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Sumatriptan (injection)

Generic name: Sumatriptan (injection) [SOO-ma-TRIP-tan]
Brand names: Imitrex, Imitrex Statdose, Imitrex Statdose Refill, SUMAtriptan Succinate Syringe, Zembrace SymTouch
Dosage form: subcutaneous solution (3 mg/0.5 mL; 4 mg/0.5 mL; 6 mg/0.5 mL)
Drug class: Antimigraine agents

What is Sumatriptan injection?

Sumatriptan is a headache medicine that reduces the blood vessels that surround the brain. Sumatriptan also decreases the amount of substances within the body that cause headaches, nausea, sensitization to sound and light, and other migraine-related symptoms. Sumatriptan can be used to treat migraines as well as cluster headaches in adults. Sumatriptan can only treat headaches. Sumatriptan cannot prevent headaches or reduce the frequency of attacks. Sumatriptan is not recommended to treat commonly occurring tension headaches or headaches that cause loss of motion on the opposite side of your body. Take this medication only when your condition is confirmed by a physician in the form of migraine headaches. Sumatriptan can be used for reasons not covered in this medication guide.

Side effects of Sumatriptan Injection

Get medical assistance immediately. If you notice symptoms of an allergic reaction, such as asthma, hives, or swelling of your lips, face, and tongue, Sumatriptan may cause serious side effects. Stop taking sumatriptan immediately and contact your doctor immediately if you experience:

  • Acute stomach pains, severe stomach pain, and bloody diarrhea;
  • Intense chest pain, shortness of breath, irregular heartbeats,
  • A seizure (convulsions);
  • Blood circulation issues in your feet or legs: cramps, tightness or heavy feeling, tingling or numbness, muscle weakness, burning pain cold sensation, changes in color (pale or blue) hip pain;
  • Heart attack symptoms: chest pressure or pain; pain that spreads to your shoulder or jaw; nausea; sweating;
  • Serotonin levels are high in the body, causing hallucinations, agitation, and fever, a rapid heart rate, hyperactive reflexes, nausea, vomiting, loss of coordination, diarrhea, and fainting.
  • High blood pressure, causing severe headaches blurred vision or a pounding sensation in your neck and ears, anxiety, nosebleeds, or
  • Indications of signs of a stroke—sudden weakness or numbness (especially for one side of the body) as well as a sudden, severe headache and slurred speech, or problems with balance or vision.

Common adverse effects of sumatriptan could include:

  • Tingling, numbness, or burning sensation
  • You feel a sense of pressure or discomfort anywhere on your body.
  • Dizziness, drowsiness, feeling tired or weak;
  • Stiffness, neck pain, or
  • Redness or pain in the area at the site of the injection.

This is not an all-inclusive list of possible side effects, and other side effects could occur. Contact your doctor to seek medical advice regarding adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


You should not use sumatriptan if you have ever had heart disease, coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, a heart attack or stroke or stroke, or if your headache appears to be distinct from the usual migraine headaches. Do not use sumatriptan if you've used an MAO inhibitor in the last 14 days, like linezolid, isocarboxazid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Do not take sumatriptan for more than 24 hours prior to or after using a different migraine medication.

Before taking this medicine

Sumatriptan is not recommended if you have an allergy to it, if you suffer from a headache that appears different from your normal migraines, or if you have ever suffered from:

  • Heart conditions or stroke (including "mini-stroke");
  • Coronary arterial disease, angina (chest pain), blood circulation issues in the heart, and insufficient blood supply to the heart
  • Circulation problems affecting your legs, arms, stomach, intestines, or kidneys;
  • A heart disorder called wolff-parkinson-white syndrome;
  • Uncontrolled high blood pressure or
  • Severe liver disease that is severe

Do not take sumatriptan if you have taken an MAO inhibitor within the past 14 days. A risky drug interaction may occur. MAO inhibitors are isocarboxazid, linezolid, Methylene Blue injection, rasagiline, phenelzine, and tranylcypromine, among others.

