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Name of the Generic: Paroxetine [pa-ROX-a-teen]
Names of Brands: Brisdelle, Paxil, Paxil CR, and Pexeva
Drug Class: Selective serotonin reuptake inhibitors

What is Paroxetine?

Paroxetine is an antidepressant that is part of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Paroxetine alters the chemical balance within the brain, which could be imbalanced in those suffering from anxiety, depression, or any other disorder.Paroxetine is a medication used in the treatment of depression and major depressive disorder.

Paroxetine can also be employed to treat anxiety disorders, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoria (PMDD).

It is believed that the Brisdelle Paroxetine brand can be utilized to manage hot flashes due to menopausal symptoms. Brisdelle is not used to treat any other condition.


It is not recommended to use paroxetine when you're also taking pimozide or thioridazine.Do not take paroxetine in the first 14 days prior to or within 14 days after you've taken any MAO inhibitor, for example, isocarboxazid or linezolid, blue injections, phenelzine, rasagiline, or selegiline. tranylcypromine.

A lot of young people are susceptible to suicide-related thoughts after the first time they take an antidepressant. Keep an eye on fluctuations in mood and symptoms. If you notice any changes or worsening symptoms, tell your physician.

Take immediate medical attention when you notice symptoms like hallucinations or agitation. stiffness or twitching, confusion, dizziness, the sensation of tingling or warmth, nausea, vomiting, sweating, diarrhea, or tremors. You may also experience racing heartbeats or a seizure (convulsions).

Stop taking paroxetine unless you first consult your physician.

Similar/related drugs

Rexulti, Trintellix, Sertraline, Trazodone, Escitalopram, Duloxetine, and Fluoxetine

Before you take this drug

This medication is recommended if you have an allergy to paroxetine or if you also take pimozide and thioridazine.

Don't use an MAO inhibitor for 14 days prior to or 14 days after taking paroxetine.An interaction that could be dangerous of a substance could take place. MAO inhibitors include isocarboxazid rasagiline, phenelzine, linezolid selegiline, tranylcypromine, and When you stop taking paroxetine, you must wait a minimum of 14 days before starting one of the MAO inhibitors.

To ensure that paroxetine is suitable for you, inform your physician if you suffer from:

  • Heart disease, excessive blood pressure, or stroke
  • Kidney or liver disease
  • A bleeding or blood clotting disorder;
  • Seizures or epilepsy;
  • Bipolar disorder (manic depression), drug addiction, or suicidal ideas;
  • Sexual problems;
  • Narrow-angle glaucoma;
  • The sodium levels are low in the blood.

Check with your physician whether you are also taking medication that is a stimulant, opioid, herbal product, or medicine for mental illness, depression, Parkinson's disease, migraine headaches, serious infections, or treatment for vomiting and nausea. These medicines can interfere with paroxetine and create an extremely serious condition known as serotonin syndrome.

A lot of young people are susceptible to suicide thoughts after beginning medication for depression. The doctor you see is likely to be able to check your health frequently. Family members or other caregivers should be on the lookout for changes in your symptoms or mood.

The use of an SSRI antidepressant while pregnant could cause lung problems that are serious or other problems for the baby. But you could experience a relapse of depression when you discontinue using your antidepressant. Contact your doctor right away if you become pregnant. Do not begin or stop using this medication without consulting your physician.

Do not use Brisdelle if you are pregnant.It is not recommended to feed your baby while taking this medication.Paroxetine is not permitted for use by anyone less than 18 years old.

How to take Paroxetine?

Use paroxetine as directed by your physician. Follow the directions on the label of your prescription and make sure you read the medication's instructions or guide sheets. The doctor might modify your dosage.Suck this tablet with extended release in its entirety, but do not crush, chew, or break it.

Make sure to shake off your oral suspension (liquid) prior to using it to determine a dose. Make use of the dosing syringe supplied or a dosage-measuring device (not an ordinary spoon).It could take up to four weeks for your symptoms to improve. Continue to take the medication according to the directions, and inform your physician if your symptoms don't improve.

Talk to your doctor if there are any changes in sexual activity, such as loss of sex-related interest, having trouble with an orgasm, or (in males) issues with erections or ejaculation. Certain sexual issues are treatable.

