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Invokamet

Generic name: Metformin [ KAN-a-gli-FLOE-zin-and-met-FOR-min ]
Names of brands: Invokamet, Invokamet XR
The class of drug: Antidiabetic combinations

What is Invokamet?

Invokamet includes a mix of canagliflozin and metformin. Canagliflozin, along with metformin, are both oral diabetes medications that aid in controlling blood sugar levels. Invokamet is combined with exercise and diet to improve blood sugar control for people suffering from type 2 diabetes mellitus. Invokamet can also be used to reduce the risk of dying caused by coronary heart attacks, strokes, heart attacks, and the failure of the heart in adults suffering from Type 2 diabetes who suffer from heart disease. Invokamet also helps decrease the risk of end-stage kidney disease, death, or hospitalization due to heart problems for people who have kidney problems due to type 2 diabetes. This medication is not to treat type 1 diabetes.

Warnings

You shouldn't make use of Invokamet in the case of an extreme kidney condition or diabetic ketoacidosis. Canagliflozin could increase your chance of having your lower leg amputated, particularly if you've previously had an amputation, a foot ulcer, a heart condition, or circulation problems, as well as nerve injuries.

Canagliflozin can trigger serious infections of the vagina or penis. Get medical help immediately if you notice irritation, burning, odor, or discharge, pain or swelling, redness or tenderness of the rectal or genital region, fever, or if you're not feeling well.

Invokamet can cause a severe health condition known as lactic acidosis, which is a serious buildup of lactic acids within your blood. Consult your physician or seek emergency medical attention in the event of strange muscle pains, difficulty breathing, stomach pain, dizziness, feeling cold, or feeling tired or weak.

Before you Take this Drug

It is not recommended to use Invokamet in the event that you are allergic to metformin or canagliflozin or if you suffer from:

  • Severe kidney disease severe kidney disease
  • Ketoacidosis (call your doctor to seek treatment).

If you require any kind of x-ray or CT scan that uses the injection of a dye into the veins of your body, you might require a temporary stop to taking Invokamet.

To be sure Invokamet is appropriate for you, consult your physician if you suffer from:

  • Heart issues
  • A diabetic foot ulcer or amputation
  • Nerve problems or circulation issues in your feet or legs
  • Kidney or liver disease
  • Low concentrations of vitamin B12 or calcium are present in your blood.
  • Bladder infections or other urinary issues
  • A pancreas-related disorder or surgery
  • A change in your diet
  • If you're on an eating plan that is low in salt

It is possible to suffer from an illness called lactic acidosis. This is an extremely dangerous accumulation of lactic acid in your blood. This is likely if you have any other medical issues, a severe illness, chronic alcoholism, or are older than 65. Talk to your doctor regarding your danger. Talk to your doctor immediately if you are pregnant. Canagliflozin may harm the unborn baby if you are taking Invokamet during the third or second trimester.

Metformin can stimulate ovulation in premenopausal women and increase the chance of an unintended pregnancy. Discuss with your physician your potential risk. It is not recommended to breastfeed while using this medication. Invokamet is not a product that has been approved to be used by anyone less than 18 years of age.

How to take Invokamet?

Use Invokamet exactly as directed by your physician. Follow the directions on the prescription label and review all medication manuals or instruction sheets. Your doctor may modify your dosage. If you've been taking metformin extended-release tablets in the evening, skip the final dose that evening before you begin taking Invokamet. Use this medicine in conjunction with food. mSuck this tablet with extended release in its entirety, but do not crush, chew, or break it.

It is possible to be suffering from lower levels of blood sugar (hypoglycemia), and you may feel hungry and dizzy, as well as irritable and anxious. You may also feel confused, disoriented, or shakey. To speedily cure hypoglycemia, take a snack or drink a quick-acting source of sugar (fruit juice crackers, hard candy raisins, or other non-diet drinks). Your physician may recommend the use of a glucose injection kit if you suffer from severe hypoglycemia. Make sure that your family members or your closest friends know how to administer the injection in the event of an emergency. mAlso, look out for symptoms of excessive glucose levels (hyperglycemia), like increased thirst or increased urination.

The levels of blood sugar are altered due to stress or illness, surgical procedures, exercise, drinking, or eating infrequently. Talk to your doctor prior to making changes to your medication or dosage schedule.

Your physician may recommend that you take additional vitamin B12. You should only take the amount of vitamin B12 prescribed by your physician. Advised. Contact your doctor if you are suffering from persistent nausea and/or diarrhea or are sweating more than normal. You could easily get dehydrated when you take Invokamet, and this can cause severely reduced blood pressure or a severe electrolyte imbalance.

If you are in need of medical or surgical procedures, inform any physician who sees patients that you're using Invokamet. You might need to stop the medication at least three days prior to the date of the procedure. Discuss with your doctor how to manage your blood sugar level during this period. Invokamet is just one component of a treatment program that may include exercise, diet, control of weight, blood sugar tests, and medical treatment. Follow your doctor's advice precisely. mKeep tablets in the original container in a cool, dry place away from heat and moisture. Don't keep tablets of Invokamet within a day-to-day pill container for more than 30 consecutive days.