Speak to your doctor if you have ever been diagnosed with:

  • Kidney or liver disease;
  • Epilepsy or any other seizure disorder
  • High blood pressure, a heart rhythm disorder, or
  • Risk factors for developing coronary artery disease (such as being menopausal, having diabetes, smoking, being overweight, having high blood cholesterol or pressure, having an ancestral history of coronary artery disease, having a higher age than 40, and being male)

It isn't known if this medicine could cause harm to a newborn baby. Inform your doctor if you are expecting or planning to get pregnant.

Sumatriptan may be absorbed into the milk of the breast. Do not breastfeed within 12 hours after taking sumatriptan. If you use an infant pump during this time, dispose of any milk you have collected. Do not give it to your child. Sumatriptan injection isn't recommended for use by individuals less than 18 years of age.

How to take Sumatriptan injections?

Take sumatriptan as soon as you notice headache-related symptoms. Follow all instructions on the prescription label and read the medication guide or instructions sheets. Follow the medication exactly as prescribed. doctor if the medicine isn't working properly when treating migraine attacks. Sumatriptan injections are administered under the skin. A medical professional may show you how to apply the medication yourself. Sumatriptan comes in a vial (bottle) with a needle-free injector device or a cartridge that is prefilled for an auto-injector syringe. Each type is intended for one usage only.

Take note of and follow the instructions for use that are included in your medication. Do not take sumatriptan if you aren't familiar with all the instructions for proper use. Consult your doctor or pharmacist if you have any questions.

Make sure to prepare your injection once you're prepared to administer it. Don't use a vial when the medicine appears cloudy, has changed colors, or contains particles. Contact your pharmacist to inquire about new medications. Following an injection: If you experience headaches and they aren't gone completely, consult your physician prior to giving an additional injection. If your headache is gone and then returns after a second injection, you should use it when it's been at least an hour since your initial injection. Do not apply more than two injections in the space of 24 hours. Call your doctor when your symptoms do not improve. Keep the medicine at room temperature, free of heat, moisture, and light. Discard any medicine that is not used after the expiration date on the label is over. Use a syringe and needle only once, and then put the items in a puncture-proof "sharps" container. Be sure to follow the laws of your state or city on the disposal of the container. Make sure it is out of reach of pets and children.

What happens If I miss a dose?

Because sumatriptan can be used only as needed and is not a prescription drug, it doesn't have a regular dosing schedule. Consult your physician if your symptoms do not improve after taking this medication.

What happens if I overdose?

Seek medical attention in an emergency situation or contact the Poison Helpline at 1-800-222-1222.

Overdose symptoms can include tremors and skin redness in your legs or arms, weakness in coordination, breathing difficulties, blue-colored lips or fingernails, vision problems, or seizures (convulsions).

What should be avoided?

Do not take sumatriptan for 24 hours prior to or after using a different migraine medication, such as:

  • Sumatriptan tablets, nasal sprays, almotriptan, eletriptan, frovatriptan, naratriptan, zolmitriptan, or
  • Ergot medicine such as dihydroergotamine, ergotamine, ergonovine, or methylergonovine.

Avoid driving or engaging in hazardous activities until you are aware of how sumatriptan affects you. Your reactions may be affected.

Interaction with other drugs

Sumatriptan, when taken with other medications, can result in excessive levels of serotonin accumulating inside your body. This condition is referred to as "serotonin syndrome," which could be fatal. Consult your physician if you also take:

  • Medication used to treat depression or a psychiatric condition;
  • Medicine to treat the disease Parkinson's;
  • Medicines to treat serious infections.
  • Herbs;
  • Stimulant medicine
  • Opioid medicine, or
  • Medicine to stop vomiting and nausea

This list isn't comprehensive. Other medications can affect sumatriptan, such as prescription and over-the-counter medications, vitamins, and herbal products. There are many possible drug interactions. are listed here.



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