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Name of the Generic: Isocarboxazid (e.g. e(e.g.,-karb-BOX-a-zid) [ eye-so-kar-BOX-a-zid.
Drug Class: Monoamine oxidase inhibitors.

What is Marplan?

Marplan is a monoamine-oxidase inhibitor (MAOI), which helps by increasing levels of certain chemical substances in the brain. Marplan is a medication used to treat the symptoms associated with depression, which may include anxiety, panic, or fears. The medication is typically prescribed after various antidepressants have been tried but without success in treating symptoms. Marplan could also be used for other purposes that are not mentioned in this guide.

Side effects of Marplan

See a doctor immediately. If you experience any of the following symptoms, they are warning signs of an allergic reaction: symptoms of hives: breathing difficulties or swelling of your lips, face, and throat. If you notice any new or worsening symptoms, tell your physician, for example, changes in your behavior or mood such as anxieties, panic attacks, or trouble sleeping. You should also tell your doctor when you are feeling uncontrollably angry, irritable, or aggressive. Anxious, hyperactive (mentally and physically), more sad, or contemplating suicide or self-harm. Take a break from Marplan and consult your physician immediately if you are suffering from:

  • The sudden and severe headache that is sudden and severe, rapid heartbeat, stiffness in the neck, vomiting, vomiting, cold sweat eye problems, sensitization to light.
  • Chest pain, a rapid and high heart rate.
  • Swelling and rapid weight gain.
  • Jaundice (yellowing of the eyes or skin).
  • Feeling dizzy, as if you're ready to pass out.

Common adverse effects of Marplan could include:

  • Headache, dizziness, or drowsiness.
  • Tremors.
  • Sleep problems (insomnia).
  • Constipation, nausea.
  • Dry mouth.

This isn't a complete list of all the side effects. Others could happen. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar/related drugs

Rexulti, Trintellix, Sertraline, Trazadone, Lexapro, Citalopram, and Zoloft


There are other medications that can lead to grave medical issues or even death if used in conjunction with Marplan. Before taking this medication, talk to your doctor about any other medications you've used in the last five weeks. Do not take Marplan if you've used another MAO inhibitor within the last 14 days. A risky drug interaction may occur. MAO inhibitors are linezolid, Methylene Blue injection, phenelzine, rasagiline, procarbazine, and tranylcypromine, among others. Many young people are concerned about suicide after using an antidepressant. Your doctor will examine your progress regularly at appointments while you are taking Marplan. Your family members and other caregivers should be attentive to any changes in your attitude or other symptoms.

If you notice any new or more severe symptoms, tell your physician and/or doctor, for example, a change in your mood or behavior such as anxiety, panic attacks, or trouble sleeping. Also, when you are feeling uncontrollably angry, irritable, aggressive, anxious, hyperactive (mentally as well as physically), or more depressed, or when you are thinking about suicide or harming yourself, When you're taking Marplan You should avoid drinking alcohol or eating food items that contain tyramine. This is as listed within this leaflet "What should I avoid while taking this medicine?" part of the leaflet. Consuming tyramine when you take this medication could raise your blood pressure to dangerous levels.

Before you take this drug

Marplan is not a good idea to take if you are allergic to the product or suffer from any of the following:

  • Pheochromocytoma (a tumor that affects the adrenal gland).
  • The liver condition.
  • Kidney disease.
  • An antecedent background that suggests stroke or blood clots.
  • The heart, high blood pressure.
  • An underlying history of chronic or frequent headaches that are frequent or severe.

There are many more medications that could cause grave medical issues or even death if you use them in conjunction with Marplan.

Before you take Marplan, inform your doctor about all medications you've taken in the last 5 weeks. The following medications should not be taken while taking this medication:

  • Buspirone (Buspar).
  • Carbamazepine.
  • Levodopa.
  • Methyldopa.
  • Tryptophan.
  • Certain antidepressants—amitriptylline, bupropion, citalopram, clomipramine, desipramine, doxepin, escitalopram, fluoxetine, fluvoxamine, imipramine, maprotiline, nortriptyline, paroxetine, protriptyline, sertraline, and trimipramine (known by brand names such as Celexa, Lexapro, Luvox, Norpramin, Prozac, Paxil, Wellbutrin, and Zoloft).
  • Narcotic pain medicine: morphine, tramadol, demerol, OxyContin, Percocet, Vicodin, and many more.
  • ADHD treatment options include Adderall, Concerta, Ritalin, Vyvanse, and many more.
  • diet pills.
  • Over-the-counter cough medicine as well as cold medication.

