The Web Health



Name of the generic: brodalumab broe-DAL-ue -mab [ broe-DAL’-ue’-mab
Drug class: interleukin inhibitors

What is Siliq?

Siliq is an antigen monoclonal that blocks specific proteins within the body that may cause inflammation as well as other immune responses.Siliq is a treatment for mild-to-extreme plaque psoriasis that is severe to moderate for adults. It is typically prescribed after other psoriasis treatments have been tried but with no success.

Siliq is only available from an accredited pharmacy that is part of the special program known as Siliq REMS. It is necessary to be enrolled in the program and be aware of the potential risks and benefits of using this medication.


Certain people are contemplating suicide when taking Siliq. Keep an eye on fluctuations in mood or signs. Be sure to report any symptoms that are getting worse or more severe to your physician for mood fluctuations, anxiety, or depression.

Brodalumab can affect the immune system. It can cause infections more frequently. Call your doctor when you experience symptoms like colds, fever, skin sores, cough, diarrhea, stomach cramps, or burning urine.

Prior to use this drug

It is not recommended to make use of Siliq in the event that you suffer from Crohn's disease.

To ensure that Siliq is appropriate for you, speak to your doctor if you suffer from:

  • An active or chronic illness;
  • Tuberculosis
  • Depression, anxiety mental illness, anxiety, depression, anxiety, mental illness, or a

Inform your doctor if you have ever suffered from tuberculosis or if someone within your household is suffering from tuberculosis. Tell your doctor if you have recently been on a trip. Tuberculosis is more frequent in certain regions around the globe, and you could be exposed while traveling.Consult your physician if you are breastfeeding or pregnant.Siliq is not a product that is approved for use by anyone less than 18 years old.

How to take Siliq?

Utilize Siliq exactly as directed by your physician. Adhere to all instructions listed on your prescription label and review all medication guides and instruction sheets.Siliq is injected underneath the skin. The healthcare professional may instruct you on how to use the drug yourself.Siliq is typically given every week for three weeks, then every two weeks after that. Follow your doctor's instructions for dosing.

Take note of and follow the instructions for use that come along with your medication. Talk to your pharmacist or doctor for clarification if you aren't sure about the instructions.Make an injection only when you are prepared to administer it. Don't use any medicine that appears cloudy, changes color, or has particles. Consult your pharmacist about the latest medication.

Storage of prefilled syringes should be in their original containers within the fridge. Keep them away from light, and do not shake or freeze the medication.Remove the medicine from the refrigerator and allow it to be at room temperature for 30 minutes before injecting the dose. Do not heat the medication in the microwave or put it in hot water. Place the needle cap back in place as the medicine gets warm to room temperature.

You can keep a syringe that has been filled in the container it came from at room temperature for up to 14 days. Keep it away from light and heat.Any syringe that has been heated to room temperature shouldn't be put back in the refrigerator.Each prefilled syringe can be used only once. Dispose of it after one time, even if there's still a little medicine in it.

Make use of a needle and the syringe once only, and place them into the puncture proof "sharps" container. Be sure to follow the laws of your state or city on how to dispose of the container. Make sure it is out of reach of pets and children.Brodalumab alters the immune system. It can cause infections more often, including deadly or life-threatening infections. Your doctor should check your health on a regular basis.It can take as long as 16 weeks before symptoms begin to improve. Continue to take the medication according to instructions, and notify your physician if you persist within 12 weeks after taking Siliq.

Details on dosage

Usual Adult Dose for Plaque Psoriasis:

Subcutaneously, 210 mg during weeks 0, 1, and 2, followed by 210 mg subcutaneously every 2 weeks
A continuation of treatment after 16 weeks for patients who haven't achieved an adequate response isn't likely to bring more success.
Examine those with tuberculosis (TB) infection prior to starting treatment.
Use: To treat severe to moderate plaque psoriasis in adults that are suitable for phototherapy or systemic therapy and haven't been able to respond or lose response to other treatments systemically.

What happens if I miss the dose?

Utilize the medication as soon as you are able, but do not miss any missed doses if it's close to the time for the next dose. Do not take two doses in one go.

What happens if I overdose?

For medical emergencies, seek immediate medical care or contact the Poison Help Line at 1-800-222-1222 for assistance.

What should be avoided?

Beware of injecting Siliq on skin that has been bruised or tender or on skin that is affected by plaques of psoriatic arthritis (red, thick, dense, or with the appearance of scaly).

Do not get a "live" vaccine while using brodalumab. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and the nasal flu (influenza) vaccine.

Side effects of Siliq

See a doctor immediately. If you are experiencing symptoms of an allergy reaction, Siliq: hives, breathing difficulties, and swelling of your lips, face, or tongue.

Siliq is accompanied by a medication guide and a patient wallet card listing symptoms of an adverse reaction. Learn from this guideline what symptoms to be aware of. Keep the wallet card close to you always.

Contact your doctor immediately. If you are suffering from:

  • Fever, chills, sweating, tiredness;
  • Sore throat, cough, trouble swallowing or breathing
  • Skin sores that cause warmth or redness;
  • Stomach cramps, nausea, and constipation;
  • Painful diarrhea, bloody stools, weight loss;
  • An increase in urination, pain, or burning sensation when you pee;
  • Strange changes in behavior or mood;
  • Suicidal thoughts
  • Anxiety that is new or getting worse, or depression

Common Siliq adverse effects could include:

  • Fever, chills, flu-like symptoms;
  • Itching, skin redness
  • Joint or muscle pain;
  • Nausea, diarrhea;
  • Headache, tiredness;
  • Mouth pain
  • Bleeding, redness, pain, bleeding, itching, or pain in the area where the medicine was injected.

This is not a comprehensive list of possible side effects, and others could happen. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications may be incompatible with brodalumab, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about your current medications and any medication you begin or stop taking.