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Generic Name: Medroxyprogesterone (oral) [ me-DROX-ee-proe-JES-ter-one ]
Name of the Brand: Provera
Dosage Format: Oral tablet (10 mg; 2.5 mg; 5 mg)
Drug Classes: Contraceptives, hormones, antineoplastics, and progestins

What is Medroxyprogesterone?

Medroxyprogesterone tablets are utilized for treating irregular menstrual bleeding as well as irregular or missing menstrual periods (amenorrhoea) and also to stop the thickening of the uterus' lining (endometrial hyperplasia) in postmenopausal women who take estrogen hormone replacement therapy. Medroxyprogesterone is a hormone that stimulates progesterone production.


Medroxyprogesterone should not be used when you're pregnant or if you suffer from a disease of the liver, a hormone-related cancer like cancers of the uterus or breast, or an antecedent of stroke, blood clots, or vaginal bleeding that's not been detected by a medical professional.

Medroxyprogesterone shouldn't be used to treat heart diseases such as stroke, heart attack, or Alzheimer's disease. The medicine could increase the risk of getting the condition. In the long run, medroxyprogesterone use can increase the risk of developing breast cancer, heart attacks, strokes, or blood clots. Discuss with your physician the risks you face based on your personal situation.

Before you Take this Drug

This medication is for you if you have an allergy to medroxyprogesterone. Also, you suffer from:

  • Vaginal bleeding was abnormal and not examined by a doctor.
  • Liver disease
  • A background that includes heart attacks or stroke blood clots; or
  • A history of cancer related to hormones, such as breast cancer, vaginal cancer, or cancer of the uterus or cervix.

Medroxyprogesterone may cause birth defects. Avoid using it if you are expecting. Contact your doctor immediately when you discover that you're pregnant.

Medroxyprogesterone shouldn't be used to treat heart disease or stroke. It is also not recommended for dementia. It could actually raise your chances of developing the conditions mentioned above.

To ensure that medroxyprogesterone is suitable for you, inform your physician if you suffer from:

  • Heart problems
  • Liver problems
  • Asthma;
  • Migraine headaches
  • An thyroid disease;
  • Endometriosis (severe pelvic pain);
  • Jaundice resulted from pregnancies or birth medication to control;
  • Kidney disease
  • Low or high blood levels of calcium
  • A seizure;
  • The condition of diabetes
  • Lupus.

Utilizing this medicine may increase the risk of blood clots, strokes, or heart attacks, particularly when you suffer from elevated blood pressure, diabetes, elevated cholesterol, or if you're obese and/or smoke.

The long-term use of medroxyprogesterone can increase the risk of developing breast cancer in the uterus as well as in the ovaries. Consult your doctor regarding the risk.

Avoid breastfeeding.

How to Take Medroxyprogesterone?

Contact your doctor immediately when you discover that you're pregnant. Be sure to follow all instructions on your prescription label and review all drug guides or instruction sheets.

Medroxyprogesterone is typically prescribed for just a few days at a time during the month.

Regularly conduct physical exams and check your breasts for lumps every month on a daily interval while taking this medicine.

If you require major surgery or are being placed on bedrest for long periods of time, you may need to discontinue medroxyprogesterone use for a limited period of time. The medicine may affect the outcome of specific tests for medical purposes. Be sure to inform any doctor treating your condition that you're using the medicine medroxyprogesterone.

Keep at room temperature, far from heat and humidity.

Details on Dosage

Usual Adult Dose for Endometrial Hyperplasia—Prophylaxis:

Oral tablets:
5 or 10 mg daily over 12 to 14 consecutive days during the month for women who are postmenopausal, receiving daily 0.625 mg of estrogen conjugated, starting on either the first day or on the 16th day of the cycle.
Postmenopausal women with an estrogen-treated uterus  must also begin progestin therapy in order to decrease the risk of developing endometrial cancer.
Utilization of estrogen on its own or when combined with a progestin should be at the most effective dose and for the shortest duration. The dose that is started should be the most minimal.
Regularly review (e.g., at three- to six-month intervals) to see if treatment remains necessary.
If a woman has a uterus, an endometrial test should be conducted in order to exclude malignancy and instances of undetected persistent vaginal bleeding that is irregular or frequent.
Utilization: Preventing endometrial hyperplasia for postmenopausal women taking every day orally hormonal conjugated hormones (0.625 mg tablets)

