What is Histrelin?
Histrelin stimulates the body's production of specific hormones and causes the production to stop temporarily. Supprelin LA, the Supprelin version of the histrelin brand, can be employed to address precocious puberty in male as well as female kids who are at least two years old. There is a Vantas version of the drug histrelin that can be used to manage the signs that are associated with prostate cancer in males. Vantas addresses only those symptoms associated with prostate cancer, but it doesn't treat the cancer itself. Histrelin is also used for reasons not mentioned in this guideline.
Side effects of Histrelin
Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, tongue, throat, or face.
Histrelin could cause severe adverse effects. Contact your doctor immediately if you suffer from:
- The sensation of numbness, bone pain, and weakness in the feet or legs;
- Uncomfortable or painful urination; blood stains in your urine;
- A seizure;
- An increase in pressure within the skull, causing severe headaches, ringing in the ears, dizziness, nausea, vision issues, or eye pain
- Mental issues, such as crying spells, anger, and feeling irritable or restless.
Common side effects of histrelin include:
- Constipation;
- Problems with urination;
- Breast swelling;
- Hot flashes;
- Fatigue;
- Erectile malfunction (impotence) or a smaller size of the testicle or
- Bleeding, redness, pain, swelling, pain, or irritation at the site where the implant was placed.
This isn't a complete list of possible side effects, and other effects may also be experienced. Consult your physician for advice regarding medical effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.
Similar/related drugs
Estradiol, Tamoxifen, Premarin, Xtandi, Zytiga, Casodex, and Leuprolide
Warnings
Histrelin could cause harm to an unborn baby or cause a miscarriage. Do not use it if you are expecting. Histrelin can trigger side effects such as angry spells, crying, and aggression, as well as being irritable or restless. Contact your doctor if you are experiencing any new or aggravating mental issues.
Before you take this drug
You shouldn't be treated with histrelin in the event that you are allergic to histrelin or similar hormones such as leuprolide and nafarelin. ganirelix, Eligard, Lupron, Viadur, and others.
Do not take histrelin if you are expecting. It could harm the unborn baby or trigger an unplanned miscarriage. Utilize effective contraception to avoid pregnancy. Also, inform your doctor immediately when you find yourself pregnant.
Vantas are not recommended for children or women.
To ensure that you are sure that the drug Supprelin LA is safe for you, ask your physician if you've previously had:
- The mental illness, also known as schizophrenia;
- Epilepsy or any other seizure disorder
- A blood vessel or tumor in your brain
- If you are taking a medication that could trigger seizures (such as an antidepressant),
To ensure that Vantas is suitable for you, ask your doctor if you've previously had:
- A bladder obstruction or any other urinary issues;
- Diabetes;
- Heart issues, heart attack, and stroke;
- The long QT disorder (in either you or a relative);
- Low bone mineral density (osteoporosis) low bone mineral density (osteoporosis)
- A condition affecting your spine.
It might not be safe to breastfeed while taking this medication. Talk to your doctor regarding any risks. Supprelin is not recommended for use by a child younger than 2 years. Vantas has not been allowed to be used by anyone younger than 18.
How to take Histrelin?
Histrelin is available as an implant that is tiny and placed under the skin inside the upper arm. It is implanted by minor surgery at a doctor's clinic or office.
It is best to put the implant inside the arm that is not your dominant arm (your left arm, if you prefer right-handed). Make sure to inform your physician which arm you use the most often.
The upper arm is treated using a numbing medication to prevent your arm from experiencing pain while the implant is being inserted. Your doctor will utilize scalpels to make an incision small enough where implants will be placed.
The histrelin implant is placed by using a specially designed tool that places the implant through the cut in the skin. Once the implant is injected and the tool used to insert it is removed, the doctor will examine your arm to make sure that the implant was properly put in place.
The skin incision could be closed using surgical strips or stitches. Follow the instructions of your physician for treating the incision, and keep it covered and clean until the wound heals completely. Maintain your arm's dryness for at least 24 hours.
Most likely, you'll be in a position to feel the implant under the skin, but it shouldn't cause discomfort or pain.
Contact your physician if you are experiencing any swelling, pain, tenderness, itching, tingling, or redness at the site in the area where the implant was put, as well as if your implant slips through your skin or disappears.
An implant made of histrelin is typically kept in place for a period of 12 months, and after that, it must be removed surgically using an incision. Don't attempt to remove the device on your own. Your doctor will decide if you require another implant as an ongoing treatment.
You might experience a temporary rise in precocious puberty signs for about a week following Supprelin LA. Supprelin LA implant
You might require medical tests to assist your doctor in determining what time frame to treat you with histrelin.
Histrelin may cause abnormal results when testing for certain medical conditions. Inform any physician who treats you to inform them that you are taking histrelin.
Details on dosage
Usual Adult Dose for Prostate Cancer:
VANTAS:
One 50 mg tablet is inserted subcutaneously into the inside of the upper arm.
The duration of treatment The implant must be removed after 12 months.
Note: The implant was designed to provide a few weeks of additional drug release, allowing for the adjustment of appointments with doctors. When an implant is removed, an additional implant can be inserted to maintain treatment.
Use Vantas as a palliative treatment for prostate cancer that is advanced.
Usual Pediatric Dose for Precocious Puberty:
SUPPRELIN LA:
2 years old and over:
One 50-mg capsule is placed subcutaneously into the inside of the upper arm.
Treatment duration The implant must be removed at the end of 12 months.
Note: If implants are removed, a new implant can be inserted for continued therapy.
Comments:
Discontinuation of treatment should be a possibility according to the wishes of the doctor and at the right time when the age at which puberty begins (approximately eleven years in females and twelve years for men).
Use:
Supprelin LA: Therapy for Children Suffering from Central Precocious Puberty
Do I be concerned if I miss a dose?
Since histrelin can be given in the form of an implant, it will not follow a daily dose schedule.
The implant shouldn't be kept in your arm for more than 12 months. Consult your physician to inform them that it is time for the implant to come out.
What will happen if I take excessively?
Because the histrelin implant has an exact amount of medication, you aren't likely to suffer from an overdose.
What should be avoided?
At least seven days after the implant has been implanted, you should avoid vigorous exercises or heavy lifting.
Interaction with other drugs
Other medications may impact histrelin, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor all your medications currently used, as well as any medications you are about to start or stop taking.
