, sore throat flu symptoms, or open sores that are visible on your body.Arcalyst should not be used in the event that you are allergic to rilonacept or suffer from any disease.Before you start using Arcalyst, consult your doctor if you have an ongoing or persistent illness, a previous history of tuberculosis or repeated infections, or have high cholesterol levels or high triglycerides. Check to see if you're up-to-date on your vaccinations prior to when you begin treatments with an arcalyst.Discuss with your doctor the other medications you are taking, particularly those that treat psoriasis, arthritis, Crohn's disease, or ankylosing spondylitis.Don't receive a "live" vaccine while using Arcalyst. The vaccine may not function in the same way during this period and might not completely safeguard you from illness. Beware of coming into contact with someone who recently received a live vaccination. There is a possibility that the virus will be transmitted to you.

Similar/related drugs

Kineret, Anakinra, Ilaris, Rilonacept, and Canakinumab

Before you take this drug

It is possible that you will not be able to use Arcalyst in the event that you suffer from an active infection.

Inform your physician if you are showing any indications or symptoms of an illness (fever, cough and flu symptoms, open sores) or if you have ever suffered from:

  • An ongoing or chronic disease that is chronic or active, such as HIV;
  • Hepatitis B and C;
  • Tuberculosis (or if someone in your family has tuberculosis);
  • An immune system that is weak (caused through illness or the use of certain medications);
  • Diabetes;
  • Asthma
  • High cholesterol, also known as triglycerides (a type of fat found in the blood),Be sure to be current on all vaccines prior to when you begin treatment with Arcalyst.Utilising Arcalyst could increase your chances of getting certain kinds of cancer. Discuss with your physician the risk you face.Consult a physician if you are breastfeeding or pregnant.

How to take Arcalyst?

Utilize Arcalyst precisely as directed by your physician. Follow the instructions on the label of your prescription and study all medication guides or instructions sheets.Arcalyst is injected beneath the skin each week. Doctors will show patients how to take medications themselves.Your doses could be administered in two or one injection at one time, each in the same spot within your body.Arcalyst is combined with liquid (diluent) prior to using it. When you inject yourself, ensure that you know how to prepare and maintain the medication.Choose a different spot on your thigh, stomach, or upper arm every time you inject. Your physician will guide you to the most appropriate locations where you can inject your medicine. Make sure you don't inject in the same spot twice in consecutive days.If you take Arcalyst, you might need to conduct regular blood tests.Every throughl (bottle) is for a single usage only. It is discarded after just one use, regardless of whether there's still medicine in it.Use a needle or syringe only once and put them in a puncture-proof "sharps" container. Be sure to follow the laws of your state or city regarding how to dispose of the container. Make sure it is out of reach of pets and children.Keep the powder that is not mixed in the refrigerator, and keep it safe from sunlight. Don't freeze. Retain each vial in the original container until you're ready to mix your medication.After mixing Arcalyst and a diluent, keep it at room temperature before using the product within three hours. Be sure to protect it from sunlight.

What happens if I miss the dose?

Contact your doctor for advice in case you missed a dose.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Don't receive the "live" vaccine while using Arcalyst. The live vaccines are measles, rubella, and mumps (MMR), as well as rotavirus, yellow fever, typhoid varicella (chickenpox), the zoster (shingles), and the nasal influenza (influenza) vaccine.Talk to your doctor prior to receiving an influenza vaccination or flu vaccine if you are taking Arcalyst.

Side effects of Arcalyst

Take immediate medical attention. If you are experiencing symptoms that indicate an allergic reaction, such as hives, breathing problems, or swelling of your lips, face, or tongue,You could contract infections more frequently, and even a severe or fatal infection.
Call your doctor immediately if you notice symptoms of infection, like:

  • Fever chills, fever colds, sore throat
  • Open sores on your body
  • Cough, mucusy feeling, sluggishness;
  • Headache stiff neck more sensitive to light
  • Chest pain, wheezing, a dry cough, and rapid weight loss.

Make sure to contact your doctor at any time if you suffer from:

  • Bloody, black, bloody, or tarry stool;
  • Vomit or bloody vomit that resembles coffee grounds
  • Coughing, chest tightness, trouble breathing
  • Discomfort or burning sensation during urination; or
  • Symptoms of an ear infection, such as headache, fever, or complete feeling, hearing problems, draining from the ear, and a general feeling of discomfort in children.

Common side effects of arcalyst include:

  • Signs of a cold, like nasal stuffiness, a runny nose, and sneezing. Also, sore throats;
  • Otitis externa;
  • Joint or muscle pain;
  • It can be a rash
  • Swelling, redness, pain, discomfort, itchiness, bleeding, blisters, an itch, or a lump in the area at the site of injection.

This isn't a complete list of all the side effects. Other side effects could occur. Contact your physician for advice regarding medical adverse effects.Please notify the Food and Drug Administration of any adverse side effects by dialing their number: 1-800-FDA-1088.

Interaction with other drug

Inform your doctor about any other medications you take, particularly:

  • Adalimumab;
  • Certolizumab;
  • Etanercept;
  • Fingolimod;
  • Golimumab;
  • Infliximab;
  • Leflunomide;
  • Warfarin (coumadin and jantoven);
  • Steroid medicine such as prednisone.

This list isn't complete. Other medications can be incompatible with rilonacept, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs, which are included here.