Usual Adult Dose for Abnormal Uterine Bleeding:

Oral tablets:
5 mg or 10 mg per day for 5 to 10 days, beginning at the 16th or 21st day of the menstrual cycle.
Dose that produces an ideal secretory change in an endometrium that is prepared with either exogenous or exogenous estrogen. 10 mg a day for 10 consecutive days, starting on the 16th day
The bleeding that occurs during withdrawal usually happens within 3–7 days of ending treatment with tablets for oral use.
Patients with a background of repeated periods of bleeding from the uterus that is abnormal might benefit from menstrual cycles using tablets taken orally.
Treatment: unusual uterine bleeding caused by hormonal imbalances in the absence of any organic pathology like fibroids or cancer of the uterus

Usual Adult Dose for Amenorrhoea:

Oral tablets:
5 mg or 10 mg once a day over 5 to 10 days
Dosage for promoting optimal secretory change in an endometrium that has been properly stimulated by either exogenous or exogenous estrogen
10-mg daily, for a total of 10 days
Therapy can begin at any time.
It is common for withdrawal bleeding to occur between 3 and 7 days following the discontinuation of therapy with the drug.
Treatment for secondary amenorrhoea due to hormone imbalance in the absence of an organic cause, such as fibroids, uterine cancer, or other ovaries

What Happens If I Miss a Dose?

Do not take the medication as fast as possible; however, avoid taking the dose you missed when it's almost time to take your next dose. Take two doses simultaneously.

What Happens If I Overdose?

For medical emergencies, seek emergency treatment or contact the Poison Help line toll-free at 1-800-222-1222.

What Should be Avoided?

Beware of smoking when you take methylprogesterone. Smoking cigarettes greatly increases the chance of developing blood clots.

Side effects of Medroxyprogesterone

Contact a medical professional immediately. If you are experiencing indications or warning signs of an allergic response to Medroxyprogesterone, such as hives and breathing difficulties or swelling on the lips, face, tongue, or throat,

Do not take this medication and contact your physician at any time if you suffer from:

  • Indications of a stroke an abrupt numbness or weakening (especially on the affected side of your body) and a sudden extreme headache or slurred speech; difficulties with balance or vision;
  • Indications of the presence of a blood clot (sudden loss of vision and chest pain that is stabbing, experiencing shortness of breath, and coughing up blood). heat or pain in either or both legs.
  • Heart attack signs Heart attack symptoms: chest pains or tension, swelling of the shoulder or jaw, nausea, sweating
  • liver disorders: nausea and stomachache; the feeling of fatigue; fever; dark coloured stools; urine that is clay-coloured; jaundice (yellowing of the eyes or skin);
  • Vaginal bleeding that is unusual
  • Memory problems, confusion;
  • An unidentified lump in the breast;
  • Indicators for symptoms of depression, insomnia, fatigue, and mood swings.

The most common side effects of medroxyprogesterone are:

  • Spotting or bleeding in the breakthrough;
  • Changes in your menstrual cycle;
  • The vaginal area is irritated or discharges;
  • Headache, dizziness, being anxious or depressed
  • The breast or discharge,
  • Stomach discomfort, bloating, nausea, and vomiting;
  • Itching, rash, acne, and hair loss. losing hair;
  • Premenstrual-type symptoms (bloating, fluid retention, mood changes);
  • Weight gain
  • The swelling or bruising of your veins
  • Tiredness, trouble sleeping,
  • Vision changes, as well as difficulty wearing contact lenses.

This isn't an exhaustive listing of all side effects. There are other possible side effects. Contact your doctor to seek medical advice on adverse effects. The best way to report adverse reactions is to call the FDA at 1-800-FDA-1088.

Interaction with Other Drugs

Certain other medications can interfere with medroxyprogesterone. This includes medicine that is prescribed or over-the-counter, vitamins, as well as natural products. Discuss with your physician all the other medications you are taking.



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