Details on Dosage

Usual Adult Dose for Diabetes Type 2:

Initial dose: 100 mg taken orally every day, once
It is possible to increase the dose to 300 mg once every day for further glycemic management in patients who have a good response to treatment and are able to maintain an EGR of mL/min/1.73 or more.
Maximum dose: 300 mg/day

Comments:
Check renal function prior to starting treatment; discuss with the doctor dose adjustments in patients with eGFR less than 60 mL/min/1.73 2.
Normalize the volume before beginning therapy.
If used in conjunction with insulin or an insulin-secretagogue, the use of a lower dose of insulin as well as the secretagogue insulin needs to be considered in order to decrease the chance of developing hypoglycemia.

Uses:
As an addition to exercise and diet, it can improve the glycemic balance of patients suffering from type 2 diabetes mellitus.
To reduce the risk of serious heart events (cardiovascular death as well as nonfatal myocardial ischemia or nonfatal stroke) for adults suffering from the type 2 form of diabetes as well as existing cardiovascular disease.
To decrease the risk of kidney disease, double the amount of serum creatinine levels, cardiovascular deaths, and hospitalization due to heart failure among adults suffering from the type 2 form of diabetes as well as diabetic nephropathy that has albuminuria higher than 300 mg/day.

Usual Adult Dose for Cardiovascular Risk Reduction:

Initial dose: 100 mg taken orally every day, once
It is possible to increase the dose to 300 mg taken orally every day for further glycemic control for patients who have tolerated treatment and possess an estimated glycemic response of mL/min/1.73 m2 or higher.
Maximum dose: 300 mg/day

Comments:
Assess renal function prior to starting treatment; discuss with the doctor dose adjustments in patients with an eGFR of less than 60 mL/min/1.73 meters2.
Check the status of your volume prior to initiating therapy.
If used in conjunction with insulin or an insulin-secretagogue, an insulin dose that is lower as well as the secretagogue insulin needs to be considered to lower the risk of hypoglycemia.

Uses:
As an aid to exercise and diet, it can increase glycemic control for those suffering from type 2 diabetes mellitus.
To decrease the risk of serious negative cardiovascular incidents (cardiovascular death as well as nonfatal myocardial ischemia and nonfatal stroke) in people who have Type 2 Diabetes Mellitus as well as already diagnosed cardiovascular disease.
To decrease the risk of kidney disease, the doubling of serum creatinine levels, cardiovascular deaths, and hospitalization due to heart failure among adults suffering from Type 2 Diabetes Mellitus as well as diabetic nephropathy characterized by albuminuria of more than 300 mg/day

What Happens If I Miss a Dose?

Do the medication (with food) whenever you can, but do not skip your missed dose in case it's nearing the time to take the next dose. Don't take two doses at once.

What Happens If I Overdose?

You should seek medical attention in an emergency or contact the Poison Helpline at 1-800-222-1222. There is a possibility that you are suffering from a severe drop in blood sugar levels (extreme weakness, nausea, sweating, tremors, difficulty speaking, rapid heartbeats, or seizures).

What Should be Avoided?

Do not drink alcohol. It can lower blood sugar levels and increase the chance of developing lactic acidosis.

Side Effects of Invokamet

See a doctor immediately in the event that you exhibit symptoms of an allergy reaction. Invokamet: hives, breathing problems, or swelling of your lips, face, or tongue.

You should seek medical attention immediately if you notice symptoms of a genital illness (penis or vagina): burning, itching, and odor, as well as discharge, pain, tenderness, swelling, or redness in the rectal or genital region or rectal area, fever, or not feeling well. These symptoms could worsen quickly.

Mild signs of lactic acidosis can get worse as time passes and could lead to death. Take a break from Invokamet and consult your physician immediately if you notice strange muscle pains, difficulty breathing, stomach pain, vomiting or diarrhea, an irregular heartbeat, nausea, dizziness, or feeling fatigued or weak.

See your doctor right away. If you are suffering from:

  • New tenderness, pain, tenderness, ulcers, sores, or infections of your feet or legs;
  • Minimal or no urination
  • A lightheaded sensation, similar to passing out;
  • High potassium levels The symptoms include a feeling of weakness, nausea, the sensation of tingling, and chest pain, as well as abnormal heartbeats and muscle weakness.
  • Ketoacidosis (too much acid in the blood) It can cause nausea and stomach pain, vomiting, disorientation, unusual drowsiness, or difficulty breathing.
  • Symptoms of a urinary tract infection: burning or pain whenever you go to the bathroom or urinate that looks dark, discomfort in your pelvis or in the back.

Adults who are older are more likely to be dehydrated or develop kidney problems when taking this medication. It is possible to break a bone while taking this medication. Discuss with your physician ways to reduce the chance of breaking your bones.

Common Invokamet adverse reactions could be:

  • Urinating
  • Headache
  • Weakness
  • Gas
  • Stomach pain
  • Indigestion
  • Nausea,
  • Vomiting,

This isn't a complete list of possible side effects, and other side effects could occur. Contact your doctor for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with Other Drugs

Inform your doctor about any other medications you take, including:

  • Digoxin (digitalis, lanoxin);
  • A diuretic "water pill";
  • Insulin or other diabetes medication taken orally;
  • Rifampin
  • Ritonavir
  • Phenobarbital and phenytoin.

This list is not comprehensive. Other medications may be incompatible with metformin and canagliflozin, which include prescription and over-the-counter drugs, vitamins, and herbal products. There are many possible interactions between drugs, which are listed here.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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