Do not stop taking paroxetine abruptly; you could experience painful withdrawal signs. Consult your doctor about how to safely stop taking paroxetine. Follow the instructions of your physician about the process of tapering your dose.Maintain at room temperature, far from heat, humidity, and light.

What happens If I miss a dose?

It is recommended to take the medicine promptly. However, do not take your missed dose if it's nearing the time to take the next dose. Don't take two doses at once.

What happens if I overdose?

Get medical attention immediately or contact the Poison Help line at 1-800-222-1222. A paroxetine overdose could be fatal.

What should be avoided?

Avoid driving and other hazardous activities until you understand how paroxetine can affect your body. The way you react could be impaired.

Consult your physician before taking a nonsteroidal antiinflammatory drug (NSAID) like ibuprofen, aspirin (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Utilizing an NSAID along with paroxetine can cause bruises or make you easily bleed.

Consuming alcohol while taking this medication may cause unwanted side effects.

Side effects of Paroxetine

See a doctor immediately when you notice symptoms that you are experiencing an allergic reaction due to the medication paroxetine (hives and breathing difficulties or swelling in your throat or face) or an extreme skin reaction (fever or burning eyes, sore throat or skin rashes, and an ailment that is purple or red that blisters and peels).

If you notice any new or deteriorating symptoms, contact your physician for treatment, including mood or behavior changes such as anxiety, panic attacks, or trouble sleeping. You should also tell your doctor if you feel angry, irritable, impulsive, aggressive, anxious, hyperactive (mentally and physically), more depressed, contemplating suicide, or harming yourself.

See your doctor right away if you are suffering from:

  • Racing thoughts, less desire to sleep, unusual risk-taking behaviors, feelings of extreme happiness or sadness, becoming more talkative than normal;
  • Blurred vision blurred vision, swelling or pain, or the appearance of halos around lights
  • Uncommon bone tenderness or pain, bleeding, swelling, or bruising
  • Fluctuations in weight or appetite;
  • Easily bruised uncommon bleeding (nose, mouth, vagina, or rectum) bleeding from the mouth, nose, vagina, or rectum;
  • Extreme nervous system reactions Very strenuous (rigid) muscles and sweating, high fever and confusion, rapid or uneven heartbeats, fainting,
  • Low levels of sodium in the body Low levels of sodium in the body cause headaches and disorientation; confusion; significant weakness; loss of coordination; and feeling unstable.

Get medical attention now if you are experiencing symptoms of serotonin syndrome like hallucinations, agitation, sweating, shivering, a high heart rate, stiffness of the muscles, or twitching. Also, you may experience loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of paroxetine include:

  • Vision change;
  • Weakness, drowsiness, dizziness, and tiredness;
  • Sweating, anxiety, shaking;
  • Sleep problems (insomnia);
  • Loss of appetite, nausea, diarrhea, vomiting, and constipation;
  • Dry mouth, yawning
  • Infection;
  • Headaches
  • Diminished sex drive, insanity, irregular ejaculation, or difficulty having an orgasm.

This is not a comprehensive list of possible side effects, and other side effects could occur. Contact your doctor to seek medical advice on adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Combining paroxetine with other medicines that cause you to become drowsy could increase the severity of this effect. Consult your physician before taking opioid medications, a sleeping pill, a muscle relaxer, or medicine to treat seizures or anxiety.

Discuss with your doctor all other medications, including:

  • cimetidine (Tagamet), digoxin, St. John's wort, tamoxifen, theophylline, tryptophan (sometimes called L-tryptophan), warfarin (Coumadin, Jantoven);
  • Diuretic, also known as a "water pill";
  • Heart rhythm medicine;
  • HIV and AIDS medicines;
  • Certain medicines are prescribed to treat narcolepsy or ADHD: amphetamine, atomoxetine, dextroamphetamine, Adderall, Dexedrine, Evekeo, Vyvanse, and other medications;
  • Narcotic pain medicine (fentanyl, tramadol);
  • Medication to treat mood disorders, thoughts disorders, or mental illness like lithium, buspirone, and other antidepressants or antipsychotics
  • Migraine headache medication: sumatriptan, rizatriptan, zolmitriptan, and many others;
  • Seizure medicine: phenobarbital and phenytoin.

This list isn't comprehensive. Other drugs can be incompatible with paroxetine, such as prescription and over-the-counter medicines, vitamins, and herbal products. The interactions of all potential drugs are mentioned in this medication guide.



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