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Signifor LAR

The generic name is pasireotide [PAS-i-REE’-oh-tide]. Brand Names: Signifor, Signifor LAR
The class of drugs: somatostatin and somatostatin analogs

What is Signifor LAR?

The LAR protein is a human-made protein that is identical to a hormone that is found in our body, somatostatin.

Signifor LAR can be used to treat Cushing's disease as well as Acromegaly (endocrine diseases). The medication is typically prescribed following operations or any other treatment that has failed, did fail, or ended up failing.

Signifor LAR can also be used to treat conditions that are not covered in this medication guide.

Side effects of Signifor LAR

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such as hives, difficulty breathing, or swelling of your lips, face, or tongue.

Significant LAR can result in severe adverse effects. Consult your physician immediately in the event that you are suffering from:

  • Rapid or slow heartbeats;
  • Suddenly dizzy (like the possibility of passing out);
  • Blood sugar levels are high—increased thirst, more frequent urinary frequency, odor of fruity breath fatigue, losing weight even if more hungry than usual.
  • Ketoacidosis (too much acid in the blood) ketoacidosis (too much acid in the blood) vomiting,  nausea, stomach discomfort, confusion, tiredness, or difficulty breathing;
  • Low levels of cortisol, nausea and vomiting, changes in appetite, headache, disorientation, and slurred speech. Feeling tired, weak, and anxious. Shaking, lightheaded,
  • Problems associated with the gallbladder include chalky-colored stools, stomach pain immediately following eating a meal, heartburn, bloating and upper stomach discomfort that may radiate to your back.

Common adverse effects of Signifor LAR could include:

  • High blood pressure;
  • Abnormal results from blood tests;
  • Being tired or weak;
  • Lack of appetite; nausea, stomach discomfort, or bloating diarrhea;
  • Headache;
  • Swelling rapidly, gaining weight;
  • Lower back pain;
  • Cold symptoms such as a stuffy nose and sneezing
  • Hair loss;
  • Redness, pain, itching, bleeding, or bruises in the area where the medicine was injected

This list is not inclusive and other side effects could arise; for medical advice on possible side effects please contact your physician. Any symptoms should also be reported directly to the FDA at 1-800-FDA-1088.


Significant LAR could reduce your cortisol levels. Tell your doctor when you experience symptoms like nausea or vomiting, changes in appetite, headache, irritability, confusion, slurred speech, or feeling tired, weak, and anxious. Shakey or lightheaded.

Significant LAR may raise blood sugar levels and could result in the development of diabetes. Your blood sugar might require testing prior to and during treatment with Signifor LAR. Contact your physician if you are experiencing increased thirst or urination, fatigue, or weight loss, even if it seems like you're more hungry than normal.

Prior to use this drug

It is not recommended to apply Signifor LAR to your body if you are sensitive to it.

Inform your doctor if you were ever diagnosed with:

  • Diabetes, also known as high blood sugar
  • Liver disease;
  • Heart issues;
  • Gallstones
  • An electrolyte imbalance (such as a low level of magnesium or potassium within your blood)

It isn't known if Signifor LAR can harm the unborn baby. Inform your doctor if you are expecting or planning to be pregnant.

Signifor LAR can alter the hormone levels of premenopausal women and increase the chance of an unintended pregnancy. Consult your doctor regarding your risks.Breastfeeding is not advised when using Signifor the LAR.

How to take Signifor LAR?

The doctor will run blood tests to confirm that you don't have any issues that could make it unsafe for you to use Signifor LAR.

Follow all the instructions on your prescription label, and review all medication guides and instructions sheets. Your doctor may change the dosage. Follow the medication precisely as prescribed.

Signifor LAR can be injected under the skin or into muscles. A doctor can show you how to correctly apply the medication yourself.Signifor LAR is injected into the muscle every 4 weeks. The healthcare professional will offer you this kind of injection. Pasireotide injection.Be sure to read and adhere to any instructions for use that come with your medication. Talk to your pharmacist or doctor to clarify any instructions.

Your doctor will inform the body part to inject the signifor LAR. Make sure to inject at a different location every time you administer an injection. Don't inject the same spot twice in one row. Beware of skin that is irritated or red.

Signifor LAR could increase your blood sugar levels, and you may be diagnosed with diabetes or pre-diabetes. The blood sugar of your patients will need to be measured prior to and during treatment with this medication. You might need to begin with diabetes medication or alter the dosage of the medication you are already taking. Follow the directions of your doctor meticulously.The function of your heart may require checking with an electrocardiograph, or ECG (sometimes abbreviated as EKG).Keep the signifier at room temperature, away from heat, moisture, and light. Discard an ampule after a single use, regardless of the medicine in it.

If you keep Signifor Lar in your home environment, store it in the original container within the fridge. Don't freeze it. Remove the medicine from the refrigerator and allow it to get to room temperature for about 30 minutes prior to injecting the dose. Do not keep the medicine for more than 24 hours.

Make use of a needle and the syringe once only, and put them in a puncture proof "sharps" container. Be sure to follow the laws of your state or city regarding how to dispose of the container. Keep it out of the reach of pets and children.

What happens if I miss the dose?

Take the medication as quickly as you are able, but do not miss any missed doses if you are nearing the time to take the next dose. Don't take two doses in one go.

If you don't take your dosage of Signifor L.A., you will get your missed dose until 14 days prior to the next dose.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Follow the doctor's advice regarding any limitations on foods, drinks, or any activity.

Interaction with other drugs

The significant LAR could cause serious heart issues. Your risk is higher if you take various other medications for asthma, infections, and heart issues. High blood pressure, depression, mental illness, malaria, cancer, or HIV.

Inform your doctor about all the medications you take. Certain drugs may affect Signifor LAR, including:

  • Bromocriptine;
  • Cyclosporine;
  • Heart or blood pressure medications
  • Medications to regulate the levels in your blood of magnesium or potassium.

This is not a complete list, and other drugs could cause a change in the Signifor LAR. This includes prescription and over-the-counter medications, vitamins, and herbal remedies. There are many possible interactions between drugs that are included here.