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Annovera vaginal ring

Generic Name: Ethinyl estradiol and segesterone (vaginal ring) [ETH-in-il-es-tra-DYE-ole-and-se-JES-ter-one]
Name of The Brand: Annovera
Drug Class: Contraceptives

What is Annovera?

Annovera Vaginal Rings are made from silicone and are infused with two female hormones, which are released slowly through your vagina and later absorbed into your blood. The vaginal ring contains progesterone acetate and the hormone ethinyl estradiol.

Annovera is commonly used by women as contraception to stop the onset of pregnancy.

A single Annovera vaginal ring is able to be used again for up to one year.


Annovera is not recommended for use. Annovera if your condition is: uncontrolled high blood pressure, heart conditions, coronary artery disease, a decreased flow of blood towards your brain, chronic diabetes (or health issues due to diabetes), undiagnosed vaginal bleeding, liver disease or cancer, severe headaches in the event that you are also taking certain hepatitis C medications, or in the event that you are scheduled for major surgery, if you smoke and are older than 35 years old, or have suffered or suffered from a heart attack or stroke, blood clot, breast cancer, the uterus, cervix, or vagina

You shouldn't take Annovera if you smoke and are over 35 years old.

Do not wear an Annovera vaginal ring when you are expecting or have recently had a child.

Before You Take This Drug

Annovera is not recommended for use in the event that you are allergic to progesterone, ethinyl estradiol, 

  • Uncontrolled blood pressure that is not controlled (especially in the event that you also suffer from damaged blood vessels);

  • Heart-related problems (coronary arterial disease or heart rhythm disorder, a heart valve problem, and a history of heart attack, stroke, or blood clots);

  • Decreased blood flow to the brain

  • An increased risk of developing blood clots as a result of an issue with the heart or hereditary blood disorder

  • Diabetes (and you are older than 35 or have had diabetes for more than 20 years);

  • A health issue related to diabetes (vision issues, kidney issues) circulatory problems, nerve damage);

  • An antecedent history of hormone-related cancer as well as cancers of the breast, vagina, or uterus/cervix;

  • Abnormal vaginal bleeding that isn't being examined by the doctor;

  • Migraines or severe headaches that cause changes in vision;

  • Cancer of the liver or liver

  • If you have taken any hepatitis C medication containing ombitasvir, paritaprevir, or ritonavir in the past 2 weeks.

You shouldn't use Annovera if you smoke and are over 35 years old. Using this medicine could increase the chances of having strokes, blood clots, and heart attacks, particularly when you smoke.

To be sure Annovera is safe for you, ask your physician if you've previously had:

  • Heart disease, high blood pressure, or if you're prone to developing blood clots.

  • High cholesterol or triglycerides (a type of fat that is found in the blood);

  • Liver disease, as well as jaundice (yellowing of your eyes or skin);

  • Kidney disease;

  • Diabetic; gallbladder disease;

  • Depression, migraine headaches, or a seizure;

  • Toxic shock syndrome or vaginal irritation

  • A previous stroke in the family and an inherited history of breast cancer;

  • A lump in the breast or fibrocystic disease of the breast, or an abnormal mammogram or

  • If you've recently experienced an abortion or miscarriage. an abortion.

Use an Annovera vaginal ring when you are pregnant or if you've had a baby in the past four days. Call your doctor if you don't have a period or believe you might be expecting one.

It is not recommended to breastfeed while using Annovera.

Annovera is not recommended for women who have not yet experienced menstrual cycles or are not having menstrual periods.

How To Take  Annovera?

Take Annovera only as instructed by your doctor. Follow the directions on the label of your prescription and study all medication guides or instruction sheets.

The Annovera vaginal ring won't hinder pregnancy if it is worn only during intercourse. You must wear the ring continuously for three complete days (21 consecutive days).

Within 21 days, you can remove the ring. Wait 7 days before re-inserting the ring back in. Be sure to adhere to the timetable for inserting and then removing the rings.

Don't take the Annovera bandage out of the vagina for two hours during the 21-day wear duration.If the ring is removed, take it out and wash it using gentle soap and warm water. Wipe it dry using a soft towel, and then reinsert it.

It is possible to need alternative birth controls (condoms or spermicides, but not condoms for females) for seven consecutive days:

  • If the ring was removed from the vagina for longer than two hours in the 21-day wear time

  • If the Annovera ring has been absent from the vagina for more than 7 days,

  • If you just had a baby but aren't yet experiencing menstrual cycles again.

