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Generic names: Doptelet (40 mg daily dose), Doptelet 60 mg daily dose
Oral tablet (20 mg)
Drug class: platelet-stimulating agents

What is Avatrombopag?

Avatrombopag treats thrombocytopenia in adults who have chronic liver diseases and are scheduled for a medical procedure.Avatrombopag can also be used to treat chronic immune thrombocytopenia if other treatments fail.Avatrombopag does not cure thrombocytopenia or bring your platelet count back to normal.This medication guide does not list all possible uses of Avatrombopag.

Side effects of Avatrombopag

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of your lips, face, tongue, or throat.

A blood clot could form while you are using Avatrombopag. If you experience:

  • Chest pain, shortness of breath
  • Fast heartbeats;
  • Pain, swelling, or redness on one or both legs
  • Stomach pain or tenderness
  • If you experience sudden fever, chills, yellowing of the skin or eyes, or a sudden fever
  • Bloody or tarry stool, vomiting blood, or vomit that looks like coffee grounds

Some of the common side effects associated with avatrombopag include:

  • Fever;
  • Purple or red spots or bruising on the skin (nosebleeds or bleeding gums);
  • Feeling tired
  • Joint pain,
  • Cold symptoms like a runny or stuffy nasal passage, sneezing, and a sore throat.
  • Nausea, stomach pain,
  • Swelling in the hands or feet

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


Please read all the instructions on the label or package of your medication. Inform your healthcare provider about your medical conditions, your allergies, and the medicines you are using.

Before you take this drug

If you have an allergy to avatrombopag, then it is best not to use it.

Tell your doctor about any of the following:

  • A blood clot
  • A bleeding or blood-clotting disorder that is not thrombocytopenia

Before you begin taking avatrombopag, your doctor will perform a blood test to measure the platelet count.This medicine is not known to harm an unborn child. Inform your doctor if you are pregnant.While using avatrombopag and for 2 weeks following your last dose, you should not breastfeed.

How to take Avatrombopag?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed.Take avatrombopag along with your food.Avatrombopag should be taken daily for chronic immune thrombocytopenia.Avatrombopag should be taken every day for five days in patients with chronic liver disease, starting 10 to 13 working days prior to the procedure. Follow your doctor's instructions regarding the timing and dosage of the medicine.To determine the length of treatment, your doctor will check your platelet counts every week. Blood tests may be required for several weeks following your last dose.Store away from moisture or heat at room temperature. Each tablet should be kept in its foil blister until you're ready to use it.

Details on dosage

Adult dose for thrombocytopenia:

Chronic liver disease
If your platelet count is less than 40x10(9)/L, you should take 60mg orally every day for 10 to 13 days before the procedure.
If your platelet count is between 40 and 50 x 10(9)/L, take 40 mg once daily, starting 10 to 14 days before the procedure.
Duration: 5 days
Patients should have their procedure performed 5 to 8 days after taking the last dose.
Do not use this medication to normalise your platelet count.
Use: To treat thrombocytopenia among patients with chronic liver diseases who are undergoing a surgical procedure.
Chronic immune thrombocytopenia
Initial dose: Orally, 20 mg once daily with food
Maximum dose: 40 mg/day
Use the lowest dose necessary to achieve and maintain platelet counts greater than or equal to 50 x 10(9)/L, as needed to reduce bleeding risk.
Do not use this medication to normalise your platelet count.
Use: Treatment for thrombocytopenia among patients with chronic immune-thrombocytopenia who have not responded to previous treatments.

What happens if I miss the dose?

If you have chronic immune thrombocytopenia, take the missed dose as quickly as possible. Continue to take your daily dose and your next dosage at the same time. Take no more than one dose at a time.Before any scheduled medical procedure, call your doctor to get instructions.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Aviod this

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Interaction with other drug

Other drugs, such as vitamins and herbal products, may also affect avatrombopag. Inform your doctor of all the medicines you are taking and those that you stop or start using.




Prescription only

Pregnancy & Lactation

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