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Generic Names: Albuterol and Budesonide
Dosage Form: Inhalation aerosol, for use in oral inhalation.
Classification of Drugs: Antiasthmatic combinations

The active ingredients are: micronized albuterol sulfate and micronized budesonide.
Inactive ingredients: hydrofluoroalkane (HFA 134a), porous particles 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), and calcium chloride.

What is Airsupra?

Airsupra is a prescribed combination inhaler to help with as-needed use to lower the risk of asthma exacerbations.

Airsupra blends two medications: a quick-acting beta 2-adrenergic agonist (SABA) medicine known as albuterol sulfate, as well as the oral corticosteroid (ICS) medicine known as Budesonide, in a single oral inhaler that is inhaled into the lungs by a propelled spray.

SABA medicines like albuterol can help relax the muscles that line the airways, which causes the airways to open and allow for better breathing. ICS medicines like budesonide are effective in reducing inflammation of the lung. Lung inflammation can result in breathing difficulties.

How to take Airsupra?

Airsupra can be used as a last-resort inhaler to alleviate or treat signs associated with asthma (tightening of the airways, wheezing, shortness of breath, and cough).

Airsupra can also assist in the prevention of sudden, extreme breathing problems (asthma attacks). Airsupra is administered in 2 inhalations (puffs) when needed. Don't use more than twelve inhalations (6 doses) over a 24-hour period. Airsupra is not used as a maintenance treatment for asthma. If you're taking medication long-term for the purpose of maintaining asthma symptoms under control, it is recommended that you continue taking the medication as prescribed by your physician.


It is not recommended to use Airsupra if:

  • People who are allergic to albuterol sulfate as well as budesonide or any other ingredients found in Airsupra. Check out the bottom of this page to find a complete description of all the components.

Before you take this drug

Before the treatment, inform your doctor about your medical condition such as if:

  • Have heart issues.
  • Suffer from hypertension (hypertension).
  • Are convulsions (seizures).
  • Suffer from thyroid problems.
  • Have diabetes.
  • You may have low levels of potassium in your blood.
  • Have an issue with your immune system.
  • Have you had or suffered from tuberculosis in the respiratory tract?
  • Have had any kind of parasitic, bacterial, or viral fungal infection, including herpes simplex eye infection (ocular herpes simplex), that was not treated.
  • You have been exposed to measles or chickenpox or have not been vaccinated against these diseases.
  • You are susceptible to or have an increased risk of developing weak bones. You could be at risk of weak bones if:
    • Are not active for a prolonged time
    • Are a part of the family with a history of osteoporosis.
    • Are you a woman experiencing menopausal symptoms ("the transition of the course of") or have you passed menopausal
    • Smoke cigarettes, smoke cigarettes, or
    • Are old
    • Don't eat enough (poor nutrition).
    • Use drugs that cause bones to thin (such as seizure medications and corticosteroids) for a prolonged period of time.
  • Suffer from eye issues like increased pressure in the eyes, eye glaucoma, or cataracts.
  • Suffer from liver issues.
  • Are pregnant, planning to be pregnant, or plan to be pregnant. It's not clear whether or not Airsupra could cause harm to your baby.

It is not clear whether this medication has been proven safe or effective for children.

Follow the step-by-step directions at the bottom of this page.

  • Before beginning treatment, ensure that your doctor has taught you about the use of an inhaler and that you know how to use it properly.
  • Make sure you use Airsupra precisely according to the instructions of your doctor. Don't use Airsupra more frequently than you are recommended (no greater than twelve puffs, which is equivalent to six doses) within a 24-hour period.
  • Do not modify or stop any other inhaled medication or asthma medication (oral or inhaled) without consulting your healthcare professional.
  • Contact your health care provider or seek emergency medical attention immediately if:
    • Your breathing issues get worse.
    • You should use Airsupra more often than you would normally.
    • Airsupra is not effective at alleviating your asthma.

 Pregnancy Registry: There is a registry for pregnant women who take asthma medication during pregnancy. If you become pregnant, contact the MotherToBaby Pregnancy Studies conducted by the Organization of Teratology Information Specialists at 1-877-311-8972 or visit

Before you use your Airsupra inhaler

  1. Write the use-by date.
    Write the date of use (12 months after opening the pouch) on the label of the actuator using permanent ink.
  2. Make sure you prime your Airsupra inhaler prior to the first time you use it.
    Get the cover removed from the mouthpiece by pressing the two edges of the mouthpiece and pulling it back down.
    Shake the inhaler thoroughly.
    Make sure you hold your Airsupra inhaler with your back to you and press firmly on the upper part of the indicator to release 1 puff of test in the air.
    Repeat the priming process to get a total of 4 puffs.
    You should shake the Airsupra inhaler prior to every puff.
    Extra puffs are included for priming. Don't skip priming.

