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Name of the generic: piroxicam (or peer-OX-i-Kam) peer-OX-iKam [peer-OX-i-kam]
Class of drug: nonsteroidal anti-inflammatory drugs

What is Feldene?

Feldene is a nonsteroidal antiinflammatory drug (NSAID) that is prescribed to treat inflammation and pain due to osteoarthritis or rheumatoid arthritis. Feldene is also employed for other purposes that are not covered in this guideline.

Side effects of Feldene

Seek medical attention immediately when you are experiencing symptoms that indicate an allergic reaction (hives and breathing problems and swelling in your throat or face) or an extreme skin reaction (fever and throat soreness, eye burning, irritation, and red or purple skin itching, blistering, and peeling).

Take immediate medical care. If you're experiencing symptoms of an attack on your heart or stroke: chest pain spreading into your shoulder or jaw A sudden feeling of weakness or numbness in one area of your body, slurred speech, swelling in your legs, or feeling short of breath

Stop taking Feldene as well as seek medical attention in the event of a serious drug reaction that affects various parts of your body. Symptoms may include the appearance of a skin rash or fever, swollen glands, muscle aches, abnormal bruising, severe weakness, or an increase in the color of your eyes or skin.

Feldene may cause serious side effects. Stop using Feldene and consult your doctor immediately. If you suffer from:

  • A severe headache severe headache, blurred vision pain in your neck or in your ears;
  • Heart issues: swelling rapidly, gaining weight, and feeling tired;
  • Issues with the liver: loss of appetite and stomach discomfort (upper right) fatigue, itching, dark urine, stools that are clay-colored, and jaundice (yellowing of the eyes or skin);
  • Symptoms of stomach bleeding: bloody or tarry stool, and vomiting blood or vomiting that appears like coffee grounds
  • Kidney problems: no or little urinary frequency; swelling in your ankles and feet; feeling exhausted or sluggish;
  • Low red blood cells (anemia)—pale skin uncharacteristically tired and feeling lightheaded or sluggish; cold hands and feet

Common adverse effects of Feldene could include:

  • Abnormal tests for liver function;
  • Problems with urination;
  • Uneasy stomach, heartburn, and loss of appetite. Nausea, sickness, vomiting;
  • Gas, diarrhea, constipation;
  • Dizziness, headache;
  • Itching, rash;
  • Your ears are ringing.

This isn't a complete list of all the side effects. Others could happen. Consult your physician to seek medical advice on adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar/related drugs

Simponi, aspirin, prednisone, acetaminophen, tramadol, ibuprofen, and meloxicam


Feldene increases the chance of suffering a fatal cardiac attack as well as a stroke. Don't use Feldene prior to or following coronary bypass surgery (coronary bypass grafts for artery CABG, also known as This medication can also trigger stomach or intestinal bleeding, which could lead to fatal bleeding.

Prior to use this drug

It is best not to take Feldene if you're allergic to it or if you've ever experienced an asthma attack or a severe allergic reaction following using aspirin or an NSAID.

Feldene may increase the risk of having a fatal heart attack or stroke, even when you do not have any risk factors. Don't take this medication prior to or following coronary bypass surgeries (coronary bypass grafts for the artery, also known as CABG).

Feldene can also trigger bleeding in the stomach or intestinal tract, which could be fatal. These problems can develop in a matter of minutes while taking this medicine and are more common in older people.

Speak to your doctor if you have ever suffered from:

  • Heart disease, high blood pressure, and smoking
  • A heart attack, stroke, or blood clot
  • A stomach ulcer or bleeding from the stomach (especially when using nsaids, such as NSAID);
  • Kidney or liver disease
  • Asthma or
  • If you are taking aspirin to avoid a heart attack or stroke,

If you are expecting, then you shouldn't take Feldene unless your doctor has advised you not to. Taking an NSAID in the final 20 weeks before birth may result in serious kidney or heart issues in the baby and may cause complications during the pregnancy.

Ovulation (the release of eggs from your ovary) can be delayed if you take Feldene. The effect is typically not lasting. It is not recommended to take this medication while trying to become pregnant. It might not be safe to breastfeed while taking this medication. Talk to your doctor regarding any risks. Feldene is not a drug that has been approved for use by anyone less than 18 years of age.

How to take Feldene?

Follow the directions on your prescription label and review all medication guidelines. The doctor could alter your dosage. Choose the lowest dose that works for treating your illness.

It may take as long as two weeks before symptoms begin to improve. Continue to take the medication according to the directions, and inform your physician if your symptoms don't improve. If you take Feldene over a long period of time, you could require regular medical testing. Keep at room temperature, free of heat and moisture.

What happens if I miss the dose?

Do not take the medicine for as long as you are able, but avoid your missed dosage if you are close to the time of the next dose. Don't have two doses at one time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222. The symptoms of an overdose can include vomiting, nausea, stomach pain, bloody or black stool, or coughing up blood.

What should be avoided?

Do not drink alcohol. It can increase the chance of bleeding from your stomach. Do not take aspirin while you take Feldene. Consult a physician or pharmacist before taking other medications for swelling, pain, fever, or cold or influenza symptoms. These medicines may contain ingredients that are similar to those in Feldene (such as aspirin, ibuprofen, ketoprofen, and naproxen)

Interaction with other drugs

Consult your physician before taking Feldene when you are taking medication for depression. Taking certain antidepressants together with an NSAID can cause bleeding or bruises easily.

Inform your doctor about any other medications you take, particularly:

  • Digoxin;
  • Lithium;
  • Methotrexate;
  • A blood thinner or any other medication to reduce blood clots
  • Blood pressure or heart-related medication, which includes diuretics and a "water pill"; or
  • Steroid medicine (such as prednisone).

This list is not exhaustive. Other drugs can interact with Feldene, such as medications that are prescribed and available over the counter, vitamins, and herbal products. The interactions of all drugs are included here.