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Generic Name: Paromomycin
Names of Brands: Humatin, Paromycin
Dosage Form: Oral capsule (250 mg)
Drug Classes: Amebicides, aminoglycosides

What is Paromomycin?

Paromomycin is an antibiotic that can be used to treat specific intestinal diseases. Paromomycin is also used to treat liver issues, in particular.

Paromomycin can also be employed for other purposes that are not covered in this guideline.

Side effects of Paromomycin

See a doctor immediately. If you are experiencing symptoms that are warning signs of an allergic response, like hives, trouble breathing, and swelling of your lips, face, and throat,

Paromomycin could cause severe adverse reactions. Consult your physician immediately. If you suffer from:

  • Diarrhea that is either watery or bloody.
  • More severe symptoms.

Common side effects of paromomycin can include:

  • Nausea, stomach cramps,
  • Mild diarrhea.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Follow the instructions on the label of your medication and the package. Inform your healthcare professionals about your medical ailments and allergies, as well as the medicines you are taking.

Before you take this drug

It is not recommended to use paromomycin when you are allergic to it or suffer from intestinal obstruction.

Inform your doctor if you have ever suffered from:

  • Kidney disease;
  • An intestinal disorder, such as ulcerative colitis;
  • Any allergies.

Inform your doctor if you are nursing or pregnant.

How to take Paromomycin?

Follow the instructions on the prescription label and go through all medication guides or instructions. Make sure you use the medication exactly as prescribed.Always take paromomycin in conjunction with food to treat the intractable intestinal disease.

Make sure to take this medicine for the prescribed duration, even if symptoms improve quickly. Not taking your doses regularly can increase the chance of developing an infection resistant to treatment. Paromomycin is not able to help treat the symptoms of a viral disease like influenza or the commonly occurring cold.

Maintain room temperature and far from moisture and heat.

Details on dosage

Usual Adult Dose for Amebiasis:

between 25 and 35 mg/kg taken orally in 3 doses at meals for 5 to 10 days.
The drug is ineffective against extraintestinal amebiasis.
Use: To treat intestinal amebiasis (acute and chronic).

Usual Adult Dose for Hepatic Coma:

4 grams per day taken orally in doses divided (at regularly scheduled times) up to 5 days
Use: as an adjunctive therapy to treat liver compa

Usual Adult Dose for Dientamoeba fragilis:

US CDC Recommendations: 25 to 35 mg/kg/day taken orally in 3 doses for 7 days
It is recommended as a treatment for infections caused by Dientamoeba fragilis.
The current guidelines should be reviewed for more details.

Usual Pediatric Dose for Amebiasis:

Between 25 and 35 mg per kg/day, orally in 3 doses, in conjunction with meals for 5 to 10 consecutive days
The drug is ineffective against amebiasis of the extraintestinal lining.
Use: To treat intestinal amebiasis (acute and chronic).

Usual Dose for Children: Dientamoeba fragilis

American Academy of Pediatrics Recommendations 25–35 mg/kg/day, orally in 3 equal doses for 7 days.
It is recommended as a method to treat infections caused by D. fragilis.
The current guidelines should be read for further details.

What happens If I miss a dose?

You should take the medication as quickly as you are able, but do not take your missed dose if it's nearing the time to take the next dose. Don't take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activity.

Interaction with other drugs

Other medications can affect paromomycin, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about the medicines you are currently taking as well as any medications you are about to start or stop taking.



Prescription only

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