What is the best time and method to prime your Airsupra inhaler?
Start your inhaler.

  • If it isn't used for longer than seven days.
  • In the event of it being dropped.
  • After washing the white actuator.

Re-priming an inhaler

Remove the cover from the mouthpiece and spray two test puffs in the air.
Make sure you shake your Airsupra inhaler prior to each puff test.
Shake before every puff test.
Additional puffs are available to help prime. Do not skimp on priming.

The proper use of your inhaler Inhaling your medication

  1. Check
    Remove the cover from the mouthpiece. Make sure the mouthpiece is free of foreign objects and take them out prior to use.
    Examine the mouthpiece.
  2. Shake and inhale.
    Shake well.
    Breathe deeply and fully.
    Place the mouthpiece in your mouth. Close your mouth around it.
    Take a deep breath and slowly as you spray 1 puff.
    Keep breathing until you are unable to breathe anymore.
    Take the mouthpiece out of your mouth. Keep your breath as long as you are able, or for as long as 10 seconds.
  3. Repeat
    Then repeat the shake and inhale for a second puff.
    Two puffs equal one dose.
  4. Cover the mouthpiece and place it back on.
    Put the mouthpiece cover back on the mouthpiece.
  5. Rinse
    Rinse your mouth with water if it is available (do not drink your water).

Every week, you should rinse your actuator. Rinse your actuator once per week.

  • Wash the actuator with water once a week so that medication does not accumulate and block the flow from the mouthpiece.
  • Do not let the canister become wet.
  • You must reconfigure the Airsupra inhaler after washing it.

Rinse the ends of both
Cleanse each side of the motor with hot water and let it sit for 30 minutes (60 seconds in total). Shake off the excess water. Don't apply soap. Don't dry with the help of a towel or a tissue.
Check your mouthpiece as well as the actuator to be sure any residue of medication is completely removed. If you notice any accumulation, repeat the weekly rinse step 2 over and over again.
Make sure you check the mouthpiece's actuator.

Allow the actuator to air dry at night, for example.

Re-assemble and re-prime
Reassemble the Airsupra after the actuator is completely dry.
Then, put the mouthpiece cover back on. Once the mouthpiece cover is put on, gently push the canister downward into the actuator. Don't insert the canister until the mouthpiece cover is removed.
Re-prime the inhaler using the steps for re-priming in the previous paragraph.

Inhaler for emergency use if it is wet
If you have to use the inhaler before it has dried,

  • Shake off as much water as you are able to.
  • Insert the canister into the actuator.
  • Shake the bottle and spray two test puffs in the air away from your face.
  • You must take the dosage prescribed.
  • Rinse the actuator once more using steps Weekly rinse steps

Storing your inhaler

  • Keep your inhaler between 68 and 77 degrees Fahrenheit (20 and 25 degrees Celsius).
  • Don't store it in a moist environment, like bathrooms.
  • Keep your inhaler and any other medications out of the reach of children.

Tossing out the contents of your Airsupra inhaler

Don't throw away your Airsupra inhaler into the garbage cans of your house.

  • When the dose indicator is at "0" or 12 months after opening the pouch in foil, when the dose indicator reaches zero "0" or 12 months after you open the foil pouch. Don't reuse or use the actuator with other medicine canisters that come from different inhalers.
    Don't puncture or toss the canister into an incinerator or fire.

The process of ordering a fresh Airsupra inhaler

  • Request a replacement. Airsupra inhaler once the arrow at the dosage indicator appears to be in the green area.

Interaction with other drugs

Inform your doctor about any medications you are taking, including prescription and non-prescription medications as well as vitamins and herbal supplements. Airsupra and other medicines can interact with each other and cause negative side effects.

In particular, you should inform your doctor that you are taking any of the following medications:

  • Medications marketed as powerful CYP3A4 inhibitors
  • Diuretics
  • Other inhaled medicines or asthma medications
  • Digoxin
  • Beta blockers
  • Monoamine oxidase inhibitors
  • Tricyclic antidepressants

Consult your doctor or pharmacist for an inventory of these medicines. If you're not certain. Be aware of the medications you are consuming. Make a list to show your healthcare professional and pharmacist every time you receive an atypical medicine.

