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Generic Name: Sildenafil
Form of dosage: oral suspension (10 mg/mL).
Agents to treat pulmonary hypertension

What is Liqrev?

For pulmonary artery hypertension, Liqrev suspension (sildenafil) is used to improve the ability of adult patients to exercise as well as to delay any clinical worsening. Liqrev lowers the blood pressure and increases cardiac output by relaxing the blood vessel muscles.Liqrev, a phosphodiesterase-5 inhibitor (PDE-5), works by blocking PDE-5. Liqrev comes as an oral suspension, which is taken three times per day.Liqrev received FDA approval on April 28, 2023.Liqrev should not be taken if you regularly or occasionally take nitrate medicine. This can increase the risk of a serious and sudden drop in blood pressure. Some examples of nitrate medicines are nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and "poppers".Some medicines may cause harmful or unwanted effects when combined with sildenafil. Inform your doctor of all the medications you are taking, including Riociguat and Adempas.If you experience a sudden loss of vision, stop using Liqrev immediately and seek emergency medical attention.

Similar/related drugs

Sildenafil, Tadalafil, Adcirca, Revatio, Ambrisentan, and Opsumit

Before you take this drug

Liqrev should not be used if you have an allergy to sildenafil or:

  • If you are taking other medications to treat pulmonary arterial high blood pressure, such as Adepas (riociguat),

Sildenafil should not be taken if you also take a nitrate medication for chest pains or heart problems. It includes nitroglycerin and isosorbide monnitrate. Some recreational drugs, such as amyl or nitrite (poppers), also contain nitrates. Sildenafil combined with nitrate medicines can cause a rapid and severe drop in blood pressure.

Tell your doctor about any of the following to ensure Liqrev will be safe for you:

  • Heart problems (chest discomfort, a heart rhythm disorder, or a heart attack).
  • High or low blood pressure
  • Blood circulation problems
  • Retinitis Pigmentosa
  • Blindness in both or one eye
  • Bleeding problems
  • A stomach ulcer
  • PVOD (pulmonary venoocclusive disease)
  • Have you ever experienced hearing problems like ringing in your ears, dizziness, or loss of hearing?
  • Liver or kidney disease
  • A blood cell disorder, such as sickle cell anaemia or myeloma multiple
  • A physical deformity (such as Peyronie’s disease).

Sildenafil may cause sudden vision loss by decreasing blood flow to the eye's optic nerve. Sildenafil has caused sudden vision loss in a few people. Most of these patients had other health problems, such as heart disease, diabetes, high blood pressure, high cholesterol, or pre-existing eye conditions. This medicine may be the cause of some vision problems.

Tell your doctor if you:

  • See "Who should not use Liqrev?" Liqrev is not suitable for everyone.
  • High blood pressure medications
  • Medicines for erectile dysfunction (impotence). Liqrev is a medicine that contains sildenafil. This is the same medication found in Viagra (r), which is used to treat erectile dysfunction. Liqrev should not be taken with Viagra or any other PDE-5-inhibitors, such as avanafil (Stendra), Cialis (tadalafil), or Levitra (vardenafil).

Sildenafil may be safe and effective for children under 1 year old.


Inform your doctor that you are expecting. Sildenafil is not known to harm a baby. PAH during pregnancy can cause serious complications, such as stroke or heart failure. Liqrev can be used to treat PAH. This may have a greater benefit than any risk for the baby.


Breastfeeding may not be possible while taking this medication. You should ask your doctor if there are any risks.

How to take Liqrev?

Read all instructions and directions that come with your medication.. Read all the instructions and directions included on the prescription label.Shake the bottle at least 10 seconds prior to measuring your dose.Use an oral dose syringe to measure your prescribed dosage. Your healthcare provider may change your dose. You should not stop taking the medicine or change the dose without first consulting your healthcare provider.Take the prescribed dose orally. Liqrev should be taken three times per day.

Details on dosage

Adult Liqrev Dosage for Pulmonary Hypertension

  • Orally, take 20 mg three times per day.

Use: treating PAH in adults (WHO Group I) to improve their exercise capacity and delay clinical deterioration.Liqrev oral suspension is available at 10 mg/mL.

What happens if I miss the dose?

You should take your missed dose as soon as possible, but skip it if you are about to take your next dose. Never take two doses in one go.

What happens if I overdose?

For poison assistance, call 1-800-222-1222 or get immediate medical help.

What should be avoided?

Alcohol consumption can have side effects when taken with this medication.Grapefruit can interact with this medication and cause unwanted side effects. Grapefruit products should be avoided.Do not use any other medications to treat impotence, such as alprostadil and yohimbine, without first consulting your doctor.

Side effects of Liqrev

If you experience any of the following symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, or tongue, or swelling in your throat, face, or mouth, seek emergency medical attention.

If you experience:

  • Heart attack symptoms include chest pain, nausea, and sweating.
  • Vision changes or sudden vision loss; or
  • If the erection lasts more than four hours or is painful, it can cause damage to the penis.

If you experience:

  • Coughing up foamy mucus with severe shortness of breath;
  • Hearing loss or ringing in the ears
  • Irregular heartbeat
  • You may experience swelling of your ankles, feet, or hands.
  • A seizure; or (convulsions); or
  • Feeling lightheaded, like you might pass out.

Liqrev may cause side effects such as:

  • Flushing (warmth, redness, or tingly sensation);
  • Headache, dizziness;
  • Anomalies of vision (blurred or altered colour vision, blurred vision)
  • Nosebleeds, a runny or stuffy nasal condition
  • Sleep problems (insomnia);
  • Muscle pain, back pain, or an upset stomach.

There may be other side effects. For medical advice on side effects, call your doctor. To report adverse effects, you can contact the FDA at 1-800-FDA-1088.

Interaction with other drug

Liqrev should not be taken with other similar medications, such as Cialis (tadalafil), Levitra (vardenafil), or avanafil Tell your doctor about all medications that you take.

Tell your doctor about your other medications, including:

  • Drugs to treat high blood pressure or prostate disorders;
  • Antifungal medicine: ketoconazole or itraconazole; or
  • Medicine to treat HIV/AIDS: ritonavir, among others.

This list is incomplete. Other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products, may interact with sildenafil. The list is not exhaustive.




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