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Generic name: procaine penicillin [PRO-kane-PEN-i-SIL-in]

Drug class: natural penicillins

In the U.S., Wycillin has been discontinued. There may be equivalents if generic versions have been approved and are available from the FDA.

What is Wycillin?

Wycillin is an antibacterial that fights bacteria within your body.The antibiotic Wycillin can be used to treat a variety of infections, including sexually transmitted diseases.Use only this medication as prescribed by your healthcare provider.Wycillin can be used in other ways not mentioned in this guide.

Side effects of Wycillin

If you experience any of the following symptoms of an allergic reaction, seek emergency medical attention: hives, difficulty breathing, swelling of your lips, face, tongue, or throat.

If you experience a serious adverse reaction, including:

  • Diarrhea, a condition that is watery, bloody, or both;
  • Peeling skin, severe pain, or changes in the skin color where medicine was injected.
  • Dizziness or joint or muscular pain
  • Fast or pounding heartbeats
  • You may experience numbness, tingling, or pain in your arms and legs.
  • Confusion; depression;
  • Chest pain or problems with speech, vision, or hearing;
  • Feeling like you might pass out
  • Fever, dizziness, or muscle pain.
  • Uncontrolled muscle movements; problems with walking or balance
  • Pale skin, easy bleeding or bruising, unusual weakness
  • Symptoms of flu and sore throat;
  • Urinating less or not at all
  • Rash, itching, joint discomfort, or a general feeling of unwellness;
  • Fainting is slow breathing. Slow heart rate.

Some of the less serious side effects include:

  • Pain where the injection is given
  • Vaginal itching and discharge
  • White patches on your throat or mouth;
  • Nausea, vomiting;
  • You may experience blurred vision or ringing in the ears.
  • Headache, dizziness,
  • Mild skin rash

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Similar/related drugs

Amoxicillin, Doxycycline, Ciprofloxacin, Cephalexin, Azthromycin, Metronidazole, and Clindamycin


This medication should not be used if you have an allergy to penicillin. You should tell your doctor if you've ever experienced an allergic reaction after taking a cephalosporin such as Ceftin, Cefzil, Omnicef, Keflex, and others.Tell your doctor before using Wycillin if you suffer from allergies, asthma, or have a history.

Do not inject this medication into a vein. It may cause life-threatening effects.Do not stop taking this medication until the prescribed time has passed. If your infection doesn't improve or worsens while taking Wycillin, call your doctor.Inform your doctor of all medications you take, including gout, a blood thinner or diuretic, a tetracycline antibacterial, and non-steroidal pain relievers (nsaids).

Wycillin may make birth-control pills ineffective. You can ask your doctor if you should use a non-hormonal method of contraception to prevent pregnancy when using this medication. The hormonal forms of contraception, such as birth control pills and injections, skin patches, and vaginal rings, may not be enough to prevent pregnancy while you are taking this medicine.Your doctor may order tests after you finish your Wycillin treatment to ensure that your infection is completely gone.

Before you take this drug

If you have an allergy to penicillin, this medication should not be used. You should tell your doctor if a cephalosporin antibiotic such as Ceclor or Ceftin has ever caused an allergic reaction.

You may need to adjust your dose or undergo special tests if you have one of these conditions:

  • If you have asthma, allergies, or both
  • Kidney disease is a serious condition.

FDA pregnancy class B There is no evidence that Wycillin will harm an unborn child. If you plan to get pregnant or are pregnant, tell your doctor.

Wycillin may make birth control pills ineffective. You can ask your doctor if you should use a method of birth control that is not hormonal (such as a diaphragm or spermicide). The hormonal forms of contraception, such as birth control pills and injections, skin patches, vaginal rings, and implants, may not be enough to prevent pregnancy while you are taking this medicine.

Procaine and penicillin may pass into breast milk and harm a nursing infant. If you are breastfeeding a child, do not take this medication without first consulting your doctor.

How to take Wycillin?

Wycillin can be injected into the muscle. Your doctor, nurse or another healthcare provider will administer this injection. You may be taught how to inject the medicine at home. You should not inject Wycillin yourself if you are not sure how to properly give the injection or dispose of used syringes and needles.

The injection of Wycillin should be done slowly in a muscle on the buttocks or upper thigh.Avoid injecting the medication directly into a vein. This could cause life-threatening effects.Wycillin should be administered at regular intervals.Do not stop taking the medication before it is completely cleared. You may experience improvement in your symptoms before the infection has completely disappeared. Wycillin does not treat a virus, such as a cold.

If your infection doesn't improve or worsens while you are using Wycillin, call your doctor.Each disposable needle should only be used once. Use a puncture-proof container to throw away used needles (ask the pharmacist how and where to get one). This container should be kept out of the reach of pets and children.You may experience unusual lab test results, such as tests for glucose in urine. Inform any doctor that you use Wycillin.

Your doctor may order tests after you finish your Wycillin treatment to ensure that your infection is completely gone.Keep this medication in the fridge. Do not freeze. If the medication has changed color or contains particles, do not use it.

What happens if I miss the dose?

As soon as you realise that you have missed a dose, take it as soon as possible. Wait until your next dose to take the medication, and do not use the missed dose. You should not take extra medicine to compensate for a missed dose.

What happens if I overdose?

If you suspect that you've used too much Wycillin, seek emergency medical care. Overdose symptoms include mood swings, confusion, convulsions, and agitation.

What should be avoided?

Antibiotics can cause diarrhea. This could be an indication of a new illness. Stop using the medication and contact your doctor if you experience diarrhea that is bloody or watery. If your doctor has not prescribed any medication to treat diarrhea, do not take it.

Avoid "live" vaccinations such as the typhoid, cholera, or BCG vaccine (Bacillus calmette-Guerin).

Interaction with other drug

Tell your doctor if you take any other medications, including:

  • Probenecid (Benemid);
  • A blood thinner, such as Warfarin or Coumadin;
  • Diuretics (water pills) like furosemide, hydrochlorothiazide, Hyzaar (HCTZ), Lopressor HCT (HCTZ), Vasoretic (HCTZ), Zestoretic (HCTZ), and others
  • Methotrexate (Rheumatrex, Trexall);
  • A tetracycline antibiotic, such as demeclocycline, doxycycline, minocycline, or tetracycline,
  • Nsaids are non-steroidal anti-inflammatory medications such as ibuprofen, diclofenac, etodolac, indomethacin, naproxen, meloxicam, piroxicam, and others.

There may be other drugs that interact with Wycillin. Inform your doctor of all prescription and non-prescription medications that you take. Included are minerals and herbal products, as well as drugs prescribed by doctors. Never start a new medication before consulting your doctor.