There is a chance that you are experiencing breakthrough bleeding. Consult your physician if this bleeding continues for more than seven days or is very heavy.

If you are in need of major surgery or are being placed on bed rest for long periods of time, you may need to discontinue using Annovera for a brief period of time. Any surgeon or doctor who treats you should be aware that you're wearing Annovera vaginal rings.Annovera does not shield against sexually transmitted illnesses, including HIV or AIDS. The use of a condom may help you protect yourself from these illnesses.

When the ring falls out of the vagina, clean the ring using moderate soap and water. dry and place it in the ring case supplied. Keep it at room temperature. Be sure to keep it away from the sun, heat, and freezing. Follow the instructions provided to clean and sanitize the Annovera vaginal ring after it has not been used.

After having used an Annovera vaginal ring for a period of one year, throw away the vaginal ring you used inside the pouch or case it came in, and then throw it away somewhere that pets and children cannot access it. Don't flush the ring into the toilet.

What happens If I Miss The Dose?

Contact your doctor. If you are off-plan or you are having difficulties removing vaginal rings,

What Happens If I Overdose?

A high dose of Annovera isn't expected to be harmful but could result in discomfort or vaginal bleeding.

What Should Be Avoided?

Don't leave the ring on for more than three weeks.Avoid using an oil-based vaginal product like a gel, cream, or suppository. It is possible to use vaginal lubricant that is water-based, but not one that contains silicone or oil.

Annovera can create dark spots on your face. Avoid sun exposure or tanning beds. Protect yourself with protective clothes and sunblock (SPF 30 or greater) whenever you're outside.

You might want to avoid taking grapefruit juice in conjunction with Annovera and other medications. Consult your physician or pharmacist.

Side Effects Of Annovera

Get immediate medical attention. If you are experiencing symptoms that indicate that you are experiencing an allergic reaction, Annovera, such as itching, breathing problems, and swelling of your lips, face, and tongue.

See your doctor right away if you are suffering from:

  • Extreme hypertension, very high blood pressure. extreme headache fuzzy vision and pounding inside your neck or ear;

  • Indications of an enlargement of blood: sudden weakness or numbness (especially for one leg) an intense and sudden headache, difficulty speaking or vision, symptoms of chest pain or feeling drained of breath, and numbness or pain in either or both legs;

  • Warning signs of heart attack symptoms include chest pain or pressure, pain that spreads into your shoulder or jaw, nausea, sweating, and vomiting.

  • Toxic shock syndrome A sudden body ache, fever, the appearance of a skin eruption, vomiting, diarrhea, and feeling lightheaded or dizzy;

  • New headaches as well as a shift in intensity, pattern, or intensity

  • Jaundice (yellowing of the eyes or skin)

  • Signs of depression, mood swings, and thoughts of harming yourself.

Some common side effects of Annovera could include:

  • Headache;

  • Nausea, vomiting, diarrhea, and stomach pain;

  • Vaginal discharge or itching

  • Menstrual discomfort; tenderness of the breasts;

  • Vaginal bleeding is irregular;

  • Burning or pain after you urinate;

This isn't a complete list of all the side effects. Other side effects could be present.

Seek advice from your doctor for medical advice about adverse effects.

You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction With Other Drugs

Certain medications can reduce the effectiveness of birth control and lead to the birth of a baby. Make sure you use a barrier version for birth control (a male condom containing spermicide but not female condoms) together with an Annovera vaginal ring when you are also using any of the following drugs:

  • Aprepitant, bosentan, and St. John's wort;

  • Antifungal medicine;

  • Antiviral medicine used to treat hepatitis C as well as HIV/AIDS;

  • Medications for blood pressure;

  • Seizure medicine;

  • Steroid medicine;

  • Thyroid medicine,

  • Tuberculosis medicine.

Use the birth control barrier until at least 28 days have passed following your last dose of these drugs.

Annovera may affect the blood levels of other medications that you take, which can cause more side effects or make the drugs less efficient. Certain drugs may affect the levels in your blood of ethinyl estradiol and progesterone if you are taking them in conjunction with grapefruit juice.

Discuss with your physician all the medicines you are currently taking and any medications you begin or stop taking. Numerous drugs can interact with Annovera, such as prescription and over-the-counter medicines, vitamins, and herbal supplements. The interactions with Annovera aren't all included here.




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