Do not take Marplan. If you've used another MAO inhibitor within the last 14 days. A potentially hazardous medication interaction might occur. MAO inhibitors are linezolid, Methylene Blue injection, phenelzine, rasagiline, procarbazine, and tranylcypromine, among others. To be sure Marplan is suitable for you, inform your physician if you suffer from:

  • A previous history of heart disease (or hypertension).
  • Diabetes.
  • A thyroid disorder.
  • Schizophrenia.
  • Epilepsy or any other seizures.
  • If you've taken any other antidepressant in the last 5 weeks.

A few young people may have thoughts about suicide after using an antidepressant. Your doctor should examine your progress regularly at regular appointments while you are taking Marplan. Family members or other caregivers should be on the lookout for any changes to your mood or signs. FDA pregnancy category C. It isn't known whether Marplan could cause harm to a baby who is not yet born. Consult your physician if you are expecting or planning to become pregnant while taking Marplan. It is unclear if isocarboxazid is absorbed into breast milk or whether it is harmful to nursing infants. Inform your doctor if you are nursing your baby. Don't provide Marplan to anyone who is younger than 16 years of age without the guidance of a physician.

How to take Marplan?

Follow the instructions on the prescription label. Your doctor may adjust the dosage to ensure you get the optimum results. Don't take this medication in greater or lesser doses or for a longer period than the recommended time. Your blood pressure needs to be checked frequently. It is also possible that you will require frequent blood tests to assess your liver's health.

It could take as long as six weeks before symptoms begin to improve. Continue to take the medication according to the directions, and inform your physician if your symptoms don't improve. If you require surgery, inform the surgeon beforehand that you're using Marplan. It is possible that you will have to stop taking the medication for at least 10 days prior to surgery. Place it in a cool, dry place far from heat and moisture.

What happens if i miss a dose?

You should take the missing dosage as soon as you recollect it. If the next dosage is approaching, avoid missing any doses. Do not take extra medication to make up for a missing dosage.

What happens if I overdose?

Get medical attention immediately, contact a doctor for medical attention immediately, or call the Poison Help line at 1-800-222-1222. The signs of an overdose could include shallow breathing, a fast heart rate, sweating, fever, weak reflexes, feeling lightheaded, fainting, or seizures (convulsions).

What should be avoided?

Beware of tea, coffee, cola, energy drinks, or any other beverages that contain caffeine. When you take Marplan, you are not allowed to consume alcohol or eat foods that are high in tyramine, such as:

  • Cheese (especially aged or strong cheeses (especially strong or aged).
  • Yogurt and sour cream.
  • Beer (including non-alcoholic beers) sherry, Chianti alcohol, wine.
  • Dried sausage (such as pepperoni or hard salami), anchovies, caviar, herring, liver.
  • Canned raisins, figs, bananas, figs.
  • Chocolate.
  • Avocados.
  • Soy sauce.
  • Fava beans.
  • Extracts of yeast.
  • Meat extracts.
  • Meat cooked with tenderizer.

It is important to become aware of the list of foods and medications to avoid when you take Marplan. Tyramine consumption while taking this medication can increase blood pressure to dangerous levels, which could lead to dangerous side effects. Marplan can affect your reaction or thinking. Be cautious when driving or engaging in activities that require you to be aware. Be careful not to get up too quickly from a seated or lying position, as you could get dizzy. Make sure to get up slowly and steadily to avoid falling.

Interaction with other drugs

When you take Marplan together with other medicines that cause you to sleep, it can make it more difficult to sleep. Consult your physician before taking Marplan together with a sleeping medication, narcotic pain medication, muscle relaxer, or medication to treat depression, anxiety, or seizures. Numerous drugs may interact with Marplan. Some medicines should not be taken together. This includes prescription and non-prescription drugs, vitamins, and herbal products. There are not all the interactions mentioned in this medication guide. Discuss with your doctor the medicines you are taking or start or stop using in the course of treatment for this medication. Provide a complete list of your medications to any healthcare professional who cares for you.