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Vitrase (injection)

Brand names: Amphadase, Hylenex, and Vitrase

What is Hyaluronidase?

Hyaluronidase is a genetically engineered protein.Injecting fluids into the body along with hyaluronidase can treat dehydration. Hyaluronidase is also used to help your body absorb other injected medicines.

Hyaluronidase can also be used to make contrast dyes more visible on certain types of x-rays and scans.This medication guide does not list all uses of hyaluronidase.

Side effects of Hyaluronidase

Symptoms of an allergic reaction may include hives, difficulty breathing and/or swelling of lips, face, tongue or throat. Seek medical help immediately if this happens to you.

Vitrase may cause serious side effects. If you experience:

  • You may experience swelling of your hands, feet, or other parts of the body.
  • Pain, swelling, itching or redness at the site of injection are symptoms associated with any medication administered intramuscularly.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Warnings

When certain drugs are combined with hyaluronidase, serious drug interactions may occur. Inform your doctor of all medications you are currently taking.

Similar/related drugs

Hyaluronidase, Hylenex, Amphadase, and Dexrazoxane

Before you take this drug

If you have an allergy to hyaluronidase, it should be avoided.Before you take the medication, your doctor may conduct a skin test to determine if you're allergic to hyaluronidase.

Certain medicines can have unwanted or harmful effects when combined with hyaluronidase. If you use:

  • Furosemide (Lasix);
  • Dilantin (phenytoin)
  • A sedative (such as Valium, Xanax, or Ativan) or an anxiety medicine
  • Salicylates or aspirin?
  • Cortisone or ACTH (corticotropin);
  • Oestrogens;
  • Antihistamines (such as cold and allergy medicines) are antihistamines.

Inform your doctor about pregnancy.Breastfeeding may not be possible while taking this medication. You should consult your doctor if you are concerned about any risks.

How to take Hyaluronidase?

Injecting hyaluronidase under the skin or into a muscular tissue, as well as into other body tissues, is the most common way to treat hyaluronidase.

Healthcare providers will administer this injection.Hyaluronidase shouldn't be injected intravenously (into a vein).

What happens if I miss the dose?

You are unlikely to miss a dosage because you will be receiving hyaluronidase in a clinical environment.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Interaction with other drug

Other drugs, such as vitamins and herbal remedies, may also affect hyaluronidase. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using.