Signifor

What is Signifor?

Signifor is a synthetic protein that is like a hormone found within the body known as somatostatin. Pasireotide reduces the amount of hormones made by the body.It is used in the treatment of Cushing's syndrome or acromegaly (endocrine conditions).

Signifor is usually prescribed following surgery or after other treatment options have been tried but without results.

Warnings

Signifor could lower the levels of cortisol in your body. Consult your physician if you notice any symptoms, such as vomiting, nausea, vomiting, changes in appetite, headache, disorientation, or slurred speech. You may also be feeling tired, weak, and anxious. Shakey, or lightheaded.

Signifor may raise the level of your blood sugar, which can result in diabetes. Your blood sugar levels may require testing prior to and during treatment with this medication. Consult your physician if you are experiencing increased thirst, urination, or fatigue and the loss of weight, even if you feel more hungry than normal.

Prior to use this drug

It is not recommended to use Signifor if your body is allergic to pasireotide.

To be sure Signifor is suitable for you, inform your physician if you suffer from:

• Diabetes, also known as high blood sugar levels,
• Liver disease;
• Heart-related problems;
• Gallstones
• The imbalance of electrolytes (such as a low level of magnesium, potassium, or magnesium in the blood).

It is unclear if pasireotide is harmful to the unborn child. Inform your doctor if you are expecting or planning on becoming pregnant.

Pasireotide can alter the levels of hormones in women who are pregnant and increase the chance of having a pregnancy that is not planned. Consult your doctor regarding your risks.Breastfeeding is not advised when using Signifor.

Similar/related drugs

Dexamethasone, Decadron, Cyproheptadine, and Mifepristone

How to take Signifor?

Make sure you use Signifor according to the prescriptions given by your physician. Follow all instructions on the prescription label and study all the medication instructions or sheets. The doctor might alter your dosage.

The doctor will conduct blood tests to confirm that you don't have any medical conditions that hinder you from using pasireotide.Signifor is injected underneath the skin, generally every day, twice. Healthcare professionals can show you how to correctly apply the medication yourself.The signiforlar is injectable into muscles once every four weeks. Your healthcare professional will offer you this kind of long-acting injection.

Take note of and follow the instructions for use that are included along with your medicine. Do not take this medicine when you don't know the entire procedure for use. Consult your physician or pharmacist in case you're not understanding all directions.Your healthcare provider will tell you the best place to inject Signifor. You should use a different spot every time you administer an injection. Avoid injecting into the same area twice in one row. Beware of skin that is irritated or red.

Signifor may increase blood sugar levels, and you could develop diabetic or prediabetic symptoms. Your blood sugar is required to be measured before and during treatments with pasireotide. It is possible that you will need to begin with diabetes medication or alter the dosage of medications you're already taking. Follow your doctor's advice attentively.

The heart's function could need to be monitored with an electrocardiograph, or ECG (sometimes known as the EKG).Keep it in a cool, dry place, away from heat, moisture, and light. Toss the ampule out after a single use, even if there's some medicine remaining within.

If you keep Signifor the LAR inside your house, make sure to keep your original container and store it in the refrigerator. Don't freeze. Remove the medicine from the refrigerator and allow it to reach room temperature for about 30 minutes before injecting the dose. Don't leave the medicine for more than 24 hours.

Make use of a needle and the syringe once only, and place them into the puncture proof "sharps" container. Make sure you follow local or state laws regarding how to dispose of the container. Make sure it is out of reach of pets and children.

