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Generic Name: Paliperidone (oral) (oral) PAL-ee-PER,-i-DONE [PAL-ee-PER-iDONE]
Name of the Brand: Invega
Dosage Format: Oral tablet, extended release (1.5 mg, 3 mg, 6 mg, 9 mg)
Drug Class: Atypical antipsychotics

What is Paliperidone?

Paliperidone is an antipsychotic medication that is prescribed to manage schizophrenia in teenagers and adults who are 12 years old.

Paliperidone can also be employed for other purposes that are not covered in this medication guideline.

Side effects of Paliperidone

Seek medical attention immediately. If you are experiencing symptoms that are warning signs of an allergic reaction, such as asthma, hives, or swelling of your lips, face, and tongue,

Take paliperidone off your list and contact your doctor immediately. If you show any of the following signs of a serious disorder of movement:

  • There are shaking or tremors in your legs or arms.
  • Muscles that are not controlled within your facial muscles (chewing, lip-smacking, frowning, tongue movements, blinking, eye movements)
  • Any new or unique muscles that you can't be able to

Paliperidone may cause serious side effects. Contact your doctor immediately. If you suffer from:

  • Rapid or pounding heartbeats, a fluttering chest, shortness of breath, and sudden dizziness (like you're going to faint);
  • Breast swelling (in women or men), nipple discharge;
  • Changes in menstrual cycles;
  • Impotence; penis erection that is painful or lasts 4 hours or more;
  • Weight gain
  • Low white blood cell count Low white blood cell counts low white blood cell counts—chills, colds, skin sores, mouth ulcers the sore throat, cough, and difficulty breathing;
  • Blood sugar levels are high (increased thirst, more frequent food intake, urination, or breath odor),
  • Extreme nervous system reactions are characterized by very rigid (rigid) muscles, a high fever, rapid or pounding heartbeats, and falling asleep.

Common negative side effects of paliperidone include:

  • Drowsiness;
  • Anxiety;
  • Muscle stiffness, tremors, or shaking;
  • Muscles that are not controlled, problems in walking, balance, or speaking;
  • Weight gain
  • Upset stomach, constipation;
  • Rapid heart rate
  • Sore throat, stuffy nose

This isn't a complete list of possible side effects, and other effects may also be present. Consult your physician to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.

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Paliperidone isn't recommended for use by older adults suffering from dementia-related psychosis.

Before you take this drug

It is not recommended to use paliperidone when you have an allergy to either paliperidone or risperidone (Risperdal).Paliperidone could cause an increase in the likelihood of death for people with psychosis related to dementia. This is not recommended for this reason.

Long-term or high-dose use of paliperidone may cause serious movement disorders that might not be reversible. The longer you take paliperidone, the more likely you are to be affected, particularly if you're a female or a senior.

Inform your doctor if you were ever diagnosed with:

  • heart issues, heart disease, or heart attack;
  • The long QT disorder (in either you or family members);
  • Either high blood pressure, lower blood pressure, or fainting spells;
  • Low white blood cell (WBC) count;
  • A serious neurologic disorder that is caused by the use of an antipsychotic drug;
  • Muscles that are not controlled in your face.
  • An intestinal or stomach disorder;
  • Kidney disease or liver failure;
  • Seizures or epilepsy;
  • The presence of an imbalance in electrolytes (such as the low levels of potassium and magnesium found in blood);
  • Diabetic (paliperidone can increase blood sugar). Also known as
  • Breast cancer.

Inform your doctor if you are expecting or planning a pregnancy while taking this medication.

Antipsychotic medication taken during the last three months of pregnancy can result in breathing or feeding issues. It could also cause withdrawal symptoms in newborns. But you could experience withdrawal-related symptoms or even other issues when you stop taking the medication during pregnancy. If you get pregnant, tell your doctor right away. Don't stop taking paliperidone until you've received advice from your doctor.

If you're pregnant, then your name might be added to the pregnancy registry to monitor the effect of paliperidone on the infant.It might not be safe to breastfeed while taking this medication. Talk to your doctor about any risks.

How to take Paliperidone?

Follow the directions on your prescription label and go through all medication guides or instruction sheets. Follow the medication exactly as prescribed.

Paliperidone can be taken without or with meals.Take the tablet in one swallow and don't chew, crush, or break it.Your doctor will monitor your health frequently.Keep at room temperature, free of heat, moisture, and light.

What happens If I miss a dose?

Do not take the medicine for as long as you can. However, avoid your missed dose if it's nearing the time to take the next dose. Don't take two doses at once.

Refill your prescription prior to the expiration date of your medication.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

The symptoms of an overdose can include extreme fatigue, rapid heartbeats, and fainting.

What should be avoided?

When you take paliperidone, you could be more susceptible to temperature fluctuations. Be careful not to get too hot or become dehydrated. Take plenty of water, particularly during hot weather or when exercising. It is more likely that you'll be extremely hot and dehydrated when you're taking paliperidone.Beware of drinking alcohol. Dangerous side effects may be experienced.

Avoid driving or engaging in hazardous activities until you are aware of the effects of paliperidone. Drowsiness, dizziness, or confusion can cause accidents, falls, or serious injuries.Be careful not to get up too fast from a lying or sitting position, as you could be dizzy.

Interaction with other drugs

Paliperidone in combination with other medications that cause you to feel dizzy or lower your blood pressure may increase the severity of these effects. Talk to your doctor prior to using opioid medication, a sleep pill, a muscle relaxer, or medication to treat seizures or anxiety.

It is sometimes not safe to take certain medications together. Certain drugs may affect the blood levels of other medications that you are taking. This could create side effects or render the drugs less effective.

Paliperidone is a drug that can be affected by a variety of drugs. This includes over-the-counter and prescription drugs, vitamins, and herbal products. The interactions between these products are not included in this list. Discuss with your physician your current medications and any medications you begin or stop taking.



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