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Euflexxa (Injection)

Generic name: sodium hyaluronate (injection) [SO-de-um-HYE-al-yoo-RON-ate]
Brand names: Durolane, Euflexxa, Gel-One, Gelsyn-3, GenVisc 850,… show all 11 brands
Drug class: Viscosupplementation agents

What is Euflexxa?

Euflexxa acts as both a lubricant and shock absorber for joints. This fluid provides cushioning against osteoarthritis pain in knee joints, typically given when other arthritis medications have not proven successful; Euflexxa may also be prescribed for other purposes that aren't listed here.

Side effects of Euflexxa

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of the face, lips, or throat.

Euflexxa may cause serious side effects. If you experience:

  • After the injection, you may experience severe swelling or pain around the knee.

Some of the common side effects associated with Euflexxa include:

  • The injection site may be accompanied by pain, swelling, inflammation, redness, or stiffness.
  • Nausea, stomach pain;
  • Trouble walking
  • You may experience swelling in your hands or feet.
  • Backache, joint pain, muscular pain
  • Feeling of numbness, tingling, or a tingling sensation;
  • Headache, dizziness,
  • Sneezing or runny nose

There may be other side effects. For medical advice on side effects, call your doctor. Contact the FDA by dialing 1-800-FDA-1088 in order to report adverse side effects.


Euflexxa should not be given if there is an infection on your knee or the skin surrounding your knee.

Before you take this drug

Euflexxa should not be used if the patient is allergic to it or has an infection on their knee or around their knee.Euflexxa should not be used by anyone under the age of 21.

Tell your doctor about any of the following:

  • Blood clots in the legs or problems with circulation
  • Allergy to Birds, Feathers, or Egg Products

Euflexxa is not known to harm an unborn child. Inform your doctor if you are pregnant.You may not be able to breastfeed your baby while taking this medication. You should ask your doctor if there are any risks.

How to take Euflexxa?

Euflexxa injections can be given directly into the knee joint by a healthcare provider.Euflexxa can be taken once a week for 3-5 weeks.Make sure to heed your physician's recommendations.Your doctor may suggest that you rest your knee after the injection or apply ice to it for a few minutes.You should read all the information provided, including medication guides and instructions.If you have any concerns, consult your physician or pharmacist immediately.If your symptoms don't improve or worsen, tell your doctor.

What happens if I miss the dose?

If you miss your Euflexxa appointment, call your doctor to get instructions.

What happens if I overdose?

Overdoses are unlikely because this medication is administered by a health professional in a medical environment.

What should be avoided?

Avoid jogging or strenuous activities for at least 48 hours after the injection. This includes high-impact sports like soccer or tennis. Avoid standing or doing any weight-bearing activities for more than an hour. You should ask your doctor for the recommended time before you can resume such activities.

Interaction with other drug

Euflexxa may be affected by other drugs, such as vitamins and herbal products. Inform your doctor of all the medicines you are taking and those that you stop or start using.