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Generic Name: of Ethinyl Estradiol and Segesterone Vaginal Ring
The brand name is: Annovera.
Drug class: contraceptives

What is Annovera?

Annovera Vaginal Rings are made from silicone and are infused with two female hormones that release slowly in your vagina. They are then absorbed into your blood. The vaginal rings contain segesterone acetate and the hormone ethinyl estradiol.Annovera is commonly used by women as a contraceptive to avoid the onset of pregnancy.An Annovera vaginal ring can be used for as long as one year.


You shouldn't use Annovera if your condition is uncontrolled high blood pressure or heart issues, coronary artery disease and a decreased flow of blood towards your brain, chronic diabetes (or health issues due to diabetes) and undiagnosed vaginal bleeding and liver disease or cancer, extreme headaches, when you are also taking certain hepatitis C medications, or when you're scheduled for major surgery, or if you smoke and you are older than 35 or have suffered a heart attack or stroke, blood clot, and cancers of the breast, uterus, cervical, or vagina.It is not recommended to take Annovera if you are smoking and over 35 years old.Do not wear an Annovera vaginal ring when you are expecting or have recently had a child.

Before you take this drug

Annovera is not recommended for use in the event that you are allergic to segesterone, ethinyl estradiol, or:

  • Uncontrolled high blood pressure that is not controlled (especially when you have damaged blood vessels);
  • Heart-related problems (coronary arterial disease and heart rhythm disorders, an abnormal heart valve, or the history of a stroke, heart attack, or blood clots);
  • Diminished blood flow to the brain
  • An increased chance of getting blood clots because of a heart condition or hereditary blood disorder
  • Diabetic (and you are more than 35 years old or have had diabetes for longer than twenty years);
  • A health issue related to diabetes (vision problems, kidney issues) circulatory problems, nerve damage);
  • An antecedent history of hormone-related cancer as well as cancers of the breast, vagina, uterus, or cervix;
  • Unusual vaginal bleeding that hasn't been examined by the doctor
  • Headaches, migraines, or severe headaches accompanied by vision changes
  • Cancer of the liver or liver
  • If you have taken any hepatitis C medication containing ombitasvir, paritaprevir, or ritonavir in the past 2 weeks.

It is not recommended to use Annovera if you smoke and are over 35 years old. Using this medicine could increase the chance of developing stroke, blood clots, and heart attacks, particularly when you smoke.

To ensure that Annovera is safe for you, ask your physician if you've previously had:

  • Heart disease, high blood pressure, or if you're prone to blood clots
  • The highest cholesterol or triglycerides (a kind of fat found in the blood);
  • Liver disease, also known as jaundice (yellowing of your eyes or skin),
  • Kidney disease;
  • Diabetic, gallbladder disease;
  • Depression, migraine headaches, or a seizure;
  • Toxic shock syndrome, or simple vaginal irritation
  • A previous stroke in the family as well as an inherited history of breast cancer
  • A lump in the breast or fibrocystic breast cancer and an unusual mammogram
  • If you've recently experienced an abortion or miscarriage, abort.

Use an Annovera vaginal band if you are expecting or if you've been pregnant in the last 4 days. Call your doctor in case you don't have a period or suspect you might be expecting one.Breastfeeding is not advised when using Annovera.Annovera isn't a suitable choice for women who have not yet experienced menstrual periods or who are no longer experiencing menstrual cycles.

Similar or related drugs

Norethindrone, Medroxyprogesterone, Levonorgestrel, Provera, Depo-Provera, and Mirena

How to take Annovera?

Follow the directions for Annovera as given by your doctor. Follow the directions on the prescription label and go through all the medication guides or instructions on the label.The Annovera vaginal ring does not hinder pregnancy if worn only during intercourse. You must wear the ring at all times for three days (21 days).Within 21 days, you can remove the ring. Wait seven full days before inserting it again. Make sure to stick to the schedule for inserting and taking off the rings.Do not take the Annovera rings out of your vagina for two hours over the 21-day wearing period.If a ring gets snagged, clean it off with moderate soap and hot water. wipe dry on a fresh towel, and then insert it.

