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Generic name: Lubiprostone [loo-bee-PROS-tone]
Drug class: chloride channel activators

What is Amitiza?

Amitiza enhances the release of bile in the digestive tract, which makes it easier to pass stool (bowel motions).Amitiza helps treat constipation that is chronic or constipation that is caused by opioid (narcotic) pain medications.Amitiza can also be utilised to treat the symptoms of irritable constipation in women suffering from constipation as the primary symptom.Amitiza is only available to adults.


It is not recommended to take Amitiza in the event of an obstruction within your digestive tract or if you suffer from extreme diarrhoea.Take a break from Amitiza and consult your physician when you feel dizzy each time you take this medication or if you suffer from excessive diarrhoea.The baby who is nursing could get diarrhoea if mom takes Amitiza during nursing. Talk to your doctor if you are nursing a baby, and speak to your doctor in the event that your baby experiences diarrhoea.You might feel tension in the chest area or experience shortness of breath in the first hour after taking this medication. The side effect should be gone within 3 hours; however, it could happen again after you take the next dose. Discuss this with your doctor when this condition is uncomfortable.Consult your physician immediately. If you experience persistent or severe sickness or vomiting,

Prior to use this drug

It is not recommended to take Amitiza if you've got an obstruction within your digestive tract or if you suffer from extreme vomiting.Speak to your doctor if you have had any liver problems.Contact your doctor if are pregnant or breastfeeding.If you're nursing, inform your doctor if there is diarrhoea in your baby.Amitiza is not permitted to be used by anyone younger than 18 years of age.

How to take Amitiza?

Amitiza is generally taken two times a day. Follow the instructions on your prescription label, and review all medication guides and instructions sheets.Include food and drink.Take the capsule in its entirety and don't crush, chew, break, or even open it.You might feel chest tightness or experience shortness of breath in the first hour following the use of Amitiza. This effect is expected to be gone within 3 hours, but it might be present again after taking the next dose. Consult your physician in the event that this reaction is uncomfortable.Do not consume Amitiza If you suffer from excessive vomiting, Call your doctor for advice.Your doctor will examine your health frequently.Place it in a cool, dry place away from light and heat.

Details on dosage

Usual Adult Dose for Constipation—Critical:

24 mg orally, 2 times a day
Comments: The efficacy of this drug in treating constipation induced by opioids for patients who take diphenylheptane opioids (e.g., methadone) is not confirmed.
Treatment for constipation that is chronically idiopathic as well as opioid-induced constipation in adults who suffer from chronic pain, which is non-cancer,

Usual Adult Dose for Irritable Bowel Syndrome:

8 mg orally, 2 times a day
Treatment: for constipation and irritable bowel syndrome (IBS-C) in women aged 18 and over.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, do not take your missed dose if it's nearing the time to take the next dose. Don't have two doses at one time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Side effects of Amitiza

Take immediate medical attention in the event that you exhibit symptoms that you are experiencing an allergic reaction (Amitiza): hives, breathing problems, and swelling of your lips, face, and tongue.

Contact your doctor immediately. If you suffer from:

  • Chronic or constant vomiting or diarrhoea
  • Trouble breathing trouble breathing
  • Feeling lightheaded, like you're about to pass out.

It is possible that you are suffering from lower blood pressure and will experience fainting shortly after taking this medication, particularly if you've had a bout of diarrhea. Take amitiza off the market and contact your physician if you're feeling faint after each dose or if you experience excessive diarrhoea.

Common side effects of amitiza include:

  • Nausea, stomach pain;
  • Gas, diarrhoea, bloating,
  • Headache.

This is not a comprehensive list of possible side effects, and other side effects could occur. Talk to your doctor and seek medical advice regarding the consequences.You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Be sure to inform your doctor whether you are taking an opioid pain medication.Other medications can interfere with lubiprostone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about any other medicines you are taking.




Prescription only

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