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The generic name is pseudoephedrine.

Brand names include Contac Cold, Nexafed, Silfedrine, Sudafed Children’s Nasal Decongestant sudogest, Suphedrin, and Drixoral Decongestant Non-Drowsy.
Drug class: Decongestants

What is Silfedrine?

Silfedrine is a treatment for sinus and nasal congestion or obstruction of the tubes that draw fluid out of your ears, also known as the eustachian tube.Silfedrine can also be used for reasons not mentioned in this guideline.

Side effects of Silfedrine

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, like hives, trouble breathing, or swelling of your lips, face, or tongue.

Silfedrine may cause serious side effects. Take a break from Silfedrine and consult your physician immediately if you suffer from:

  • Dizziness;
  • Anxiety
  • Sleep problems (insomnia).

More minor side effects might be more likely, and you could not experience any whatsoever.

This is not a comprehensive list of possible side effects, and other side effects could occur. Contact your doctor to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Follow all the instructions on the label and in the package. Make sure you use the product exactly as it is indicated.

Prior to use this drug

You shouldn't make use of Silfedrine in case you have an allergy to it.Do not take Silfedrine if you have taken an MAO inhibitor within the last 14 days. A potentially dangerous interaction between drugs could occur. MAO inhibitors are isocarboxazid linezolid, Methylene blue injection, rasagiline, phenelzine, tranylcypromine, and many others.

Ask your doctor or pharmacist to determine if this medication is suitable for you if you have ever used:

  • The heart condition (also known as excessive blood pressure );
  • Prostate enlargement and urination issues
  • Diabetes
  • Thyroid disorders are a common problem.

Similar or related drugs

Epinephrine topical, pseudoephedrine, phenylephrine nasal, sodium chloride nasal, and AFRI

How to take Silfedrine?

Follow exactly the instructions on the label or as directed by your physician.

Don't give this medication to children who are less than 4 years old. Always consult a physician prior to giving a cold or cough medicine to an infant. Death can occur due to the misuse of cough or cold medications for very young children.Begin with a glass of water.Don't crush, chew, or break the extended-release tablets. Take it in whole.

It is possible to shake up the suspension (liquid) thoroughly prior to measuring the dose. Take measurements of liquid medication using the syringe that is provided for dosing, a dosing spoon, or a medicine cup. If you don't have a device for measuring doses, request one from your pharmacist.Contact your physician if your symptoms don't improve after seven days of treatment or if you are suffering from a high fever.Place it in a cool, dry place far from heat and moisture.

What happens if I miss the dose?

Because silfedrine is only used in times of need, it is possible that you are not on a schedule of doses. If you're following a regimen, take the missed dose as quickly as you can remember. Do not take any missed doses if it's close to the time of the next dose scheduled. Take care not to use additional medication in an attempt to compensate for missed dosage.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Do not take these medications if you use weight loss pills, caffeine pills, or any other stimulant (such as ADHD medication). Combining a stimulant with a decongestant could increase the chance of having unpleasant side effects.

Consult a physician or pharmacist before taking any other cold or cough medication. A lot of combination medicines include silfedrine or a similar decongestant. Combining certain medicines could cause you to take excessive amounts of this kind of medication.

Interaction with other drugs

Other medications may interact with Silfedrine, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician of any other medications you are taking.