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Generic names: aliskiren, amlodipine, and hydrochlorothiazide [AL-is-KYE-ren, am-LOE-de-peen, HYE-droe-klor-oh-THYE-a-zide]
Drug class: Miscellaneous antihypertensive combinations

What is Amturnide?

Amturnide is a mixture of aliskiren, amlodipine, and hydrochlorothiazide. Aliskiren is an antihypertensive (blood pressure reduction) medication. It works by reducing the presence of certain substances within the body that can narrow blood vessels and increase blood pressure.Amlodipine is part of a family of drugs known as calcium channel blockers. Amlodipine reduces (widens) blood vessels and increases blood flow.Hydrochlorothiazide is a diuretic thiazide (water pill) that helps prevent your body from taking in excessive salt, which may result in fluid retention.Amturnide is a medication used for treating hypertension.Amturnide is usually prescribed in conjunction with other blood pressure medications, which have been tried but with no success in treating the symptoms.


It is not recommended to take Amturnide if you're unable to urinate or if you are sensitive to sulfa-based drugs.Do not take Amturnide when you are expecting. If you are pregnant, discontinue taking Amturnide and consult your physician immediately.If you are diabetic, it is advised not to use this medication in conjunction with other blood pressure or heart-related medications (such as Accupril, Benicar, Capoten, Cozaar, Diovan, Lotensin, Mavik, Prinivil, Vasotec, and many others).Before taking Amturnide, inform your physician if you suffer from liver or kidney disease, lupus, glaucoma, asthma, congestive heart failure, angina (chest pain), coronary artery disease, an electrolyte deficiency (such as low magnesium or potassium), or a penicillin allergy, particularly if you're following a low-salt diet or if you've experienced an allergic reaction to blood pressure medications.The pain in your chest may get more severe when you begin taking amturnide or if your dosage is increased. Consult your doctor if you feel the chest pain you experience is intense or persists.

Before you take this drug

It is not recommended to take amturnide if you are intolerant of aliskiren, amlodipine, or hydrochlorothiazide. if you suffer from:

  • It is impossible to urinate
  • You are sensitive to sulfa-based drugs.

If you are diabetic, do not take Amturnide along with other blood pressure medications like:

  • Azilsartan (Edarbi, Edarbyclor), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), olmesartan (Azar, Benicar), valsartan (Diovan, Exforge, Tribenzor), telmisartan (Micardis);
  • Benazepril (Lotensin), Captopril (Capotene, and Capozide) Enalapril, benazepril (Vasotec, Vasoretic), fosinopril (Monopril), Lisinopril, fosinopril (Prinivil, Zestoretic, Zestril), moexipril (Uniretic, Univasc), perindopril (Aceon), quinapril (Accupril, Accuretic), Ramipril (Altace), or the drug trandolapril (Mavik, Tarka)

It is also possible to steer clear of these medicines that contain amturnide when you suffer from kidney problems.

To ensure that amturnide is appropriate for you, consult your physician if you suffer from:

  • Kidney disease;
  • Liver disease;
  • Heart disease or an earlier heart attack
  • Coronary artery disease (hardened coronary arteries);
  • Glaucoma;
  • Asthma or allergies
  • Gout;
  • Diabetes;
  • Systemic lupus erythematosus (SLE);
  • The imbalance of electrolytes (such as a low level of magnesium, potassium, or magnesium in the blood);
  • If you're following an e-diet that is low in salt,
  • An allergy to penicillin.

Do not take Amturnide while you are expecting. If you find yourself pregnant, then stop taking this medication and notify your doctor promptly. Aliskiren can cause injury or even death to the baby's unborn if you take the medication during your third or second trimester.It is unclear if the medicine is absorbed into breast milk or if there is a risk to the nursing infant. It is not recommended to breastfeed when taking Amturnide.This medication is not approved to be used by anyone less than 18 years old.

How to take Amturnide?

You should take Amturnide exactly as directed by your physician. Use Amturnide exactly as directed by your physician. Be sure to follow all instructions listed on your prescription label. Your doctor may modify your dose. Don't take this medication in greater or lesser amounts or for longer periods than prescribed.There is a possibility of having very low blood pressure while taking this medication. Consult your physician if you are experiencing vomiting and diarrhoea or are feeling extremely dizzy.Your blood pressure is likely to be checked regularly.If you are in need of medical or surgical procedures, be sure to inform your surgeon in advance that you're taking Amturnide. You might have to stop taking the medication for a short period of time.Continue to take Amturnide as directed, regardless of whether you feel good. A high blood pressure can have no signs. It is possible that you will need blood pressure medication throughout your life.Place the container back in the original at ambient temperature, away from heat and moisture.

