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Estradiol and Progesterone

Generic name: estradiol and progesterone [ES-tra-DYE-ol-and-pro-JES-ter-one]

Brand name: Bikuva
Dosage form: oral capsule (1 mg–100 mg)
Drug classes: Combinations of sex hormones

What is Estradiol and Progesterone?

Estradiol is a female hormone called progesterone.Combination medicine consisting of estradiol (progesterone) and estrogen is used to treat hot flashes that are moderate to severe and caused by the menopause.Estradiol and progesterone are only for women who have not removed their uterus.This medication guide does not list all possible uses for estradiol or progesterone.

Side effects of Estradiol and Progesterone

If you experience any of the following symptoms of an allergy: difficulty breathing, hives, swelling in your lips, face, throat, or tongue

Progesterone and estradiol can cause severe side effects. If you experience:

  • Heart attack symptoms: chest pain, pressure or pain in your shoulder or jaw, nausea, and sweating.
  • Signs of stroke: sudden numbness (especially on one side), severe headache; slurred or shaky speech.
  • Signs of blood clots: sudden vision loss, shortness of breath, blood in the cough, or pain or heat in both or one leg;
  • Rapid weight gain and swelling
  • Jaundice
  • Unusual vaginal bleeding and pelvic pain
  • A lump on your breast,
  • High levels of calcium are accompanied by nausea, vomiting, and constipation. Other symptoms include muscle weakness, pain in the bones, fatigue, or increased thirst.

Some of the common side effects associated with estradiol or progesterone include:

  • Pelvic pain
  • Vaginal bleeding or discharge;
  • Breast tenderness

There may be other side effects. For medical advice on side effects, call your doctor.Call the FDA's Injury Hotline at 1-800-FDA-1088 if experiencing side effects.


Estradiol or progesterone should be avoided if the uterus was removed, you suffer from undiagnosed bleeding, have a bleeding disorder, or have had major surgery. You also shouldn't use it if you are planning a major operation or have had heart attacks, strokes, blood clots, cancer of the breast, uterus, cervix, or vagina.Estradiol can increase the risk that you develop a condition that may eventually lead to cancer of the uterus. If you experience any bleeding, call your doctor.This medicine may increase the risk of stroke, blood clots, or breast cancer. Progesterone and estradiol should not be taken to treat heart disease or stroke.

Before you take this drug

If your uterus was removed or you

  • Unusual vaginal bleeding not checked by your doctor
  • Liver disease
  • An increased risk for blood clots as a result of a blood disorder or heart disease;
  • An individual with a history of stroke, heart attack or blood clot should seek medical advice immediately if symptoms arise, including symptoms like dizziness, headache and/or abdominal discomfort.
  • A history of cancers of the breast, cervix, or uterus

If you've ever:

  • Heart disease High blood pressure
  • Gallbladder Disease
  • If you are pregnant or using hormones, it can cause liver damage or jaundice.
  • Kidney disease
  • Diabetes;
  • Asthma;
  • Epilepsy
  • Migraines;
  • Lupus;
  • Endometriosis or uterine fibroid tumors;
  • Hereditary Angioedema
  • A thyroid disease;
  • High levels of calcium are found in the blood.

This medicine should not be taken to prevent strokes, heart attacks, or dementia. The medicine can actually increase the risk that you will develop these diseases.

Estrogens may increase the risk of stroke or heart attack. If you suffer from high blood pressure or diabetes, high cholesterol, or are overweight, you may be at greater risk.You may be at greater risk for cancers of the uterus or ovaries if you are taking estrogens. Speak to your doctor regarding this possibility.Progesterone and estradiol should not be used by women who are pregnant or breastfeeding.

How to take Estradiol and Progesterone?

Read all the instructions or guides that come with your medication and follow all the directions. Follow the directions on your prescription label.Take along your food.You may have to temporarily stop taking estradiol or progesterone if you are going through major surgery, long-term restraints, etc. You should let any doctor who treats you know that estradiol or progesterone is being used.If you experience unusual bleeding in the vaginal area, call your doctor.You should have your doctor check on you regularly (every three to six months) in order to decide whether or not to continue the treatment. You should self-examine for lumps in your breasts every month and get a mammogram once a year when using estradiol or progesterone.Keep away from heat and moisture. Keep it at room temperature.

Details on dosage

Adult dosage for postmenopausal symptoms:

Take 1 capsule of estradiol (1 mg) and progesterone (100 mg) once daily in the evening, with food.
The duration of hormone replacement therapy must be kept as short as possible, taking into account the treatment goals for each woman and the risks involved.
Reevaluate regularly to see if the treatment remains necessary.
Menopausal symptoms of mild to moderate severity can be treated with this medication.

What happens if I miss the dose?

If you are due to take your next dose in less than two hours, skip the missed one. Take only one dose at a time. Do not take multiple dosages simultaneously.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Smoking is harmful. While using estradiol or progesterone, your chances of getting a blood clot, a stroke, and/or undergoing a heart attack are greatly increased.This medicine may cause unwanted side effects if grapefruit is taken with it. Use grapefruit-free products.

Interaction with other drug

It is sometimes not safe to take certain drugs at the same time. Some medications can cause side effects that increase or decrease the effectiveness of another drug you are taking.Estradiol can cause interactions with many drugs. These include prescription drugs, over-the-counter medications, vitamins, and herbal products. This medication guide does not list all interactions. Inform your doctor of all the medications you are currently taking and those that you will stop or start using.