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Generic Name: Hepatitis B immune globulin [HEP-a-TYE-tis-B-im-MYOON-GLOB-yoo-lin].
The Brand Names are: HepaGam B, Hyperhep B Nabi-HB, HepaGam B, and NovaPlus.
Drug Class: Immunoglobulins.

What is Nabi-HB?

Nabi-HB is produced from human plasma and contains proteins that help protect against the type B type of hepatitis (inflammation in the liver). Nabi-HB is a drug used to treat the spread of hepatitis B when people undergo a liver transplant or in babies born to mothers suffering from the virus. It also helps stop the spread of the development of hepatitis B in those who have come into contact with the virus via blood products that are contaminated, sexual contact with an infected individual, or who live in a house that has an infected individual. The Nabi-HB vaccine is not one. This means it won't provide long-term protection against hepatitis B. For protection over the long term, you need to take a hepatitis B vaccine, such as Engerix-B Recombivax HB or Twinrix. Nabi-HB can also be used to treat conditions not covered in this medication guide.

Side effects of Nabi-HB

Contact a medical professional immediately. If you notice any of the following symptoms as warning signs of reactions to an allergen, such as hives, difficulty breathing, or swelling of your lips, face, or tongue.

Should you experience any symptoms, seek medical assistance immediately:

  • Fever, mouth sores, gums that swell or are red.
  • Feeling lightheaded, like you're about to pass out.
  • Problems with the liver: stomach pains, nausea, weight loss, dark urine, stools that are clay-colored, jaundice (yellowing of the eyes or skin).
  • Signs of fluid buildup around your lungs, such as chest pain, discomfort in your chest when you breathe, a fast pulse, or feeling lightheaded and short of breath (especially while lying down).
  • Symptoms of a blood-clot stroke: sudden feeling of weakness or numbness (especially for one part of the body) or chest pain; difficulties breathing; fast heart rate; sweating, blood; or swelling; Your legs or arms could be suffering from pain or swelling.

Common adverse effects of Nabi-HB can include:

  • Nausea, vomiting, diarrhea, upset stomach.
  • Back pain and tiredness.
  • Tremors, memory issues, anxiety, and vision problems.
  • Symptoms of a cold like congestion, sneezing, and a sore throat.
  • Bleeding, redness, pain, or tenderness at the site in the area where the medication was injected.

This isn't a complete list of all the side effects. Other side effects could occur. Consult your physician for advice regarding medical effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


Nabi-HB can increase the risk of developing blood clots, particularly if you suffer from an illness of the heart or have a history of blood clots, if you must take a blood thinner in the case of an older person, if you're bedridden, if you are taking birth medication to control your weight and hormone substitutes, or if you utilize specific kinds of catheters. Consult your physician immediately. If you suddenly experience numbness or weakness (especially in one part of your body) and chest pain, breathing difficulties, a fast heart rate, and coughing out blood, or if there is discomfort, swelling, or redness in your legs or arms.

Before you take this drug

It is not recommended to take Nabi-HB if your body is allergic to it. Nabi-HB can increase the risk of developing blood clots, particularly if you suffer from:

  • Heart disease, coronary artery disease (hardened arterial), and blood clots in the past.
  • Risk factors for coronary artery diseases (such as smoking and being overweight, elevated blood pressure and cholesterol, and an ancestral background of coronary disease as an older person).
  • If you have to use blood thinners.
  • Using birth control pills or hormone replacement therapies (HRT) could increase your risk.
  • when you are using certain types of catheters.
  • If you suffer from bedriddenness or have other debilitating conditions.

To ensure that Nabi-HB is suitable for you, inform your physician if you suffer from:

  • An allergy against an individual's immune globulins.
  • Bleeding disorder or blood clotting like hemophilia.

Nabi-HB is created from the blood plasma of humans (part of the blood) that could contain infections and viruses. Plasma donated to the clinic is evaluated and treated to lower the chance of it being contaminated by infectious agents; however, there is a chance that it can be a carrier of the disease. Discuss with your physician the potential risks and benefits of this drug. FDA classification for pregnancy C It is not clear whether Nabi-HB could cause harm to a baby who is not yet born. Inform your doctor if you are expecting or planning to become pregnant while taking the medication. It is unclear if the hepatitis B immune globulin gets into breast milk or whether it can harm the baby who is nursing. Consult your physician if you are breastfeeding your baby.

How to take Nabi-HB?

Nabi-HB is injected directly into the muscle or vein using the infusion pump. A medical professional will administer the injection. To prevent exposure to blood that is contaminated, Nabi-HB is typically administered within the shortest time possible following exposure to an infected patient, usually in the first 7 days. The booster medicine is administered within 24 hours. Your physician may also suggest you get the hepatitis B vaccination when you begin treatment with this drug. In the case of liver transplants, Nabi-HB is injected as a part of the transplant process, followed by a few weeks or months. The drug is typically administered to patients undergoing transplants each day for 7 days. Then, it is given every two weeks over the next 11 weeks. Then, it's followed by monthly injections starting from that point on.

For protection after contact with an infected person, Nabi-HB can be administered in a single dose within 14 days of having last had contact. It is recommended that you also get the Hepatitis B vaccine in the event that you keep in contact with the person who is infected. To prevent infection in those who share the house of an affected person, Nabi-HB is recommended for children younger than 12 months of age, caregivers who are in contact with the affected person's blood, and those who share toothbrushes, razors, or other personal belongings with the person infected. Family members might also be required to be vaccinated against hepatitis B. For infants born to mothers who are infected with Hepatitis B This medication is typically given within 12 hours following the birth or if the baby is stable medically. Alongside Nabi-HB, babies should also be given the hepatitis B vaccine, which is given as three shots.

  • The initial hepatitis B vaccine is typically given at seven days old. It is administered 1 month and 6 months following the initial Hepatitis B vaccine.
  • If the infant doesn't receive the initial hepatitis B vaccination before three months of age, a subsequent dose of Nabi-HB should be administered.
  • The schedule of your child's individual booster might differ from the guidelines below. Follow the instructions of your doctor or the schedule suggested by the department of health of the state that you reside in.
  • If your baby doesn't receive the hepatitis B vaccine in any way, the second and third doses of Nabi-HB should be administered at least 3 and 6 months after having received the primary dose, respectively. Follow the directions of your physician.

When you are using Nabi-HB, it is possible that you might require periodic blood testing. This medication may produce unusual results in certain laboratory tests to measure sugar within the blood. Be sure to inform any doctor who examines you that you are taking Nabi-HB.

What happens if I miss a dose?

Contact your doctor for advice in the event that you don't make an appointment for your Nabi HB.

What happens if I overdose?

Because this medication is administered by a health specialist in a medical setting, the risk of overdose is less likely to occur.

What should be avoided?

Do not get a "live" vaccine while using Nabi-HB or for at least three months after the treatment has ended. The vaccine might not function at the same rate during this period and could not fully safeguard you against disease. Measles is a live virus that includes rubella, mumps (MMR), and rotavirus. yellow fever, typhoid varicella (chickenpox), zoster (shingles), and the nasal influenza (influenza) vaccination. It is safe to receive the hepatitis B vaccine in conjunction with Nabi-HB.

Interaction with other drugs

Other drugs can interfere with hepatitis B immune globulin, such as prescription and over-the-counter medications, vitamins, and herbal remedies. Inform your health professionals about the medicines you take currently and all medicines that you decide to stop or change your use of.