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Generic name: Anakinra [an-na’KIN-rah [an-na-KIN-rah]
The brand name is
Dosage form: subcutaneous solution (100 mg/0.67 mL)
Drug classes: antirheumatics, interleukin inhibitors

What  is Akinra?

The US Food and Drug Administration (FDA) has granted emergency use of anakinra in treatments for COVID-19 in patients who have had a positive test for COVID-19, with pneumonia that requires supplemental oxygen, who are most at risk of suffering acute respiratory problems and are most likely to have a higher chance of a worsening disease (measured by the abnormality in blood levels of a specific protein).Anakinra is not cleared to treat coronavirus or COVID-19.Anakinra is a medication used to treat symptoms of severe to moderate rheumatoid arthritis, which is severe to moderate among adults. Anakinra can also aid in slowing the progression of the condition. Anakinra is usually prescribed following the conclusion that various arthritis medications have failed or been unable to work.Anakinra may also be utilised for newborns for the treatment of a genetic disorder called neonatal-onset multisystem inflammatory illness (NOMID). NOMID is a type of cryopyrin-associated chronic syndrome (CAPS). The condition can cause uncontrolled inflammation in a variety of parts of the body, which include joints, the skin, and the central nervous system.Anakinra can also be used to treat symptoms of a condition known as Deficiency of Interleukin-1 Receptor Antagonist (DIRA) for both children and adults. DIRA is a rare genetic condition that can cause an intense inflammatory reaction in the early days of life. It can result in kidney failure in the entire body.Anakinra could also be used to treat conditions not covered in this medication guide.

Similar/related drugs

Simponi, Paxlovid, Hydroxychloroquine, Humira, Enbrel, Remicade, and Rituxan

Side effects of Anakinra

Contact emergency medical assistance if you are experiencing symptoms that indicate an allergy, such as sweating, hives or extreme itching, wheezing, difficulty breathing, rapid or pounding heartbeats, fainting, dizziness, or swelling of your lips, face, and tongue.If you're using Anakinra to treat DIRA You may be at an increased risk for allergies, particularly in the first few weeks of treatment.

Anakinra can cause severe adverse effects. Contact your physician immediately if you suffer from;

  • The fever and chills
  • Low white blood cell counts: mouth skin sores, mouth sores, sore throat;
  • Symptoms that suggest tuberculosis symptoms of tuberculosis are signs of tuberculosis: fever, cough, night sweats, and a loss of appetite. Losing weight and feeling exhausted.

Common negative effects of anakinra include:

  • Abnormal tests of liver function;
  • Rash;
  • Aggravation of arthritis symptoms;
  • Nausea, vomiting, diarrhea, and  stomach pain;
  • Headache;
  • Joint pain;
  • Flu symptoms;
  • Symptoms of the cold, like congestion, sneezing, or sore throats;
  • Itching, redness, swelling, and stinging in the area where the injection was administered.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.


The US Food and Drug Administration (FDA) has granted anakinra in the event of an emergency for COVID-19 treatment in patients in hospitals who have been found positive for COVID-19 with pneumonia that requires supplemental oxygen, those who have a high risk of suffering severe respiratory failure and are likely to be at an increased chance of getting worse of the condition (measured by the abnormality in blood levels of a specific protein).

Before you take this drug

Anakinra should not be used if you have an allergy to it or if you are suffering from:

  • An active infection;
  • An allergy to any medication that contains e. Coli bacteria proteins.

Speak to your physician if you have ever suffered from:

  • Kidney disease;
  • An ongoing or chronic infection;
  • Symptoms like chills, fever, or open skin sores;
  • An immune system that is weak (caused by illness or the use of certain medicines):
  • Asthma
  • Tuberculosis,
  • If you're scheduled to get a vaccine,

Consult your physician if you are expecting, planning to have a baby, or plan to breastfeed.Do not administer this medication to children without seeking medical advice. Anakinra is not authorised to treat rheumatoid joints for anyone under 18 years of age.

How to take Anakinra?

Follow the instructions on the prescription label and review all medication guides and instructions sheets. Follow the medication precisely as prescribed.Anakinra is injected beneath the skin. An experienced healthcare professional can teach you how to use the drug yourself.Anakinra is prescribed daily or every two days. Follow your doctor's instructions for dosing extremely carefully. Dose every dose during the same period each day when you take the medication.Your doctor will inform you of the best place on your body where you should inject your anakinra. Make sure to use a different location every time you give an injection. Each injection should be administered at least one inch from the area where you last injected the medication.Take note of and follow the instructions for use that come along with your medication. Talk to your pharmacist or doctor to clarify any instructions.Be careful not to shake the syringe you've filled, or you risk ruining the medication.Only inject it once you are ready to administer it. Don't use any medicine that appears unclear, has changed colour, or contains articles. Contact your pharmacist to inquire about a new medication.Contact your doctor if arthritis symptoms don't get better or worsen while taking anakinra.Anakinra influences the immune system. It is possible to contract infections more frequently. You'll need regular medical tests prior to and during taking anakinra and for a few months after quitting it.Place it in the refrigerator and avoid freezing. Keep away from sunlight. Discard any medicine that is not used following its time limit on the prescription label.Each syringe filled with prefilled medicine is intended for one usage only. It is best to dispose of it after just one usage, regardless of whether there's still medicine in it.Use a needle or syringe just once, and then put them into a punctureproof "sharps" container. Be sure to follow the laws of your state or city on how to dispose of the container. Keep it out of reach from pets and children.

What happens if I miss the dose?

Consult your physician for the correct dosage when you have missed a dose.

What happens if I overdose?

In case of medical emergencies, seek emergency care right away or contact the Poison Help Line immediately at 1-800-222-1222.

What should be avoided?

Do not get a "live" vaccine while using anakinra. You could get an infection. These live vaccinations comprise measles, rubella, mumps (MMR), and rotavirus. yellow fever, typhoid varicella (chickenpox), shingles, and the nasal virus (influenza) vaccination.Beware of those who are sick or suffering from infections. Contact your doctor right away when you begin to show symptoms of an infection.

Interaction with other drugs

There's a possibility that you have a higher chance of contracting anakinra when you are taking:

  • Certolizumab;
  • Etanercept;
  • Golimumab;
  • Infliximab;
  • Adalimumab;
  • Cancer drugs, steroids, or medications to help prevent organ donation

This list isn't complete. Other medications can influence anakinra, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs that are included here.




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