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Sirolimus topical

Brand name: Hypertor
Dosage form: topical gel (0.2%)
Drug classes: MTOR inhibitors, selective immunosuppressants

What is the Sirolimus topical?

Sirolimus is used topically to treat people aged 6 and older who have a tumour on their face called angiofibroma, caused by the genetic disorder tuberous sclerosis. Sirolimus topical can be used in other ways not mentioned in this guide.

Side effects of Sirolimus topical

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of the face, lips, or throat.

Sirolimus can cause a brain infection, which may lead to death or disability. If you experience problems with your speech, thinking, vision, or muscle movements, tell your doctor. These symptoms may get worse very quickly.

Sirolimus can cause serious side effects. If you experience:

  • Signs of infection: fever, chills, sore neck; body aches; unusual fatigue; loss of appetite or appetite; bruising, bleeding, or bruising.
  • Chest pain, shortness of breath, or a new or worsening cough.

Side effects of sirolimus topical include:

  • Acne, rash, skin bleeding, dry skin;
  • Itching at the treatment site
  • Itching
  • Eye redness.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


Do not use it other than as directed. Inform your doctor of any other medications you are taking or if you have allergies or other medical conditions.

Before you take this drug

If you have an allergy to sirolimus, then it is best not to use the topical.

Inform your doctor of any of the following issues:

  • Skin infection on the treatment site
  • High blood cholesterol or high levels of triglycerides (fats or lipids)
  • If you have a scheduled vaccination,

Can harm an unborn child. A pregnancy test may be necessary to confirm that you are not pregnant. Use birth control for at least 12 weeks after the last dose and while you are using sirolimus. Inform your doctor immediately if you fall pregnant.

Sirolimus topical can affect the fertility of men and women. Sirolimus topical can make it harder for either parent to get pregnant.

How to take Sirolimus topical?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label. Use soap and water to wash your hands after applying sirolimus topical. Apply topical sirolimus to the face at least twice daily, morning and night. Covering treated skin with bandages is not recommended unless you are told to by your doctor.

If the skin doesn't improve after 12 weeks, call your doctor. The use of sirolimus topically may increase the risk of cancer. Consult your doctor to determine your personal risk. During treatment, your blood may be tested. Do not freeze. Store in the fridge.

Details on dosage

Adult dose for angiofibroma:

Use the usual dose twice daily, in the morning and before bed.
Maximum dose: 800 mg (2.5 cm)
Reassess whether you need to continue this medication if symptoms don't improve after 12 weeks of treatment.
Use: Topical treatment for facial angiofibroma in tuberous sclerosis

The usual paediatric dose for angiofibroma is:

Use the usual dose by applying it to the affected skin twice daily, in the morning and before bed.
Patients aged 6 to 11 can receive a maximum dose of 600 mg (2 cm), while patients aged 12 to 18 are allowed a maximum of 800 mg (2.5cm).
Reassess whether you need to continue this medication if symptoms don't improve after 12 weeks of treatment.
Use: Topical treatment for facial angiofibroma in tuberous sclerosis

What happens if I miss the dose?

If it is almost time for your next dose, skip any missed dosage. Never apply two doses at once.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Sirolimus topical can cause you to burn more quickly. Avoid tanning beds or sunlight. When you're outdoors, wear protective clothing and use sunblock (SPF 30 or higher).

Avoid receiving "live" vaccinations. You may find that the vaccine does not work well when you use sirolimus. Live vaccines are measles (MMR), rubella, typhoid (yellow fever), rotavirus (typhoid), varicella, typhoid (typhoid), yellow fever (yellow fever), zoster, varicella, and chickenpox (shingles). Avoid getting sirolimus in your mouth, eyes, or vagina.

Interaction with other drug

It is sometimes not safe to take certain medications at the same time. Some drugs may affect the blood levels of drugs that you are taking, causing side effects or making them less effective. Sirolimus topical may be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Notify your doctor of all medications you are currently taking.