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Perseris (injection)

Generic name: risperidone (injection) [ris-PER-i-done]
Names of brands: Perseris, RisperDAL Consta, and Uzedy
Drug class: atypical antipsychotics

What is Perseris?

Perseris is prescribed to the adult population to help treat schizophrenia. Risperdal consta is prescribed to adults either by itself or in combination with lithium or valproate to aid in treating bipolar disorder. Perseris can be used for other purposes that are not mentioned in this medication guide.

Adverse effects of Perseris

Contact a medical professional immediately. Get medical attention immediately if you show symptoms or warning signs of an allergic reaction, such as hives, difficulty breathing, or swelling of your lips, face, or tongue.

Long-term or high-dose use of the drug can result in a severe movement disorder that cannot be reversed. The longer you are using Perseris, the more likely you will be diagnosed with this disorder, particularly when you're a female and/or an older adult.

Perseris can result in severe adverse effects. Contact your physician immediately in the event of:

  • Uncontrolled muscle movements in your facial muscles (chewing or smacking your lips, mouth movement, frowning, blinking, or eye movements);
  • Breast tenderness and swelling and tenderness, nipple discharge, loss of interest in sexual activity, impotence, erectile dysfunction and difficulty in having an orgasm, menstrual irregularities that are missed periods;
  • Sensation of being strangely warm or feeling cold or hot;
  • Low blood pressure; rapid or pounding heartbeats; a flutter inside your chest;
  • Breathlessness and dizziness that is sudden (like you're about to get drunk);
  • Seizure;
  • Trouble swallowing
  • Symptoms of symptoms of symptoms of infection symptoms of infection include fever, chills, a sore throat, and body aches; unusual fatigue; loss of appetite; bleeding or bruises;
  • Extreme nervous system reaction: very rigid (rigid) muscles and high fever; sweating and confusion; rapid or irregular heartbeats; tremors; or the sensation that you may be stricken with a stroke;
  • High blood sugar: increased thirst, more frequent urine output, dry mouth, and fruity breath smell;
  • Low blood cell counts—fever chills, fatigue, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin on feet and hands, and feeling lightheaded or short of breath
  • A painful or long-lasting erection that's painful or long

Common negative effects of Perseris can include:

  • Headache;
  • Fuzzy vision, blurred vision,
  • Disorientation, dizziness, fatigue;
  • Uncontrollable tremors, uncontrollable twitching muscle movements, numbness
  • Depression, agitation, anxiety, being restless, depressed mood;
  • Lower back pain, muscle or joint pain, and discomfort in your arms or legs;
  • Uneasy stomach, constipation, dry mouth, upset stomach;
  • Upper stomach pain, nausea, vomiting, diarrhea;
  • An increase in salivation;
  • Symptoms of the cold like nasal stuffiness, sneezing, sore throat,
  • Increased consumption, weight loss, or
  • Itching, swelling, bruising, as well as warmth, irritation, redness, and a firm lump (induration) at the site where the injection was administered.

This isn't an exhaustive list of all the side effects. Other side effects could be present. Contact your doctor for advice regarding medical effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar/related drugs

Caplyta, quetiapine, Abilify, Seroquel, aripiprazole, risperidone, and olanzapine


Perseris is not approved for use by older adults suffering from dementia-related psychosis.

Before taking this medication

It is not recommended to use this medication if your body is allergic to perseris and paliperidone.

Perseris can increase the risk of dying in people with dementia-related psychosis. It is not specifically approved for this purpose.

Inform your doctor if you have had or have ever experienced:

  • Heart disease or an attack;
  • Dizziness, rapid heartbeats, fainting;
  • A stroke, a TIA, or "mini-stroke";
  • Parkinson's disease, or a form of dementia known as Lewy body degeneration;
  • Trouble swallowing
  • Low white blood cell (WBC) count;
  • A severe reaction to the nervous system when using medication for treating anxiety, mood disorders, or mental illnesses like schizophrenia.
  • Diabetes (in either you or an immediate loved one of your family members);
  • High cholesterol or triglycerides
  • Muscles that are not controlled in your facial muscles (chewing or smacking your lips, frowning, tongue movements, blinking, or eye movements);
  • A seizure;
  • Low bone mineral density;
  • Breast cancer;
  • Dehydration or
  • Kidney or liver disease.

Utilizing antipsychotic medications within the last 3 months of pregnancy could create serious health issues for the infant. Tell your doctor right away if you get pregnant. Do not stop taking the medication unless you have a doctor's recommendation. If you're pregnant, then your name might be included on the registry for pregnancy to monitor how risperidone affects you as an infant.

It could be more difficult for you to become pregnant if you are taking Perseris. If you're breastfeeding, inform your doctor when you experience drowsiness, abnormal growth, tremors, or unusual muscle movements in your nursing infant.

How to take Perseris?

If you have used another antipsychotic medication, it is possible to use it for a limited period. Do not alter your dose or schedule of dosing without consulting your physician. It is possible that you will need to take Perseris via mouth (in tablet or liquid form) prior to beginning to take this medication. Follow the dosing guidelines of your doctor extremely carefully. Perseris is injected beneath either the skin or muscle. A doctor will administer this injection.

Risperdal Consta is typically given every two weeks. Perseris is typically offered once a month. Uzedy can be generally distributed once a month or twice every two months. Your blood could require frequent testing. Your doctor should examine your health frequently, and you could require additional medical tests.

Do I be concerned if I miss a dose?

Consult your physician for further instructions. If you do not make an appointment to get your Perseris,

What will happen if I take excessively?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Avoid drinking alcohol. Dangerous side effects may be experienced. Beware of becoming dehydrated or overheated when exercising, in hot weather, or simply by insufficient fluid intake. Follow your doctor's advice on the types and amounts of fluids you must consume. In certain instances, drinking too much liquid can be just as harmful as drinking too little.

Avoid driving or engaging in hazardous activities until you are aware of how Perseris affects your health. Be careful not to get up too quickly from a lying or sitting posture, as you may experience dizziness. Drowsiness or dizziness can lead to injuries, falls, or serious injuries.

Interaction with other drugs

Utilizing Perseris along with other medicines that cause you to feel drowsy could cause more of this. Talk to your doctor prior to using an opioid drug, a sleeping pill, a muscle relaxer, or medicine to treat anxiety or seizures.

It is sometimes not safe to take certain medications in conjunction with other medications. Certain medications can alter your blood levels and the other medications that you are taking, which can create side effects or render the medication less effective. Discuss with your doctor the medicines you are currently taking. A variety of drugs can cause Perseris, particularly:

  • Methylphenidate;
  • Clozapine;
  • Blood pressure medication.

This list isn't complete, and a variety of other medications could impact Perseris. This includes over-the-counter and prescription drugs, vitamins, and herbal supplements. There are many possible interactions between drugs that are included here.