Details on dosage

Usual Adult Dose for Hypertension:

The first dose is 1 tablet daily, orally.
The dose can be increased after two weeks of treatment.
Maximum dose: aliskiren, amlodipine, or hydrochlorothiazide 300/10/25 mg orally daily.
The combination product can be used in place of amlodipine, aliskiren, and hydrochlorothiazide in separate tablets.
Tablets should be taken identically each day, whether without or with a meal. (High-fat meals reduce the absorption of aliskiren significantly.)

What happens if I miss the dose?

Do the dose you missed as soon as you can remember. Do not take any missed doses if it's nearing the time for the next dose. Do not take any additional medicine to make up for the missed dose.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

If you are also taking colestipol or cholestyramine, you should not take these medications within 4 hours prior to or after taking amturnide.Don't take salt substitutes or potassium supplements when you take this medication unless your doctor has instructed you to.Beware of taking food items that are rich in fat, as this could make it difficult for the body to absorb the aliskiren.Do not drink alcohol. It could increase your blood pressure and make it more difficult to take care of some adverse effects of this medication.Be careful not to get up too fast from a lying or seated posture, as you might get dizzy. Start slowly and steady yourself to avoid falling.

Side effects of Amturnide

Take immediate medical attention. If you are experiencing symptoms of an allergic reaction to Amturnide: hives; vomiting; severe stomach pain; breathing problems; dizziness; and swelling of your lips, face, and throat.Your chest pain might worsen when you first take the medicine or when the dosage is increased. Inform your doctor if you experience chest pain that is extreme or continues to bother you.

Contact your doctor immediately. If you suffer from:

  • An uncomfortable sensation of lightheadedness;
  • Very little or no urine;
  • Eye pain, vision issues;
  • Lower levels of sodium in the body (headache, disorientation, speech slurred, severe weakness, vomiting, loss of balance, sensation unstable);
  • Very high in potassium, nausea, an irregular or slow pulse rate, weakening, or loss of motion;
  • Low potassium leg cramps, diarrhoea, irregular heartbeats, more frequent urination or thirst sensations of numbness or tingling muscles becoming weak or limp;
  • Symptoms resembling lupus joint pains with the appearance of skin sores and fever. Butterflies-shaped skin rash on your nose and cheeks or numbness of your toes and fingers;
  • Liver issues nausea, stomach discomfort, itching, fatigue feeling nausea, weight loss, dark urine, stools that are clay-coloured or jaundice (yellowing of the eyes or skin) or
  • Serious skin reactions such as the throat being sore, there's swelling on your tongue or face, burning eyes, or pain in your skin that is followed by the appearance of a purple or red skin eruption that can spread (especially on the face or the upper body) and lead to blistering and peeling.

Common side effects of amturnide include:

  • Swelling in your ankles, hands, or feet;
  • Dizziness, headache, tired feeling
  • Cough;
  • Diarrhoea;
  • Cold symptoms like nasal stuffiness, sneezing, and a sore throat.

This isn't an exhaustive list of all the side effects. Others could happen. Consult your physician for advice regarding medical effects. Report your adverse reactions directly to the Food and Drug Administration by dialing 1-800-FDA-1088.

Interaction with other drugs

Inform your doctor about all the medicines you are currently taking and all you are about to start or stop taking, in particular:

  • Cyclosporine;
  • Lithium;
  • Any blood pressure or heart medication;
  • Diuretic or "water pill";
  • Oral diabetes medication or insulin;
  • A potassium supplement like k-dur or k-con;
  • Salt substitutes containing potassium
  • Antifungal medicine: itraconazole, ketoconazole;
  • Cholesterol medication: atorvastatin, cholestyramine, colestipol, simvastatin, lipitor, zocor;
  • Hiv and aids medication such as indinavir, ritonavir, and others;
  • Nsds (nonsteroidal anti-inflammatory medications): aspirin, ibuprofen (advil, motrin), naproxen (aleve), celecoxib, diclofenac, indomethacin, meloxicam, and more.

This list isn't complete. Other medications can be incompatible with aliskiren, amlodipine, aliskiren, and hydrochlorothiazide. These include medicines that are available on prescription or over-the-counter, as well as vitamins and herbal products. Not all interactions are included in this guideline for medications.




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