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Name of the generic: amoxapine [a-MOX-apeen]
Name of the brand: Asendin
Dosage format: oral tablet (100 mg, 150 mg, 25 mg, 50 mg)
The class of drugs: tricyclic antidepressants

What is Amoxapine?

Amoxapine is a tricyclic antidepressant utilised to treat symptoms that are a result of depression, anxiety, or stress.Amoxapine is also employed for other purposes that are not covered in this medication guide.

Side effects of Amoxapine

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as hives, difficulty breathing, or swelling of your lips, face, and tongue.If you notice any new or more severe symptoms, report them to your physician, including changes in your mood or behaviour, anxieties, panic attacks, or trouble sleeping. You should also tell your doctor about the feeling of being angry, irritable, impulsive, or aggressive. active, restless (mental as well as physically), or more depressed, or are contemplating suicide or harming yourself.

Amoxapine can cause serious adverse side effects. Consult your physician immediately in the event:

  • Skin rash, fever;
  • Muscles that are not controlled in your facial muscles (chewing lipsmacking, chewing mouth movements, frowning, blinking, or eye movements);
  • Beats of your heart or the sound of fluttering your chest
  • Chest discomfort or pressure that is spreading to your shoulder or jaw;
  • Suddenly numbness or weakness (especially in one part of your body) or slurred speech difficulties with balance or vision
  • Nervous system reactions that are severe, very rigid (rigid) muscles, and high fever sweating as well as confusion, quick or irregular heartbeats, tremors, and a feeling that you could faint.

Common adverse reactions to amoxapine include:

  • Drowsiness;
  • Constipation;
  • Dry mouth
  • Blurred vision.

This is not an exhaustive listing of all the side effects. Others could happen. Consult your doctor for medical advice regarding the consequences. It is possible to report any adverse reactions to the FDA by calling 1-800-FDA-1088.


Amoxapine should not be used in the event that you have recently suffered a cardiac attack.Do not take amoxapine if you've taken an MAO inhibitor within the last 14 days, for example, linezolid and isocarboxazid, as well as methylene blue injections, phenelzine, rasagiline, selegiline, or tranylcypromine.A few young people may have thoughts about suicide after using an antidepressant. Keep vigilant for changes in your mood or symptoms. Inform your doctor if you notice any changes or worsening symptoms.

Prior to use this drug

It is not recommended to use amoxapine when you are allergic to it, or:

  • If you've recently suffered from an attack of the heart,

Do not take trimipramine when you've taken an MAO inhibitor in the last 14 days. A risky drug interaction may occur. MAO inhibitors include isocarboxazid linezolid, Methylene blue injection rasagiline, phenelzine, tranylcypromine, and others.Discuss with your physician if you have taken any "SSRI" antidepressant in the last 5 weeks, for example, fluoxetine, escitalopram, or citalopram. (Prozac), fluvoxamine, sertraline, paroxetine (Zoloft), trazodone, or vilazodone.

Contact your physician if had any of the following:

  • Heart disease, stroke, or seizures;
  • Kidney disease;
  • Schizophrenia or any other mental illness
  • Diabetes (amoxapine could increase or decrease blood sugar levels);
  • Bipolar disorder (manic depression);
  • If you're being treated with electroshocks,
  • Glaucoma;
  • Urination problems.

Some young people might contemplate suicide as they the first time they take an antidepressant. Your doctor should be able to check your progress regularly. Your family members and other carers should be on the lookout for changes in your symptoms or mood.See your doctor if you are breastfeeding or expecting.Amoxapine is not a drug that has been approved for use by any person younger than 18 years of age.

How to take Amoxapine?

Follow the instructions on the prescription label and go through all medication guides or instructions sheets. The doctor might alter the dosage. Make sure you take the medication precisely as directed.If you take amoxapine at least once each day, take the dose before bedtime.It could take as long as three weeks before symptoms begin to improve. Use the medication exactly according to instructions, and notify your physician if your symptoms don't improve.Don't stop using amoxapine in a hurry, or you may experience uncomfortable withdrawal effects. Consult your physician about how to completely stop taking trimipramine.Keep at room temperature and free of heat and moisture. Close the bottle when not being used.

Details on dosage

Usual Adult Dose for Depression:

Initial dosage: 50 mg orally, 2-3 times per day.
Dosage for maintenance 100 mg taken orally 3 to 4 times per day
Maximum dose: 600 mg/day
Increases of more than 300 mg/day should be taken only in the event that 300 mg/day has not been effective for at least two weeks.
Patients admitted to hospitals who are resistant to treatment with antidepressants and do not have a known history of seizures due to convulsions might be able to have their dosage increased up to 600 mg/day in divided doses.
The drug is available in a single dosage, but not exceeding 300 mg, and is preferably taken in the evening before bedtime.
Doses greater than 300 mg must be administered in doses.
Relief of symptoms of depression in patients suffering from depressive disorders that are reactive or neurotic, as well as those suffering from endogenous and depressive psychosis
Depression accompanied by agitation or anxiety

Usual Geriatric Dose for Depression:

Initial dose: 25 mg taken orally 2-3 times per day.
Dosage for maintenance 50 mg taken orally 2 to 3 times per day
Maximum dose: 300 mg/day
When a dose that is effective is established, the drug can be administered in one dosage at bedtime, but it should not exceed 300 mg.
The recommended maintenance dosage is the dose that can maintain the remission.
If symptoms return, If symptoms reappear, the dosage should be increased back to previously prescribed levels until symptoms are controlled.
Relief of depression-related symptoms in patients suffering from symptoms of reactive or neurotic depressive disorders as well as endogenous or psychotic depression
Depression accompanied by agitation or anxiety

What happens if I miss the dose?

The medication should be taken promptly. However, do not take your missed dose if it's nearing the time to take the next dose. Don't have two doses at one time.

What happens if I overdose?

For medical emergencies, seek emergency treatment or contact the Poison Help Line at 1-800-222-1222. An amoxapine overdose could be fatal.Overdose symptoms may include seizures (convulsions), acidosis, or coma.

What should be avoided?

Alcohol consumption with amoxapine may cause adverse reactions.Avoid driving and other hazardous activities until you are aware of the effects of this medication on your body. The way you react could be impaired.

Interaction with other drugs

Amoxapine, in combination with other drugs that cause you to become drowsy, could increase the severity of this effect. Talk to your doctor prior to using opioids, a sleeping pill such as a muscle relaxer, or medication to treat seizures or anxiety.Amoxapine can be affected by a variety of drugs. It includes over-the-counter and prescription supplements, vitamins, medications as well as herbal supplements. Not all interactions are included in this list. Inform your doctor of your current medications and any medication you begin or stop taking.




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