There is a possibility that you will need to use backup birth controls (condoms or spermicide, but not condoms for women) for seven consecutive days:

  • If the ring was removed from the vagina for longer than 2 hours in the 21-day wearing period,
  • If the Annovera ring has been removed from the vagina for a period of more than 7 days,
  • If you just had a child but haven't yet begun having periods,

There is a chance that you are experiencing breakthrough bleeding. Consult your physician if this bleeding persists for more than seven days or is extremely heavy.If you require major surgery or are in bed for a long time, you may need to discontinue taking Annovera for a brief period of time. Any surgeon or doctor who treats you should be aware that you're using Annovera's vaginal rings.Annovera is not able to protect against sexually transmitted illnesses, including HIV or AIDS. The use of a condom may help keep you safe from these diseases.When the ring falls out of the vagina, clean the ring using gentle soap and warm water. dry and keep it in the ring case that is provided. Store it at room temperature. Be sure to keep it away from the sun, heat, and freezing. Follow the guidelines to clean your Annovera vaginal ring whenever it is not being used.After having used an Annovera vaginal ring for a period of one year, throw away the ring that was used for vaginal purposes inside the case or pouch that it came in. Throw it away in a place where pets and children are not able to access it. Don't flush the ring into the toilet.

What happens if I miss the dose?

Contact your doctor when you're off the schedule or have difficulty removing the vaginal ring.

What happens if I overdose?

A high dose of Annovera is not likely to be a risk but could result in vomiting or vaginal bleeding.

What should be avoided?

Do not leave the ring on for more than three weeks.Don't use vaginal products that contain oil, like gel, cream, or a suppository. You can use a vaginal lubricant made of water, but not one that contains silicone or oil.Annovera can create dark spots on your face. Avoid tanning beds or sunlight. Protect yourself with protective clothes and apply sunblock (SPF 30 or more) whenever you're outside.You might want to avoid consuming the juice of grapefruit in conjunction with Annovera and certain other medications. Consult your physician or pharmacist.

Side effects of Annovera

Take immediate medical attention. If you are experiencing symptoms, you are experiencing an allergic reaction. Annovera. These include hives, breathing difficulties, and swelling of your lips, face, or tongue.

Contact your doctor immediately. If you suffer from:

  • Extremely hypertension Very high blood pressure; extreme headache fuzzy vision and pounding inside your neck or in your ears;
  • Indications of the presence of a blood clot: sudden weakness or numbness (especially for one leg) or a sudden and severe headache; difficulty speaking or vision; chest pain and feeling sluggish; the sensation of numbness or pain on one or both legs.
  • Warning signs of heart attacks heart attack symptoms: chest pain, pressure, pain that spreads to your shoulder or jaw, nausea, sweating, or vomiting;
  • Toxic shock syndrome: an abrupt fever, body aches, skin rash, vomiting, diarrhoea, and feeling lightheaded or dizzy;
  • New headaches and/or a modification in intensity or pattern in migraines.
  • Jaundice (yellowing of the eyes or skin)
  • Signs of depression mood swings and thoughts of harming yourself.

Some common side effects of Annovera could include:

  • Headache;
  • Nausea, vomiting, diarrhea, and  stomach pain;
  • Vaginal discharge or itching
  • Menstrual discomfort; tenderness of the breasts;
  • Irregular vaginal bleeding;
  • Discomfort or burning sensation during urination;

This isn't a complete list of possible side effects, and other side effects could be present. Contact your doctor for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drug

Certain drugs may cause birth control to be less effective and can lead to the birth of a baby. Make sure you use a barrier version that is birth control (a male condom containing Spermicide, but not condoms for women) together with an Annovera vaginal ring. Annovera vaginal ring if you are also using one of the following medications:

  • Aprepitant, bosentan, St. John's wort;
  • Antifungal medicine;
  • Antiviral medicine used to treat the symptoms of hepatitis C and HIV/AIDS;
  • Blood pressure medicine;
  • Seizure medicine;
  • Steroid medicine;
  • Thyroid medicine;
  • Tuberculosis

Use the birth control device that blocks your body from birth for a minimum of 28 days following your final dose of any one of the medications.Annovera may affect the blood levels of any other medications that you take, which can cause more side effects or make the drugs less efficient. Certain drugs may affect the levels in your blood of segesterone and ethinyl estradiol in the event that you are taking them in conjunction with wine or grapefruit juice.Inform your doctor about all your medications currently used as well as any medications you are about to start or stop taking. Numerous drugs can interact with Annovera, such as prescription and over-the-counter medicines, vitamins, and herbal supplements. The interactions with Annovera aren't all included here.