Details on dosage

Usual Adult Dose for Asthma

Two actuations of albuterol, 90 mg, or budesonide, 80 mg, via inhalation through the mouth are required for asthma-related symptoms.

Do not consume more than six dosages (12 inhalations) within a 24-hour time frame.
Prime the inhaler prior to the first use. Prime again if the inhaler hasn't been used for longer than seven days. It can also be used after it has been lost or after cleaning.
Throw away the pills when the dose counter shows zero.

For the treatment as needed for bronchoconstriction prevention and to lower the chance of recurrences in patients suffering from asthma who are 18 years old or older.

Side Effects of  Airsupra

Airsupra can cause serious side effects, including:

  • Increasing trouble breathing, wheezing, coughing, and wheezing (paradoxical asthma). If this occurs, stop using Airsupra and contact your physician or seek urgent medical attention immediately. The most likely cause of paradoxical bronchospasm is the first exposure to a new container of medicine.
  • Heart conditions, including increased heart rate and blood pressure.
  • Potential death for those who consume excessive Airsupra.
  • Extremely allergic reactions. Inform your doctor or seek medical emergency treatment immediately if you suffer from:
    • The skin, redness, or swelling
    • Extreme itching
    • Swelling of the mouth, tongue, and face
    • Difficulty breathing or swallowing
    • Chest pain
  • Changes in blood laboratory concentrations Low levels of potassium (hypokalemia) could cause abnormal heart rhythms. Your healthcare provider can conduct blood tests to test the levels of potassium in your blood during treatment.
  • The immune system is weaker, and there are greater chances of contracting an infection. Inform your doctor about any indications and symptoms of infection. This includes:
    • Febrile
    • Pain
    • Aches
    • Chills
    • Feeling tired
    • Nausea and vomiting
  • Fungal infection that occurs in your throat and mouth (thrush). This is a very common result. Cleanse the mouth using water in the event that it is available, but do not swallow after taking Airsupra to reduce the chances of developing thrush.
  • Diminished functioning of the adrenal gland (adrenal dysfunction). Adrenal insufficiency refers to a condition where the adrenal glands fail to produce enough steroid hormones. It can occur when you begin using a medication that contains an ICS (such as Airsupra). If your body is under stress due to trauma, fever (such as a car crash), infection, or even surgery, adrenal insufficiency could worsen. The signs of adrenal insufficiency are:
    • Feeling tired
    • Inability to focus
    • Weaknesses
    • Nausea and vomiting
    • Low blood pressure
  • Bone loss or weakness (osteoporosis). Your doctor should test you for this condition during your treatment.
  • Eye problems, which include cataracts and glaucoma. You should have regular eye examinations throughout treatment.

Consult your physician or seek medical attention immediately if you exhibit signs of one of the severe side effects mentioned above.

Common adverse Effects:

  • Headache
  • Cough
  • Hoarseness

Talk to your healthcare provider about any side effects that bother you or do not disappear. There are many negative side effects. For more information, talk to your physician or pharmacist.

Contact your doctor to seek medical advice on possible side effects. You can report any side effects to the FDA at 1-800-FDA-1088. You can also report any adverse reactions to AstraZeneca at 1-800-236.9933.

What should be avoided?

Some medicines are used for reasons other than those listed in the patient information leaflet. Use this medicine only to treat a condition for which it is not recommended. Don't give it to others, regardless of whether they have the same problem as you. It may cause harm to them. Ask your doctor or pharmacist for a list of resources specifically written for healthcare professionals.

How do I store Airsupra?

  • Keep the Airsupra inhaler between 68oF and 77oF (20oC to 25oC) in a room with a temperature range of 68oF to 77oF (20oC to 25oC). Store it in a dry location away from sunlight and heat.
  • Keep the inhaler in a foil pouch that is sealed, and only untie it when it is ready to use.
  • Don't put an opening in the inhaler's canister.
  • Don't store or use Airsupra near heat or flames. Temperatures that exceed 120 oF (49 oC) could cause the canister to explode.
  • Don't throw the canister into a flame or incinerator.
  • Toss away Airsupra twelve months after opening the foil pouch or when the dose indicator is at 0," whichever comes first.

Make sure that all medications are out of reach of pets and children.



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