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Amphotericin B

Genric Name: amphotericin-B am -foeTER-i-sin am -foe-TER-i-sin
Brand names: Fungizone, Fungizone for Tissue Culture, Amphocin
Dosage format: intravenous powder for injection (50 mg)
Drug class: polyenes

What is Amphotericin B?

Amphotericin B is an antifungal medicine that combats the occurrence of infections due to the fungus.AmphotericinB is used for treating serious, life-threatening fungal infections that could be life-threatening. It should not be used for treating mild yeast infections like those of the mouth, oesophagus, or vagina.Amphotericin B can also be used to treat conditions not covered in this medication guideline.

Side effects of Amphotericin B

Take immediate medical care in the event that you exhibit symptoms that indicate reactions to an allergen, such as hives, wheezing or breathing difficulties, and swelling of your lips, face, and tongue.

Amphotericin B may cause serious side effects. Consult your doctor immediately if you suffer from:

  • Pale skin, no bleeding;
  • The presence of blood in your stool;
  • A lightheaded sensation, similar to what you're passing out;
  • Seizure (convulsions);
  • Jaundice (yellowing of the eyes or skin);
  • The buildup of fluids within your lungs—stress, sweating at the thought of breathing, coughing with foamy mucus, chest pain, rapid or irregular heart rate
  • Indications of a kidney issue: low or no urination or difficult or painful urination; swelling on your ankles and feet; being tired or sluggish;
  • Low potassium—confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness, or limp feeling; or
  • Indications of a new infection symptoms of a new infection: symptoms of a new infection include fever, chills, and flu Signs of a new infection include mouth or throat ulcers. Quick and slow breathing.

Common adverse effects of amphotericin B could include:

  • Nausea, vomiting, stomach pain, diarrhoea;
  • An upset stomach and loss of appetite;
  • Muscles or joint discomfort;
  • Headache that is hearing ringing in your ears
  • Bleeding, pain, or swelling at the site where the medicine was injected;
  • Weight loss;
  • Flushing (warmth, redness, warmth or tingly sensation).


Amphotericin B is used to treat serious, life-threatening fungal infections that can be life-threatening. It's not recommended for treating minor fungal infections (yeast infections) that affect the mouth, oesophagus, or vagina.Avoid using amphotericin B in higher doses than the recommended amount. An overdose can cause death.

Before you take this drug

It is recommended not to receive this medication if you're intolerant to any form that contains amphotericin B (Abelcet, AmBisome, Amphocin, Amphotec, or Fungizone).

To ensure that amphotericin B is safe for you, inform your doctor if:

  • Heart disease;
  • Diabetes;
  • Kidney disease;
  • An electrolyte imbalance (such as low concentrations of magnesium, potassium, or magnesium in the blood);
  • If you're receiving blood transfusions,
  • If you're receiving radiation treatment,

Amphotericin B isn't expected to harm the unborn baby. Inform your doctor if you are pregnant or intend to become pregnant while receiving treatment.It is unclear if amphotericin B is absorbed into the milk of breastfeeding mothers or if it harms the nursing infant. While taking this medication, breastfeeding must not occur.

How to take Amphotericin B?

Amphotericin B can be injected directly into veins via an IV. The healthcare professional will give the injection.The medication must be administered slowly, via an IV infusion. It can take anywhere from 2 to 6 hours for the entire process to be complete.Inform your doctor that you are experiencing any pain, burning, or pain around your IV needle during the time amphotericin-B is being injected.Amphotericin B could need to be administered for several months or even weeks, depending on the condition being treated.If you are receiving amphotericin B, you could require regular blood tests.Utilise amphotericin B for the entire prescribed duration. Your symptoms could worsen before the infection is completely gone. The absence of doses can increase the chance of developing a new infection that is intolerant of antifungal medication. Amphotericin B is not a treatment for the symptoms of a viral disease like the flu or the commonly occurring cold or flu.

What happens if I miss the dose?

Consult your physician for the appropriate treatment. If you do not make an appointment to receive the amphotericin B injection,

What happens if I overdose?

Get medical attention immediately, or contact us for help at the Poison Help Line at 1-800-222-1222. An excessive dose of amphotericin B can cause death.

What should be avoided?

Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Other medications can interfere with amphotericin B, which includes prescription and over-the-counter medicines, vitamins, and herbal products. Inform your health professionals about the medicines you are taking now and any medication that you decide to stop or change your use of.