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Edurant

Name of the generic: rilpivirine RIL-pi-VIR-een RIL-pi-VIR [RIL-pi-VIR-een]
Drug class: NNRTIs

What is Edurant?

Edurant is an antiviral medication that stops the human immunodeficiency virus (HIV) from multiplying throughout your body.Edurant is utilized in conjunction with other antiviral medications in order to cure HIV. Edurant is a treatment for children and adults over 12 years old who weigh a minimum of 77 pounds (35 kg), have never used any HIV medication, and are carrying a high level of the virus in their blood (this is known as "viral load") that is less than 100,000 copies/mL. The Edurant test is not an effective treatment for HIV and AIDS.Edurant may be combined with cabotegravir to provide an everyday "lead-in dose" to help decide if you are able to make use of a combination of these drugs as an injection every month. Edurant and cabotegravir could also be administered in the short-term instead of in a month-long injectable mix for a period of up to 2 months. For these reasons, Edurant is not recommended for those who suffer from HIV and have tried other antiviral drugs that have lowered their viral burden.

Side effects of Edurant

See a doctor immediately when you are experiencing symptoms warnings of an E-inflammation reaction (hives and breathing difficulties or a swelling in your throat or face) or an extreme skin reaction (fever and sore throat, burning eyes, and skin pain, as well as red or purple skin that causes blisters as well as peeling).Consult a doctor when you experience a severe drug reaction that affects various parts of your body. Symptoms may include the following: a skin rash and fever; swelling of the glands; flu-like signs; muscle pains; extreme weakness; unusual bruising; or a yellowing of your eyes or skin.

Contact your doctor immediately if you are suffering from:

  • Mood shifts, anxiety, feelings of despair, or sadness thoughts about suicide and self-harm;
  • Liver issues upper stomach, right -sided pain or dark urine jaundice (yellowing of the eyes or skin)
  • Signs of depression, mood swings and feelings of self-worth devaluation, a loss of interest in activities you once enjoyed, sleep problems that have gotten worse, and feelings of guilt about self-harm.

Warnings

Before taking Edurant, inform your doctor that you suffer from liver disease (including Hepatitis B and C), kidney disease, a past history of depression or mental illness, or if you've previously taken any HIV medication.Certain medicines may interfere with rilpivirine and must not be taken at the same time. Be sure to inform your health professionals about the medicines you are taking currently and all medicines you stop or start taking.Don't take Edurant as your sole HIV treatment. Rilpivirine should be taken together with other HIV medications that your physician has recommended.Contact your doctor immediately. If you notice mood swings or anxiety, depression is severe, and you are in despair. You may also have thoughts of taking your own life or hurting yourself.This medication won't stop you from spreading HIV to others.

Prior to use this drug

It is best not to take Edurant in case you are allergic to rilpivirine.Certain medicines may cause undesirable or harmful effects when combined with Edurant. Your doctor might alter treatments if you take:

  • Carbamazepine, oxcarbazepine, phenobarbital, phenytoin;
  • Rifampin, rifapentine;
  • Esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole
  • John's wort;
  • More than one dose of dexamethasone in addition to one dose

Inform your doctor if you have ever suffered from:

  • A serious allergic reaction to the skin following the use of a medicine that has rilpivirine in it;
  • Liver disease (rilpivirine may cause hepatitis B as well as C to return or worsen);
  • Kidney disease
  • Depression and mental illnesses

Inform your doctor if you are expecting a baby, and take the correct medications to manage your infection. HIV is able to be transmitted to your child if the virus is not managed during pregnancy. Your name might be recorded on a registry that tracks the effects of antiviral medications on your baby.Women who have HIV or AIDS are not allowed to give birth to a baby. Even if the baby is born with no HIV, it is possible that the virus will be passed on to the child through breast milk.Edurant isn't approved to be used by anyone less than 12 years of age or who weighs less than 77 lbs (35 kg).

Similar or related drugs

Biktarvy, Descovy, Truvada, Tenofovir, Atripla, Complera, and Stribild

How to take Edurant?

Use Edurant exactly as recommended by your physician. Follow all instructions on the prescription label and review all medication guides and instructions sheets. Make sure you use the medicine exactly as prescribed.Edurant is generally taken one time each day along with a healthy meal (not just a protein drink). Take the medication along with food.If taken together with each other, Edurant and Cabotegravir are typically taken one time per day for around 28 days prior to the time you change to a monthly injectionable mixture. On the day you are taking the combination of Edurant as well as cabotegravir, the next day you'll receive the first injection every month of these drugs.If you are taking Edurant and cabotegravir in order to replace an unintentional dose of the injectable combo, take Edurant and tablets of cabotegravir daily until the next injectable is scheduled.

