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Generic name: sitagliptin [SI-ta-glip-tin]
Brand Name: Januaryuvia
Form of dosage: oral tablet (100 mg, 25 mg, 50 mg).
Drug class: dipeptidyl peptidase 4 inhibitors

What is Sitagliptin?

Sitagliptin can be used in conjunction with diet and physical activity to help control blood sugar levels among adults who have type 2 diabetes mellitus. Sitagliptin does not treat type 1 diabetes. Sitagliptin can be used in other ways not mentioned in this guide.

Side effects of Sitagliptin

If you experience symptoms of an allergic response (hives or difficulty breathing, swelling on your face or in your throat), or a severe reaction to the skin (fever or sore neck, or burning in your eye, or skin pain or blistering, or a red or purple rash that is spreading and blistering, or skin that has a rash or skin rash), seek emergency medical attention.

If you experience symptoms, stop taking sitagliptin immediately and contact your doctor. Severe abdominal pain that spreads to the back with or without nausea.

Sitagliptin may cause serious side effects. If you experience:

  • Severe autoimmune reaction: itching, blisters, breakdown in the outer layer of skin;
  • You may experience severe pain or persistent joint pain.
  • There is little or no urine production.
  • Symptoms of heart failure include shortness of breath (even when lying down) and swelling in the legs or feet. Rapid weight gain.

Side effects of sitagliptin include:

  • Low blood sugar
  • Headache
  • Sore throat, runny nose, or congestion

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


If you experience symptoms such as shortness of breath, swelling of your feet or legs (even when lying down), or rapid weight gain, call your doctor. If you experience pancreatitis symptoms, stop taking sitagliptin immediately and contact your doctor.

Before you take this drug

Sitagliptin should not be used if the patient is allergic to the drug or has diabetic ketoacidosis. (Call your doctor for insulin treatment.)

Inform your doctor of any of the following issues:

  • Kidney disease (or dialysis if you have it);
  • Heart problems
  • Pancreatitis;
  • High triglycerides
  • Gallstones
  • Alcoholism.

If you're pregnant or plan to become pregnant, follow your doctor's advice about sitagliptin. You may be required to register your name on a sitagliptin registry when you first start taking this medication.

You may not be able to breastfeed your baby if you are taking this medication. You should ask your doctor if there are any risks. Sitagliptin should not be used by anyone under the age of 18.

How to take Sitagliptin?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed. Take this medication with or without food. You should follow your doctor's directions. You may also need blood tests in your doctor's clinic.

If you have low blood glucose (hypoglycemia), then you may feel hungry, dizzy, or confused. You might also be anxious or shaken. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (fruit juices, hard candies, crackers, or raisins). If your hypoglycemia becomes severe, your physician may recommend a glucagon injectable kit as treatment. Make sure that your family and friends are familiar with how to administer this injection if you need it in an emergency. Watch for signs of hyperglycemia (hyperglycemia), such as increased thirst and urination.

Stress, illness, surgery, and alcohol consumption can affect blood sugar levels. Before making any adjustments or alterations to your medication or dosage schedule, always seek advice from your physician first. Sitagliptin may be part of a comprehensive treatment plan that includes diet, exercise, and weight management, as well as blood sugar testing and other medical attention. You should follow your doctor's advice. Store away from moisture, heat, and light at room temperature.

Details on dosage

Adult dosage for diabetes type 2:

Take 100 mg once daily.
When used with an insulin-secretagogue (e.g., sulfonylurea or insulin), they can be used in combination to reduce hypoglycemia.
Use: To improve the glycemic level in patients with type II diabetes mellitus.

What happens if I miss the dose?

If it is almost time for your next dose, skip any missed one altogether and never double up on medication at once.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Low blood sugar can cause extreme weakness, blurred or distorted vision, sweating, and difficulty speaking. Other symptoms include tremors, stomach discomfort, confusion, seizures (convulsions), confusion, and confusion.

What should be avoided?

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Interaction with other drug

Sitagliptin can be affected by other medications. Other drugs can also have an impact on blood sugar levels. If you use insulin, your chances of having low blood sugar may increase.

Sitagliptin can be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop using.



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