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Generic Name: Hydrochlorothiazide and bisoprolol [HYE-droe-klor-oh-THYE-a-zide-and-bi-SOE-proe-lol]
The class of Drug: Beta blockers with thiazides

What is Ziac?

Ziac includes a mix consisting of hydrochlorothiazide and bisoprolol. Hydrochlorothiazide can be described as a diuretic that consists of a water tablet. Bisoprolol is a beta-blocker.Ziac is a treatment for the problem of high blood pressure (hypertension).

Ziac tablets can be purchased in three strengths: 2.5 mg/6.25 mg (bisoprolol fumarate 2.5 mg and hydrochlorothiazide 6.25 mg), five mg/6.25 mg (bisoprolol fumarate 5 mg and hydrochlorothiazide 6.25 mg), and 10 mg/6.25 mg (bisoprolol fumarate 10 mg and hydrochlorothiazide 6.25 mg).


It is not recommended to take Ziac in the event that you are unable to urinate. It is not recommended to make use of Ziac when you suffer from an extremely serious heart problem like "sick sinus syndrome" or "AV block," severe heart failure, or a slow heartbeat that results in you falling.

Before taking Ziac, consult your physician whether you suffer from congestive heart issues, circulatory problems, liver or kidney problems, glaucoma, or cirrhosis. asthma, bronchospastic pulmonary disease, thyroid disorders such as gout, lupus, lupus diabetes, or a penicillin allergy.

If you're suffering from diabetes, be sure to check your blood sugar levels carefully. Bisoprolol may make it more difficult to determine if you suffer from lower blood sugar levels. The insulin or diabetes medication you require could change while you're taking Ziac. Discuss this with your doctor prior to making any changes to your dose.

Beware of becoming dehydrated or overheated during workouts and in hot temperatures. Follow the instructions of your physician regarding the types and amounts of fluids you need to consume. In certain instances, drinking too much fluid can be just as harmful as not drinking enough.Continue to take Ziac even when you feel well. High blood pressure can have no signs.

Before you take this drug

Ziac should not be used. Ziac in the event that you are allergic to bisoprolol or hydrochlorothiazide or if you suffer from:

  • Uncontrolled or severe heart failure;
  • Irregular heartbeats, which have caused the patient to fall unconscious;
  • A serious heart condition known as "sick sinus syndrome" or "AV block" (2nd or 3rd degree);
  • An allergy to sulfa medications
  • If you're not able to eliminate

To ensure that Ziac is appropriate for you, ask your doctor if you are suffering from:

  • Congestive heart failure;
  • Asthma or another breathing disorder;
  • Diabetes;
  • A thyroid disorder
  • Glaucoma;
  • Peripheral vascular diseases, such as Raynaud's disease;
  • Kidney disease;
  • The liver (or cirrhosis);
  • Lupus;
  • Gout
  • An allergy to sulfa-containing drugs or penicillin.

It isn't known if Ziac can cause harm to a baby who is not yet born. Consult your physician if you are expecting or planning to become pregnant.

It is not advised to give birth during the time you take this medication.

Ziac is not a product that has been approved to be used by anyone younger than 18 years old.

How to take Ziac?

Use Ziac exactly as directed by your physician. Follow the directions on the label of your prescription and make sure you read the entire medication guide or instruction sheet. The doctor might modify your dosage.

Consult your doctor if you are suffering from diarrhea or are sweating more than normal. It is easy to get dehydrated when you take Ziac. This could result in lower blood pressure, a severe electrolyte imbalance, or kidney failure.Your blood pressure needs to be regularly checked. The urine and blood could be tested in the event that you've been vomiting or dehydrated.

If you're diabetic, you should check your blood sugar levels carefully. The use of bisoprolol can make it difficult to determine if you suffer from insufficient glucose levels. The amount of blood sugar and diabetes medication requirements could change when you're taking Ziac. Don't change your dose or schedule without consulting your physician.

If you require medical or surgical procedures, be sure to inform the doctor that you're currently taking this medicine. It is possible to stop taking the medicine for a brief period of time.Do not miss doses or stop taking Ziac suddenly. Stopping suddenly may cause your condition to get worse. Follow your doctor's advice on tapering your dose.

