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Name of the Generic: Desvenlafaxine [des-VEN-la-FAX] des-VEN-la -FAX
Names of Brands: Khedezla, Pristiq
Forms of Dosage: Oral tablet, extended release (as base) 100 mg, 50 mg, 100 mg, 25 mg, 50 mg, 100 mg)
Drug Class: Serotonin-norepinephrine reuptake inhibitors

What is Desvenlafaxine?

Desvenlafaxine can be described as a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant.

Desvenlafaxine can be used to treat major depression disorders.Desvenlafaxine is also employed for other purposes that are not covered in this guideline.

Side effects of Desvenlafaxine

Contact a medical professional immediately. If you notice symptoms warning signs of an allergic reaction, such as itching or itching; trouble breathing; and swelling of your lips, face, and tongue,

Contact your physician immediately. If you notice any recent or sudden changes in your mood or behavior, This could include the onset of new or more severe symptoms of depression or anxiety, panic attacks, trouble sleeping, or if you are feeling angry, irritable, or impulsive, aggressive, inactive, or speaking, or if you have thoughts of taking your own life or hurting yourself.

Desvenlafaxine may cause serious side effects. Consult your physician immediately in the event that you experience:

  • A seizure;
  • Bleeding or bruising (nosebleeds or bleeding gums) and blood in your stool, urine, or stools, coughing up blood
  • Blurred vision in the eyes, pain in the eye or swelling, or seeing halos of lighting;
  • Cough or chest pain trouble breathing, coughing,
  • Low blood sodium: headache and confusion; trouble with memory or thinking; and weakness. It can also cause a feeling of unsteadiness.

Get medical attention immediately. If you experience indications that suggest serotonin syndrome, which include hallucinations, agitation, sweating, fever, chills, shivering, rapid heart rate, muscle stiffness, or twitching, You may also experience loss of coordination, nausea, vomiting, or diarrhea.

Common adverse effects of desvenlafaxine could be:

  • Dizziness, drowsiness, and anxiety;
  • More sweating;
  • Nausea, a decrease in appetite, diarrhea;
  • Sleep problems (insomnia);
  • Reduced sex drive, insanity, or difficulty getting an orgasm.

This isn't a complete list of all the side effects. Others could happen. Consult your physician for advice regarding medical adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Patients suffering from mental illness or depression may contemplate suicide. Certain young people may experience more suicidal thoughts after taking medication to treat depression. Inform your doctor immediately whenever you notice any sudden changes in your mood and behaviour or if you have thoughts about suicide.

Don't stop taking desvenlafaxine unless you first consult your physician.

Before you Take this Drug

You shouldn't make use of desvenlafaxine if you are sensitive to the desvenlafaxine ingredient or venlafaxine (Effexor).

Do not take desvenlafaxine for the next 7 days prior to or 14 days following the time you've taken any MAO inhibitor, like isocarboxazid or linezolid, blue injections, phenelzine, or tranylcypromine. A drug interaction that is dangerous can occur.

Inform your physician if you are also taking stimulant medication, opioid medication, herbal products, or medicines for mental illness, depression, Parkinson's disease, migraine headaches, severe infections, or to prevent nausea or vomiting. Desvenlafaxine interactions could result in a serious illness known as serotonin syndrome.

Talk to your physician If you've ever had:

  • Heart diseases, high blood pressure, high cholesterol, and stroke;
  • Bipolar disorder (manic depression);
  • Depression, suicidal ideas;
  • Kidney or liver disease;
  • Glaucoma;
  • Seizures or epilepsy;
  • Sexual issues;
  • Respiratory or breathing issues;
  • A bleeding or blood clotting disorder;
  • The sodium levels are low in the blood.

Patients suffering from mental illness or depression might contemplate suicide. Certain young people may experience an increased risk of suicide when they first start taking medication to treat depression. Be vigilant for any changes in your mood or signs. Your carers or family members must also be aware of abrupt changes in your behavior.

The use of this medication during pregnancy can harm your baby; however, stopping the medication may not be a good idea for you. Do not begin or stop desvenlafaxine unless you consult your physician.

If you're pregnant, then your name might be added to the pregnancy registry to monitor what effects desvenlafaxine has on the infant.

Check with your doctor to see whether it is safe to breastfeed while taking this medicine.

Not recommended for use by anyone less than 18 years old.

How to take Desvenlafaxine?

Follow all instructions on the prescription label and also read the medication guides or instruction sheets. Follow the medication precisely as directed.

Drink desvenlafaxine every day, whether or not you have food.

Suck the tablet completely and don't chew, crush, or break it.

The symptoms you experience may not improve for a few weeks.

Your blood pressure should be checked regularly.

Consult your physician if you are experiencing any changes in your sexual activity, like a loss of interest in sex or having trouble with an orgasm, as well as (in males) issues with erections or ejaculation. Certain sexual issues can be addressed.

Don't stop taking desvenlafaxine at once, or you could experience unpleasant side effects (such as confusion, agitation, and tingling, as well as the sensation of electric shock). Consult your physician before stopping the medication.

A small portion of the tablet shell might be visible in your stool, but it will not cause the medication to be less effective.

Maintain room temperature and clear of moisture and heat.

Details on Dosage

Usual Adult Dose for Depression:

50 mg taken orally every day, whether or not food
Doses ranging from 10 to 400 mg per day were evaluated in clinical studies.
There is no evidence to suggest that dosages higher than 50 mg daily offer additional benefits.
Side effects and discontinuations were more frequent at higher doses.
Efficacy for patients suffering from major depressive disorder was demonstrated through four short-term studies and two maintenance studies.
Treatment for major depression (MDD)

What Happens if I Miss a Dose?

You should take the medication as quickly as you are able, but do not take your missed dose if you are nearing the time to take the next dose. Don't take two doses at once.

What Happens If I Overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What Should be Avoided?

Avoid driving or engaging in hazardous activities until you understand how desvenlafaxine affects your body. Your reaction could be affected.

Talk to your physician prior to using a nonsteroidal anti-inflammatory medication (NSAID) like naproxen, aspirin, ibuprofen, Advil, Aleve, Motrin, and many more. Utilizing an NSAID that contains desvenlafaxine can cause bleeding or bruises easily.

Beware of drinking alcohol.

Interaction with Other Drugs

Utilizing desvenlafaxine in conjunction with other drugs that cause drowsiness can cause more of this. Consult your physician before taking opioids, sleeping pills, muscle relaxers, or medication for seizures or anxiety.

Discuss with your doctor any other medications, including blood thinners (Warfarin, Coumadin, and Jantoven) or any other medication used to stop blood clots.

Other drugs can interact with desvenlafaxine, such as prescription and over-the-counter medicines, vitamins, and herbal supplements. Inform your doctor about any other medicines you take.



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