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Generic Name: [MET-roe-NYE-da-zole]metronidazole vaginal

Brand Names: Nuvessa, Vandazole
Classification of medications: topical anti-rosacea agents, vaginal anti-infectives

What is Vandazole?

Vandazole (for use in vaginas) is an antibiotic that is used to treat vaginal infections caused by bacteria.Don't use metronidazole to treat any illness that hasn't been evaluated by your physician.

Vandazole is also employed for other purposes that are not covered in this guideline for medication.

Side effects of Vandazole

Take immediate medical attention. If you notice symptoms that indicate an allergy (hives or itching, or sensation of warmth or tingling, joint pain, dry fever, dry vagina, stuffy nose, difficulty breathing, swelling of your throat or face) or a severe reaction to your skin (fever and sore throat, eye burning, irritation, and red or purple skin eruption with peeling and blisters),

Some rare but serious adverse effects can include:

  • Seizure (convulsions);
  • Sensation of burning, numbness, or tingling sensations on your feet or hands.

Contact your doctor immediately if you notice any recent or more severe vaginal signs.

Common adverse effects of Vandazole could include:

  • Vaginal discharge or itching
  • Menstrual cramps and heavy bleeding
  • Breast pain;
  • Headache;
  • Rash, itching;
  • Stomach discomfort, nausea, diarrhea, nausea, and stomach pain
  • Symptoms of the cold, like nasal stuffiness, sneezing, and a sore throat.

This isn't a complete list of possible side effects, and other side effects could occur. Contact your doctor for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Metronidazole should not be used in the event that you've taken disulfiram (antabuse) within the last two weeks.

Do not consume alcohol or any food items or medicines containing propylene glycol while using metronidazole, and for a minimum of 3 days following the time you have stopped taking it.

Before you take this drug

You shouldn't make use of Vandazole if you are sensitive to metronidazole, secnidazole, or tinidazole, or if:

  • You are sensitive to polyethylene glycol.
  • You recently had a drink. You recently drank alcohol.
  • You took disulfiram (antabuse) in the last 14 days.

Inform your doctor if you have ever suffered from:

  • Nerve issues
  • A seizure;
  • Peripheral cardiovascular disease like Raynaud's disease.

It is unclear if this medication will affect a newborn baby. Inform your doctor if you are expecting.

It is not recommended to feed your baby within the first 48 hours of the use of metronidazole. If you use an infant pump during this period, dispose of any milk you can collect. Don't give it to your infant.Vandazole is not recommended for use by children under 12 years old or for girls who are not yet in menstrual cycles.

How to take Vandazole?

Follow the instructions on the label of your prescription and read the medication guide or instructions sheets.Make sure that you use your medication exactly as prescribed.Take this medication before bedtime.Vandazole is usually prescribed in a single dosage. It is, however, possible to take the medication for five nights in the same row. Follow the dosing guidelines of your doctor extremely carefully.

Do not take Vandazole by mouth. It's only to be used within the vagina.Be sure to read and adhere to any instructions for use that come with your medication. Consult your physician or pharmacist if you don't understand these directions.Cleanse your vaginal area prior to applying the medication. Cleanse your hands prior to or after using the medication device or tube.Place the medicine straight into the vagina using the applicator supplied. Each applicator that is disposable is designed for only one use.

You might need to utilize a sanitary napkin for treatment, but don't make use of a tampon. Avoid using a douche or any other vaginal product when taking Vandazole.Make sure to take this medication for the entire prescribed duration, even if symptoms do not improve immediately. Inadequate doses could increase the chance of developing an infection that is intolerant of treatment.

Contact your physician if your symptoms don't improve or if they become worse.Do not share this medication with someone else, even if they suffer from similar symptoms to yours.This medicine may affect the outcomes of certain medical tests. Inform any physician who treats patients that you're using Vandazole.

Vandazole is not a treatment for a vaginal yeast infection. You could even get an infection in your vagina and need to be treated with antifungal medications. Inform your doctor if you are experiencing symptoms such as an itch or discharge following treatment with this medication.Place it in a cool, dry place far from heat or moisture. Do not refrigerate or freeze.

What happens if I miss the dose?

Take the medication as quickly as you can; however, do not miss any missed doses if it's nearing time to take the next dose. Don't take two doses at once.

What happens if I overdose?

A dose of Vandazole isn't likely to pose any danger. You should seek medical attention in an emergency or contact the Poison Helpline at 1-800-222-1222 in the event that someone has swallowed the drug accidentally.

What should be avoided?

When you're taking Vandazole for three days following the final dose Beware of drinking or consuming food or other items that contain propylene glycol. Drinking alcohol can have unpleasant side effects, such as headaches, nausea, and stomach cramps, as well as the sensation of warmth or tingling on your skin.

Do not wear tight-fitting, synthetic clothes like pantyhose and nylon underwear that do not allow air circulation. Wear loose-fitting clothing that is made of cotton or various other fibers that are natural until the inflammation is gone.Injecting this medication into your eyes may cause irritation or burning. If contact does occur, wash your eyes with water and then call your doctor.Do not use other vaginal medicines unless your doctor advises you to. Don't have sexual contact until your vaginal infection is completely taken care of.

Interaction with other drug

Discuss with your doctor all other medicines you take, particularly:

  • Lithium
  • A blood thinner (Warfarin, Coumadin, Jantoven)

This list isn't complete. Other medications may interact with Vandazole, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs, which are included here.