If you're planning to not receive a monthly injection for longer than 7 days, begin taking the tablets Edurant or cabotegravir one month after the last injection. Continue taking the tablets every day until the next injection in the month is due.If required, daily Edurant or cabotegravir tablets could replace the injectable mixture for up to 2 months in succession.It is possible that you will require regular medical tests while you are taking this medication and for a few months following the last dose.Utilize all HIV medicines as directed. Review all the medication instructions you are provided. Don't alter your dosage or stop taking medication without consulting your doctor. Everyone suffering from HIV must remain under the supervision of a physician.Place the container back in the original storage container at room temperature, away from heat, moisture, and light.

Details on dosage

Usual Adult Dose for HIV Infection:

25 mg orally every day
Commentaries (for the treatment of HIV-1 in combination with cabotegravir):
The manufacturer's product information for cabotegravir-rilpivirine IM should be consulted before starting this drug to ensure therapy with cabotegravir-rilpivirine IM is appropriate.
It is recommended to take this drug along with the tablets of cabotegravir (30 mg taken orally every day) at approximately the same time every morning with a meal. The information provided by the manufacturer for tablets of cabotegravir should be read.
To assess the tolerability of this drug, oral lead-in should be used for about 1 month (at least 28 days) before the initiation of cabotegravir-rilpivirine IM.
The final oral dose should be administered on the same day injections with cabotegravir and rilpivirine are started.
If a patient plans to miss a scheduled cabotegravir-rilpivirine injection visit by more than 7 days, daily oral therapy may be used to replace up to 2 consecutive monthly injection visits; the first dose of oral therapy should be administered about 1 month after the last injection dose of cabotegravir-rilpivirine IM and continued until the day injection dosing is restarted. The manufacturer's product information for cabotegravir-rilpivirine IM should be consulted to resume monthly injection dosing.
Uses:
In conjunction with other antiretroviral drugs, to treat HIV-1 infection in patients receiving antiretroviral therapy with HIV-1 RNA in plasma as high as 100,000 copies/mL at the beginning of therapy
In combination with cabotegravir tablets for the treatment of short-term HIV-1 infection for people who are virally deficient (HIV-1 with RNA of less than 50 copies/mL) with an antiretroviral treatment regimen that is stable without any history of treatment failure and no evidence of resistance to either cabotegravir or rilpivirine. For usage as:
oral lead-in to assess the tolerability of this drug before starting rilpivirine IM (a component of cabotegravir-rilpivirine IM).
Oral therapy for patients who will miss planned injection dosing with cabotegravir-rilpivirine IM

Usual Pediatric Dose for HIV Infection:

12 years old or older, and weighing at least 35 kg, 25 mg daily, once
Use: In conjunction with other antiretroviral agents for treatment of HIV-1 infection in patients who are antiretroviral therapy-naive with HIV-1 RNA in plasma of up to 100,000 copies/mL prior to the beginning of therapy.

What happens if I miss the dose?

Consume the medication with food immediately and skip your missed dose in case you exceed 12 hours late for the dose. Don't take two doses at once.Refill your prescription prior to the expiration date of your medication.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

This medicine won't stop your illness from spreading. Be sure to not engage in unprotected sexual sex or share toothbrushes, razors, or razors. Discuss with your doctor ways to stop HIV transmission during sexual contact. Sharing needles with medicine or drugs is not a good idea.

Interaction with other drugs

Certain medications can make Edurant less effective when used in conjunction. If you are taking any of the following medications, you should take them at the same dose as the one you are taking:

  • An antacid, also known as doanosine (Videx EC), takes either of these drugs for at most 2 hours prior to or 4 hours following the time you have taken the rilpivirine.
  • Acid reducers for the stomach (such as ranitidine, cimetidine, Pepcid, Tagamet, and Zantac): Take them for at most 12 hours prior to or four hours after you have taken rilpivirine.

Edurant could cause a serious heart condition. Your risk may be greater if you utilize other medications to treat infections, asthma, heart conditions, high blood pressure, mental illness, depression, cancer, malaria, or HIV.Certain drugs can interfere with rilpivirine, and some medications should not be used simultaneously. Discuss with your doctor all the medicines you are currently taking and all medicines you begin or stop taking. This includes over-the-counter and prescription medicine, vitamins, and herbal supplements. Not all interactions are included in this list.

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Prescription only

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