Continue to take this medicine according to the directions, even if you are not feeling well. High blood pressure can have no signs. It could be necessary to take medication for high blood pressure throughout your life.Keep the bottle. the bottle at room temperature, far from moisture and heat. Make sure the bottle is tightly sealed when not being used.

Details on dosage

Usual Adult Dose of Ziac for Hypertension:

Initial dose: bisoprolol 2.5 mg and hydrochlorothiazide 6.25 mg orally once a day.
Maximum dose: bisoprolol (20 mg) and hydrochlorothiazide (12.5 mg) orally once a day.
Increase the dose every 14 days if you are not able to achieve the optimal response.
It is possible to substitute this drug to titrate individual components (e.g., an insufficient control of bisoprolol 2.5 to 20 mg or an adequate control of hydrochlorothiazide, 50 mg, however, with a significant loss of potassium).
Avoid abrupt discontinuation and taper the treatment gradually over about 2 weeks.
If withdrawal symptoms develop, therapy can be temporarily restarted.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, do not take your missed dose if it's nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.The symptoms of an overdose can include leg cramps, confusion, tingling, and numbness. weak heartbeats or fainting.

What happens if I overdose?

Do not drink alcohol. It could increase blood levels of bisoprolol.Be careful not to get up too quickly from a lying or sitting posture, as you might be shaky. Start slowly and steady yourself to prevent falling.

Hydrochlorothiazide can increase the chance of developing skin cancer. Avoid sun exposure or tanning beds. Be sure to wear protective clothes and apply sunscreen (SPF 30 or greater) while you're outdoors. Your physician may ask you to undergo skin exams regularly.

Side effects of Ziac

See a doctor immediately in the event that you experience symptoms warning of an allergy reaction (hives, breathing difficulties, and swelling of your throat or face) or an intense skin reaction (fever, sore throat, burnt eyes, irritation, and the skin is red or purple with peeling and blisters).

See your doctor right away. If you are suffering from:

  • Chest pain;
  • Rapid, slow, or irregular heartbeats.
  • A feeling of lightheadedness, as if you're passing out;
  • Blurred vision blurred vision, pain in the eyes, or seeing halos around light sources;
  • Breathing shortness (even when exerting only a little), swelling rapidly, and gaining weight;
  • Liver issues the symptoms include nausea, stomach pains in the upper part of the stomach, and itching. Itching can cause fatigue. Nausea, vomiting, black stools, dark urine, jaundice (yellowing of the eyes or skin),
  • Indications for an imbalance of electrolytes such as increased thirst or urination, constipation and muscle pain, weakness, leg cramps, tingling or numbness, experiencing jitteriness, irregular heartbeats, feeling fluttering around your chest, or a choke feeling
  • Blood sugar levels are low, causing headaches, hungry sweating, irritability, anxiety, a fast heart rate, and feeling anxious or shakey.

Common ziac side effects can be:

  • Dizziness;
  • Being tired or weak;
  • Diarrhea, nausea, and indigestion;
  • Headaches migraine

This is not an exhaustive overview of the various negative side consequences. Others could happen. Contact your doctor for advice regarding medical adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Inform your doctor about your other medications, particularly:

  • Colestipol or cholestyramine;
  • Insulin or oral diabetes medicine;
  • Lithium;
  • Sedatives and narcotics;
  • Heart or blood pressure medication such as digoxin, clonidine, diazem, disopyramide, verapamil, clonidine, and more;
  • These are nsaids (nonsteroidal anti-inflammatory medications): aspirin, ibuprofen (advil, motrin), naproxen (aleve), celecoxib, diclofenac, indomethacin, meloxicam, and many others;
  • Steroids: The medicine includes prednisone and many others.

This list isn't complete. Other drugs can be incompatible with bisoprolol and hydrochlorothiazide, such as prescription and over-the-counter drugs, vitamins, and herbal products. Some interactions with drugs are not listed here. are listed here.



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