Details on dosage

Usual Adult Dose for Cushing's Syndrome:

Intramuscular formulation:
Initial dose: 10 mg intramuscularly once every four months (28 days).
Maximum dosage: 40 mg intramuscularly, every four weeks (28 days) after the 4-month period of therapy. 10 mg for those who have not normalized 24-hour urinary cortisol (UFC) levels following 4 months of treatment and who were able to tolerate the dose of 10 mg.
Subcutaneous formulation:
Initial dosage: 0.6 mg or 0.9 mg subcutaneously, twice daily.
Dosage for maintenance: 0.3 to 0.9 mg subcutaneously, twice daily.
Maximum dosage: 0.9 mg subcutaneously twice each day.
The duration of therapy should continue until the benefit has been gained.
Comments:
Tirate dose is based on response and tolerance.
Conduct baseline tests of the hemoglobin A1c electrocardiogram and liver tests of serum potassium and magnesium levels in the serum prior to beginning treatment.
Optimize the control of glucose for diabetics with poor control prior to initiating treatment.
Treatment: The treatment for adult patients suffering from Cushing's disease who have pituitary surgery that cannot be considered or hasn't been curative

Usual Adult Dose for Acromegaly:

Intramuscular formulation:
Initial dose: 40 mg, IM, every 28 days
Maximum dosage: 60 mg IM at least every 28 days for those without normal growth hormone (GH) or age- or gender-adjusted IGF-1 (IGF-1) levels after three months of treatment who could tolerate the dose of 40 mg.
Comments:
Dosage is based on reaction and tolerance.
Examine fasting plasma glucose hba1c levels, liver enzymes, electrocardiogram, as well as potassium and magnesium levels in the serum prior to treatment.
Improve glucose control in patients with poor control of diabetes prior to starting therapy.
Use: Treatment for patients suffering from acromegaly and having an insufficient response to surgery or for whom surgery isn't an alternative.

What happens if I miss the dose?

Utilize the medication as soon as you are able, but do not miss your missed dosage if you are nearing the time to take the next dose. Don't take two doses at once.

If you do not take a dosage of the drug, Signifor LAR, it is possible to receive your missed dose for up to 14 days prior to your next dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Helpline at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any limitations on foods, drinks, or any activity.

Side effects of Signifor

Seek medical attention immediately. If you are experiencing symptoms of an allergic reaction, symptoms such as hives, difficulty breathing, or swelling of your lips, face, and tongue.

Contact your doctor immediately. If you suffer from:

• Heartbeats that are slow or fast
• Unexpected fainting (like the possibility of passing out);
• Blood sugar levels are high, which is a sign of increased thirst, more frequent urination, the smell of fruity breath, fatigue, and weight loss when you're more hungry than normal.
• Ketoacidosis (too excessive acidity in the blood): nausea, stomach pain, vomiting disorientation, unusual drowsiness, or difficulty breathing;
• Low levels of cortisol, nausea or vomiting, changes in appetite, headache, irritability, confused speech, or confusion or feeling tired, weak, nervous, unstable, or lightheaded
• Gallbladder-related problems include colored stools that are chalky, stomach pain after eating, and heartburn, bloating, and stomach pain in the upper part of your stomach, which may then extend onto your back.

Common signs and symptoms include:

• High blood pressure
• Abnormal results from blood tests;
• Being tired or weak;
• Lack of appetite and nausea; stomach discomfort or bloating diarrhea;
• Headache;
• Swelling and rapid weight gain
• Back discomfort;
• Signs of a cold, like congestion of the nose and sneezing;
• Hair loss;
• Itching, pain, redness, bleeding, or bruising at the site of the injection

This isn't a complete list of possible side effects, and others could happen. Consult your physician for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Signifor may cause a serious heart issue. Your risk of developing heart problems is more pronounced if you use various other medications for asthma, infections, heart conditions, high blood pressure, depression, mental illness, malaria, cancer, or HIV.

Inform your doctor about all the medications you are taking. A variety of drugs can be incompatible with Signifor, including:

• Bromocriptine;
• Cyclosporine;
• Blood pressure or heart medication and
• Medications to regulate the levels in your blood of magnesium or potassium.

This is not a complete list, and other medications may interfere with Signifor. This includes prescription and over-the-counter medications, vitamins, and herbal products. There are many possible interactions between drugs, which are included here.